Survival and predictors of mortality among acute leukemia patients on follow-up in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: A 5-year retrospective cohort study.

BACKGROUND: Although Ethiopia has more than 78% of leukemia cases and a significant burden of the disease, the survival of leukemia patients in the country is poorly recognized. The purpose of this study was to assess the survival and predictors of acute leukemia patients. METHODS: A 5-year retrospective cohort study was conducted including all acute Leukemia patients who visited Tikur Anbessa Specialized Hospital between January 2015 and December 2019. Data were retrieved from patient's medical records between March and April 2020. Using SPSS version 25, the Kaplan-Meier curve and Cox regression models were employed to analyze the data. RESULTS: A total of 119 patients with acute leukemia were retrospectively evaluated for 60 months, having 196 person-years of risk. About 46 deaths (38.7%) were recorded over the follow-up period, giving a mortality incidence rate of 23.5 (95% CL:18-52) per 100 person-years. The median survival time was 35 months (95% CI, 28.3-41.7). At 60 months of follow-up, the predicted overall survival rate after diagnosis for acute leukemia was 21%. The adjusted hazard ratio for acute leukemia subtypes (aHR:4.9, 95% CI:2.3-10.4), history of relapse (aHR:3.9, 95% CI:1.0-7.9), participant age (aHR:1.25, 95% CI:1-1.75), hepatomegaly (aHR:2.7, 95% CI:1.36-5.36), and splenomegaly (aHR:2.29, 95% CI:1.2-4.4). CONCLUSION: The 5-year overall survival rate was found to be 21%. The finding was remarkably lower than other published reports. Survival among acute leukemia patients was significantly associated with older age, history of relapse, hepatomegaly, splenomegaly, as well as certain subtypes. Therefore, improving early detection and initiation of treatment for all acute leukemia patients is necessary in order to improve patient's survival status.

Satisfaction with preoperative education and surgical services among adults elective surgical patients at selected public hospitals in Addis Ababa, Ethiopia.

Objectives: The purpose of this study was to determine the level of satisfaction with preoperative education and surgical services among adult elective surgical patients at governmental hospitals in Addis Ababa, Ethiopia. Methods: Four hundred and twenty-two elective surgical patients at Addis Ababa's governmental hospitals took part in a facility-based cross-sectional study from 8 October to 8 November 2021. Based on past experiments, an instrument for structured data collection was modified and employed. The data were cleaned and sent to Epidata version 4.2 before being exported and analysed in SPSS version 25. Descriptive statistics were used to describe the participant characteristics, and logistic regression, which also included bivariate and multivariate analysis, was used to evaluate the association between the independent and outcome variables. The level of statistical significance was indicated by a p value of 0.05. Results: 84.6% of the participants reported feeling very satisfied with their preoperative education. Preoperative education about surgery (adjusted odds ratios (AOR) = 0.005; 95% confidence interval (CI): (0.000, 0.061)), previous surgery (AOR = 2.7; 95% CI: (2.51, 6.85)), and preoperative anxiety (AOR = 0.013; 95% CI: (0.003, 0.06)) were all significantly associated. Conclusions: About 84% of survey participants reported being satisfied with preoperative education and services. Preoperative patient satisfaction was negatively predicted by preoperative anxiety, prior surgery, and preoperative information about surgery. The decrease of anxiety and enhancement of surgical patient satisfaction may be significantly impacted by proper preoperative education.

Determinants of traditional medicine utilization for children: a parental level study in Tole District, Oromia, Ethiopia.

BACKGROUND: In Ethiopia, about 80% of the population use traditional medicine (TM) due to the cultural acceptability of healers and local pharmacopeias, the relatively low cost of traditional medicine, and the difficulty of accessing modern health facilities. This study was aimed at assessing traditional medicine utilization and its determinants among parents of the children employing a case study of the Tole District of South West of Oromia, Ethiopia. METHODS: A community-based cross-sectional data were collected from 267 parents who have children less than 18 years old. The respondents were selected through a systematic random sampling technique. Both descriptive and exploratory techniques were used to analyze the data. The exploratory logistic regression analysis was carried out to identify factors determining the use of traditional medicine (TM). RESULTS: We found out that 85.9% of parents used TM for their children. Herbal medicine 73 (34.4%), massage 55 (25.9%), and religious/prayer therapy 25 (11.8%) were the major therapies used by parents for their children. In the study area, the rate of parental TM utuilization for their children was determined by monthly income [OR: 0.25(0.08, 0.78)], cultural belief [OR: 3.01(1.16, 7.83)], religious belief [OR = 3.17(1.26, 7.93)], and duration of illness [OR = 3.11(1.07, 9.02)]. CONCLUSION: Traditional medicine use is highly prevalent that its contribution to the public health is significant as some could not access to and afford modern health services in the area. Therefore, health professionals should advise parents side-by-side procuring modern health services. In light of this, further research will be needed on the safety and efficacy of TM for wider application.