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1.
J Heart Valve Dis ; 24(4): 478-83, 2015 Jul.
Article in English | MEDLINE | ID: mdl-26897820

ABSTRACT

BACKGROUND AND AIM OF THE STUDY: In patients undergoing the Ross procedure, the right ventricular outflow tract (RVOT) conduit is inserted in an orthotopic position rather than in the more heterotopic position used in the repair of complex congenital RVOT obstruction. The study aim was to compare the authors' institutional mid-term experience of large-sized homografts (>19 mm) in patients with Ross and non-Ross RVOT reconstructions. METHODS: The outcome was reviewed of all homografts implanted for Ross (n = 72) or non-Ross (n = 64) RVOT reconstruction at a single center between 1993 and 2012. Echocardiographic data were reviewed to evaluate valve performance. Homograft dysfunction was defined as RVOT obstruction with peak echo-Doppler gradient >40 mmHg and/or grade >III/IV conduit valve regurgitation. Homograft failure was defined as the need for conduit replacement or catheter or surgical reintervention. RESULTS: The age, body weight, conduit diameter and previous surgery were significantly higher in patients with Ross compared to the non-Ross group (p = 0.002, 0.003 and <0.001, respectively). The mean follow up duration was similar in both groups. There were 35 re-interventions (Ross, n = 17; non-Ross, n = 18). The data acquired showed actuarial survival, freedom from conduit dysfunction and conduit failure to be similar in both cohorts. Freedom from any type of reoperation was worse for the Ross group (58%) than for the non-Ross group (72%) (p = 0.05). CONCLUSION: During the first 15 years after Ross or non-Ross pulmonary homograft implantation, the survival rate, freedom from failure and dysfunction, and RVOT gradient were statistically similar. Freedom from any type of reoperation was significantly higher in the non-Ross group, however.


Subject(s)
Bioprosthesis , Blood Vessel Prosthesis Implantation/instrumentation , Blood Vessel Prosthesis , Heart Defects, Congenital/surgery , Heart Valve Prosthesis Implantation/instrumentation , Heart Valve Prosthesis , Plastic Surgery Procedures/instrumentation , Pulmonary Artery/surgery , Pulmonary Valve/surgery , Adolescent , Allografts , Blood Vessel Prosthesis Implantation/adverse effects , Blood Vessel Prosthesis Implantation/methods , Blood Vessel Prosthesis Implantation/mortality , Child , Child, Preschool , Disease-Free Survival , Echocardiography, Doppler , Female , Heart Defects, Congenital/diagnosis , Heart Defects, Congenital/mortality , Heart Valve Prosthesis Implantation/adverse effects , Heart Valve Prosthesis Implantation/methods , Heart Valve Prosthesis Implantation/mortality , Humans , Illinois , Kaplan-Meier Estimate , Male , Prosthesis Design , Prosthesis Failure , Pulmonary Artery/physiopathology , Pulmonary Valve/physiopathology , Plastic Surgery Procedures/adverse effects , Plastic Surgery Procedures/methods , Plastic Surgery Procedures/mortality , Reoperation , Retrospective Studies , Risk Factors , Time Factors , Treatment Outcome
2.
J Card Surg ; 29(5): 698-704, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25081042

ABSTRACT

OBJECTIVES: Tricuspid valve regurgitation (TR) is a common finding in children with hypoplastic left heart syndrome (HLHS) undergoing staged surgical reconstruction and can result from either abnormal valve morphology or incomplete leaflet coaptation due to annular dilatation. The purpose of this study was to determine the incidence of severe TR and to evaluate the effect of surgically treated tricuspid valve (TV) disease on overall survival. METHODS: Between December 1988 and December 2012, 86 patients with HLHS underwent a Norwood procedure (mean age/weight, 11.1 days/3.5 kg). Thirty-five percent had associated congenital cardiac, structural, and genetic anomalies. Subsequently, 65 patients underwent a bidirectional Glenn procedure or a hemi-Fontan (stage II) and 42 patients a modified Fontan procedure (stage III). The mean follow-up was 6.6 years. All patients were evaluated preoperatively and postoperatively by Doppler echocardiography to determine the degree of TR. RESULTS: At the time of discharge following the Norwood procedure, 64% (n = 47) of the patients had none/trivial, 32% (n = 24) had mild, 3% had moderate (n = 2), and 1% (n = 1) had severe TR on their post-Norwood Doppler echocardiograms. Among 74 Norwood survivors, 11 children (15%) with severe TR underwent TV repair at a median interval after the Norwood procedure of nine months (range, 2-70). There were one surgical and one late death, giving an overall mortality of 18%. The overall survival rate between TR and non-TR repair groups was not significantly different (p = 0.18). Four patients (36%) underwent reoperation for persistent TR. CONCLUSIONS: Severe TR as a risk factor for mortality in children undergoing palliative procedures for HLHS can be diminished by successful TV procedures. Survival at intermediate follow-up of patients with successful TV procedures that eliminate severe TR and patients without a history of severe TR are similar. Further follow-up is required to determine the impact of surgically treated TR on long-term survival and the durability of surgical techniques.


