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1.

Proteomics: one small step for a digital computer, one giant leap for humankind.

Geisow, M J.

Nat Biotechnol ; 16(2): 206, 1998 Feb.

Article in English | MEDLINE | ID: mdl-9487532

Subject(s)

Computer Communication Networks , Genome , Proteins/genetics , Drug Design , Drug Industry , Electrophoresis, Gel, Two-Dimensional

2.

Mass spectrometry in the standardisation of recombinant products.

Geisow, M J.

Dev Biol Stand ; 83: 129-33, 1994.

Article in English | MEDLINE | ID: mdl-7883085

Subject(s)

Mass Spectrometry/methods , Recombinant Proteins/standards , Animals , Biotechnology/standards , Drug Contamination , Humans , Molecular Weight , Protein Processing, Post-Translational , Quality Control , Recombinant Proteins/chemistry , Recombinant Proteins/metabolism

3.

Molecular couturiers and designer proteins.

Geisow, M J.

Trends Biotechnol ; 11(4): 111-4, 1993 Apr.

Article in English | MEDLINE | ID: mdl-7765301

Subject(s)

Protein Engineering , Amino Acid Sequence , Humans , Molecular Sequence Data , Protein Conformation

4.

Harmonizing viewpoints on ensuring the consistency and stability of rDNA-derived biologicals.

Corran, P H; Griffiths, E; Robertson, J S; Geisow, M J.

Trends Biotechnol ; 11(3): 77-80, 1993 Mar.

Article in English | MEDLINE | ID: mdl-7765294

Subject(s)

Biological Products/standards , DNA, Recombinant , Animals , Biological Products/genetics , DNA, Recombinant/genetics , DNA, Recombinant/metabolism , DNA, Recombinant/therapeutic use , Humans , Quality Control

5.

Mass measurement at high molecular weight--new tools for biotechnologists.

Geisow, M J.

Trends Biotechnol ; 10(12): 432-41, 1992 Dec.

Article in English | MEDLINE | ID: mdl-1369133

ABSTRACT

It has long been possible to analyse small molecules accurately and reproducibly by mass-spectrometric techniques. Two new techniques extend the application of mass spectrometry to proteins and other biopolymers of high molecular mass. The accuracy, sensitivity and resolving power of these new methods permits the detection of minor, but biologically significant protein modifications.

Subject(s)

Mass Spectrometry/methods , Biotechnology , Carbohydrate Sequence , Electricity , Humans , Lasers , Molecular Sequence Data , Molecular Weight , Polysaccharides/chemistry , Proteins/chemistry

6.

Pores for thought in bioseparation and bioassay matrices.

Geisow, M J.

Trends Biotechnol ; 10(11): 373-5, 1992 Nov.

Article in English | MEDLINE | ID: mdl-1368877

Subject(s)

Proteins/isolation & purification , Chromatography, High Pressure Liquid , Enzyme-Linked Immunosorbent Assay , Membranes, Artificial

7.

Human serum albumin structure--solved.

Geisow, M J.

Trends Biotechnol ; 10(10): 335-7, 1992 Oct.

Article in English | MEDLINE | ID: mdl-1368871

Subject(s)

Serum Albumin/chemistry , Humans , Protein Conformation

8.

Glycoprotein glycans--roles and controls.

Geisow, M J.

Trends Biotechnol ; 10(10): 333-5, 1992 Oct.

Article in English | MEDLINE | ID: mdl-1368870

Subject(s)

Glycoproteins/physiology , Polysaccharides/physiology , Animals , Erythropoietin/physiology , Glycosylation , Humans , In Vitro Techniques , Tissue Plasminogen Activator/physiology

9.

Are you being served?

Geisow, M J.

Trends Biotechnol ; 10(9): 297-9, 1992 Sep.

Article in English | MEDLINE | ID: mdl-1369083

Subject(s)

Biotechnology , Biotechnology/economics , Biotechnology/organization & administration , Industry , International Agencies , International Cooperation , Research Support as Topic

10.

Antibody engineering--successful affinity maturation in vitro.

Geisow, M J.

Trends Biotechnol ; 10(9): 299-301, 1992 Sep.

