ABSTRACT
OBJECTIVES: Epstein-Barr virus (EBV) infection is associated with multiple sclerosis (MS), and EBV may transform lymphoblastoid cell lines more frequently in MS patients than controls, but it is not clear whether this reflects a higher viral load or an enhanced ability to reactivate EBV. MATERIAL AND METHODS: MS patients and controls were examined for their B-cell subsets and during 16 weeks for spontaneous lymphocyte transforming events. RESULTS: MS patients had normal distribution of B-cell subsets, but a significantly higher incidence of B-cell transforming events, which occurred with kinetics similar to controls. CONCLUSIONS: The higher incidence suggests an increased frequency of latent EBV-infected B cells in MS.
Subject(s)
B-Lymphocytes/immunology , B-Lymphocytes/virology , Epstein-Barr Virus Infections/immunology , Herpesvirus 4, Human/immunology , Multiple Sclerosis/immunology , Multiple Sclerosis/virology , Adult , Case-Control Studies , Denmark/epidemiology , Epstein-Barr Virus Infections/blood , Epstein-Barr Virus Infections/epidemiology , Epstein-Barr Virus Infections/virology , Female , Flow Cytometry , Humans , Incidence , Lymphocyte Activation , Male , Multiple Sclerosis/blood , Multiple Sclerosis/epidemiologySubject(s)
Aspirin/pharmacology , Cyclooxygenase Inhibitors/pharmacology , Drug Resistance , Platelet Aggregation Inhibitors/pharmacology , Platelet Aggregation/drug effects , Platelet Function Tests/instrumentation , Artifacts , Blood Platelets/enzymology , Cyclooxygenase 1/blood , Follow-Up Studies , Humans , Peripheral Vascular Diseases/blood , Reproducibility of Results , Rheology , Stress, MechanicalABSTRACT
A 28-year-old woman (gravida 2, para 2) was admitted 20 months after a hysterectomy because of fibromyoma. The hysterectomy specimen had shown intravenous leiomyomatosis. The patient presented with unspecific abdominal symptoms, serologic signs of hepatic and renal failure and clinical right-sided heart failure. Progression despite treatment with a gonadotropin-releasing hormone analogue promoted transferral to the present centre. Abdominal ultrasonography, phlebography and transoesophageal echocardiography showed a left pelvic mass and a seemingly free-floating tumour extending from the left main iliac vein via the inferior caval vein to the right ventricle. During a combined cardiac and distal caval approach using extracorporeal circulation, a 45 cm massive leiomyoma was removed successfully. Seven weeks later the left pelvic tumour was removed radically together with left oophorectomy. At control 12 months later the patient was well and without any remaining symptoms.
Subject(s)
Heart Ventricles/pathology , Leiomyomatosis/pathology , Neoplasm Recurrence, Local/pathology , Uterine Neoplasms/pathology , Vena Cava, Inferior/pathology , Adult , Female , Humans , Leiomyomatosis/surgery , Uterine Neoplasms/surgeryABSTRACT
Minimal invasive surgery has many benefits, and its application in different areas of surgery is still widening. This paper describes the results of treatment of varicoceles with laparoscopic technique on a day-in day-out basis. The operative time was acceptable and decreased with experience. The postoperative morbidity was low and time of convalescence short making the operation suitable for an out-patient regime, which again justifies the extra costs.
