ABSTRACT
PV-88 is the Ca2+ L channel blocker from pyrrole compounds, that has been used at hemorrhagic shock - HS (model of Shock was created by the method of (Wiggers-Feine) on 60th minute (intravenous administration, 3 mg/kg). Mean arterial pressure was 40 mmHg. Effects were studied on 80th minute after blood letting. Blood was exfused 40 ml/kg. Effect of PV-88 on redox processes in liver was studied. Experiments were carried out on male cats. Right lobe of the liver and the metabolic indices: ATP, CO, NAD, NADP, ALP, SDH, LDH were studied with the use of histochemistry (Pearse). Investigations have shown that on 80th minute after PV-88 administration CO (p<0.05), NADP (p<0.05), ALP (p<0.001), SDH (p<0.05), and LDH (p>0.05) were increased, while ATP (p<0.001) and NAD (p<0.001) were decreased. Increase in LDH was not statistically significant. According to the results of investigations, after administration of PV-88 at HS 60 on 80th minute, in liver increases oxygen concentration and aerobic process respectively.
Subject(s)
Blood Pressure/drug effects , Calcium Channel Blockers/pharmacology , Shock, Hemorrhagic/metabolism , Adenosine Triphosphate/metabolism , Animals , Calcium Channel Blockers/administration & dosage , Cats , Cytochromes/metabolism , L-Lactate Dehydrogenase/metabolism , Liver/drug effects , Liver/enzymology , Male , Models, Animal , NAD/metabolism , NADP/metabolism , Oxidation-Reduction , Oxygen/metabolism , Time FactorsABSTRACT
The aim of the study is to reveal and treat the side effects of the combined antiviral therapy - Peginterferon and Ribavirin in patients with chronic Hepatitis C. During 2004-2006 years, 40 patients in the ambulatory department of the Infectious Diseases Clinic of the State Medical University were investigated. All the patients were administered pegilated interferon and ribavirin after special procedures. The following side effects on the antiviral treatment were grouped: flu-like, cardiovascular, gastrointestinal, neuro-psychiatric, dermatological and hematological. Frequency, severity and duration of all unfavorable symptoms were independent of Hepatitis C genotype, though the adherence to the medications was better in younger age groups and the dose correction where required after the age 45.
Subject(s)
Antiviral Agents/adverse effects , Hepatitis C, Chronic/drug therapy , Interferon-alpha/adverse effects , Polyethylene Glycols/adverse effects , Ribavirin/adverse effects , Adult , Antiviral Agents/therapeutic use , Female , Humans , Interferon alpha-2 , Interferon-alpha/therapeutic use , Male , Middle Aged , Polyethylene Glycols/therapeutic use , Recombinant Proteins , Ribavirin/therapeutic useABSTRACT
Liver cirrhosis and hepatocellular carcinoma are the most frequent and severe complications of chronic hepatitis C. Results of recent investigations indicate that HCV persists and replicates not only in hepatic tissue, but in the other organs as well. The goal of our investigation was to determine hematological disorders during chronic HCV and HCV+HBV hepatitis, to find correlation between activity of chronic hepatitis, stage of cirrhosis, and degree of hematological disorders. We have studied patients with chronic C and B+C hepatitis (36 persons) and 77 HCV-infected persons on the stage of cirrhosis. The erythrocytes morphology was investigated using light microscope. The osmotic resistance of erythrocytes was investigated using the method of Ianovski (modification of Ribiera); the thrombocytes' ability to adhere and aggregate was studied by Rite's method. The absolute number of thrombocytes was counted by means of phase-contrast microscope. Our investigation suggests that there is no absolute correlation between chronic hepatitis C activity and hematological disorders and often the degree of extrahepatocellular disorders is higher than the degree of liver damage.
Subject(s)
Hematologic Diseases/etiology , Hepatitis B, Chronic/complications , Hepatitis C, Chronic/complications , Adolescent , Adult , Aged , Enzyme-Linked Immunosorbent Assay , Erythrocytes/physiology , Female , Hematologic Tests , Hepatitis B, Chronic/blood , Hepatitis B, Chronic/diagnosis , Hepatitis B, Chronic/immunology , Hepatitis C, Chronic/blood , Hepatitis C, Chronic/diagnosis , Hepatitis C, Chronic/immunology , Humans , Liver Cirrhosis/complications , Male , Middle Aged , Platelet Adhesiveness , Platelet Aggregation , Platelet Count , Viral LoadABSTRACT
A study was made of HB-virus infection markers in 438 patients of different age with hepatitis B. Highly sensitive methods based on the test systems manufactured in this country and abroad were employed. The authors established the diagnostic importance of HBV markers, studied the prevalence of those markers in parents of the diseased children of the first year of life, demonstrated the clinico-epidemiological importance of highly sensitive methods of serological diagnosis.