Article in English | MEDLINE | ID: mdl-1369084

Subject(s)

Antibodies, Viral/genetics , Antibody Affinity/genetics , Protein Engineering/methods , Antibodies, Viral/biosynthesis , Biotechnology , Cloning, Molecular , Genes, Immunoglobulin , Humans

11.

Codon 65--unnatural success in protein biosynthesis.

Geisow, M J.

Trends Biotechnol ; 10(8): 265-6, 1992 Aug.

Article in English | MEDLINE | ID: mdl-1368375

Subject(s)

Codon , Protein Engineering , Amino Acid Sequence , Base Sequence , Cytidine/chemistry , DNA , Molecular Sequence Data

12.

Progress in engineering HbA--a molecular resuscitator.

Geisow, M J.

Trends Biotechnol ; 10(8): 266-7, 1992 Aug.

Article in English | MEDLINE | ID: mdl-1368376

Subject(s)

Blood Substitutes , Hemoglobins/biosynthesis , Humans , Protein Engineering

13.

What's cooking? Optimizing bioprocess monitoring.

Geisow, M J.

Trends Biotechnol ; 10(7): 230-2, 1992 Jul.

Article in English | MEDLINE | ID: mdl-1368319

Subject(s)

Biological Products/analysis , Animals , Chromatography, High Pressure Liquid , Fermentation , Flow Injection Analysis , Humans

14.

Inspired respiratory solutions.

Geisow, M J.

Trends Biotechnol ; 10(6): 181-2, 1992 Jun.

Article in English | MEDLINE | ID: mdl-1379819

Subject(s)

Cystic Fibrosis/therapy , alpha 1-Antitrypsin Deficiency , Biotechnology , Cystic Fibrosis/genetics , Cystic Fibrosis Transmembrane Conductance Regulator , Genetic Therapy , Humans , Membrane Proteins/genetics , alpha 1-Antitrypsin/genetics

15.

Shaping up for a bright future: protein analysis and design.

Geisow, M J.

Trends Biotechnol ; 10(5): 141-4, 1992 May.

Article in English | MEDLINE | ID: mdl-1368315

Subject(s)

Proteins/analysis , Proteins/chemistry , Amino Acid Sequence , Base Sequence , Biotechnology/trends , DNA/chemistry , Drug Design , Humans , Molecular Sequence Data , Protein Binding , Protein Conformation , Protein Engineering

16.

Bioactive peptides from 'alphabet soup'.

Geisow, M J.

Trends Biotechnol ; 10(4): 110-1, 1992 Apr.

Article in English | MEDLINE | ID: mdl-1374261

Subject(s)

Peptides/chemistry , Epitopes , Heat-Shock Proteins/chemistry , Heat-Shock Proteins/immunology , Heat-Shock Proteins/metabolism , Peptides/immunology , Peptides/metabolism , Protein Binding , Protein Conformation

17.

Aching for approval, hoping for harmony--biotech product regulation.

Geisow, M J.

Trends Biotechnol ; 10(4): 107-8, 1992 Apr.

Article in English | MEDLINE | ID: mdl-1368093

Subject(s)

Biotechnology , Legislation, Drug , Clinical Trials as Topic , Humans , United States , United States Food and Drug Administration

18.

Improved selection systems for man-made antibodies.

Geisow, M J.

Trends Biotechnol ; 10(3): 75-6, 1992 Mar.

Article in English | MEDLINE | ID: mdl-1367942

Subject(s)

Antibodies/therapeutic use , Drug Evaluation, Preclinical , Humans

19.

The human genome: beyond the bases.

Geisow, M J.

Trends Biotechnol ; 10(3): 77-8, 1992 Mar.

Article in English | MEDLINE | ID: mdl-1367943

Subject(s)

Genome, Human , Biotechnology/economics , Databases, Bibliographic , Humans

20.

Of mice and mimics.

Geisow, M J.

Trends Biotechnol ; 9(12): 404-5, 1991 Dec.

Article in English | MEDLINE | ID: mdl-1367742

Subject(s)

Antibodies, Monoclonal/metabolism , Receptors, Virus/metabolism , Animals , Binding Sites, Antibody , Mice , Molecular Conformation , Reoviridae/metabolism

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