[Efficacy of danazol in autoimmune hemolytic anemia with cold agglutinins. 4 cases]. / Efficacité du danazol dans l'anémie hémolytique auto-immune avec agglutinines froides. 4 observations.

The treatment of haemolytic anaemia related to primary cold agglutinin disease is often unsatisfactory. Corticosteroids are not useful in most cases and, beside protection against cold, treatment is frequently limited to transfusions. We report the good results obtained with long-term danazol therapy (600 mg per day initially, than 400 mg per day) in 3 cases of chronic cold agglutinin disease and 1 case of idiopathic haemolytic anaemia with cold agglutinin in serum. The only side-effect was a transient increase of transaminase level requiring reduction of a maintenance dose which could be given during 3 to 7 years.

[Carpal tunnel syndrome in patients with chronic renal insufficiency treated by hemodialysis]. / Le syndrome du canal carpien chez l'insuffisant rénal chronique traité par hémodialyse.

Carpal tunnel syndrome in patients with chronic renal failure under dialysis has been described lately. Its frequency, in the literature, varies between 2 and 15%. In our study, 12 patients of 283 (4.7%) developed symptoms of carpal tunnel syndrome. Cases are evenly distributed between male and female patients. The course is serious, since half the patients required surgery. Pathogenetic hypotheses include ischemia and vascular steal, edema, and amyloïdosis. Uremic peripheral neuropathy and carpal tunnel syndrome are independent.