Subject(s)
Hypoplastic Left Heart Syndrome/surgery , Tricuspid Valve Insufficiency/surgery , Tricuspid Valve/surgery , Cardiac Surgical Procedures/methods , Female , Follow-Up Studies , Humans , Hypoplastic Left Heart Syndrome/complications , Hypoplastic Left Heart Syndrome/mortality , Incidence , Infant , Infant, Newborn , Male , Retrospective Studies , Severity of Illness Index , Survival Rate , Time Factors , Treatment Outcome , Tricuspid Valve Insufficiency/epidemiology , Tricuspid Valve Insufficiency/etiology , Tricuspid Valve Insufficiency/mortality
3.
Ann Thorac Surg ; 98(1): 112-8, 2014 Jul.
Article in English | MEDLINE | ID: mdl-24725835

ABSTRACT

BACKGROUND: Autograft dilatation (AD) and aortic insufficiency (AI) after the Ross procedure are the most common causes of late autograft failure. The purpose of this study was to examine the results of valve-sparing root replacement (modified David) and composite root replacement. METHODS: We performed a retrospective review of all children (n=78) undergoing a Ross procedure at our Center from 1993 to 2011. RESULTS: Median follow-up was 10 years (1to 18 years). Freedom from autograft reoperation was 94% at 5 years, and 65% at 15 years. Freedom from greater than 2+ autograft AI was 93% at 5 years and 76% at 15 years. Autograft reoperation was necessary in 22 patients, at a median interval of 8.7 years after the original procedure. Indications for reoperation were AI with autograft dilatation in 15 patients, AI without dilatation in 2 patients, and AD without AI in 5 patients. Surgical procedures used at reoperation included valve-sparing root replacement in 14 patients, root replacement either mechanical or biologic valved conduit in 6 patients, and valve replacement in 2 patients. At a mean follow-up of 5.8 years after reoperation, 4 patients from the valve-sparing group underwent second reoperation (valve replacement). Freedom from second autograft reoperation was 71% for patients after a valve sparing procedure and 100% for patients after an aortic valve or root replacement (Bentall procedure) at 5 years. CONCLUSIONS: Autograft valve-sparing root replacement and composite aortic root replacement are effective treatments for aortic root dilation and AI after the Ross procedure. The potential of late autograft insufficiency after valve-sparing root replacement warrants annual follow-up.


Subject(s)
Cardiac Surgical Procedures/adverse effects , Forecasting , Graft Rejection/surgery , Heart Valve Diseases/surgery , Heart Valves/transplantation , Adolescent , Cardiac Surgical Procedures/methods , Child , Child, Preschool , Echocardiography, Doppler, Color , Female , Follow-Up Studies , Graft Rejection/diagnosis , Graft Rejection/epidemiology , Humans , Illinois/epidemiology , Incidence , Infant , Infant, Newborn , Male , Reoperation , Retrospective Studies , Time Factors , Transplantation, Autologous/adverse effects
4.
Pediatr Cardiol ; 35(1): 96-102, 2014 Jan.
Article in English | MEDLINE | ID: mdl-23925414

ABSTRACT

Recent studies have suggested that survival after the modified Norwood procedure is influenced by anatomy and is worse for patients with hypoplastic left heart syndrome (HLHS) than for patients with other forms of functional single ventricle. This study aimed to compare the outcomes of the modified Norwood procedure for these two groups at a single center. A retrospective chart review compared modified Norwood procedure outcomes between children with HLHS (n = 40) and children with other single-ventricle malformations (n = 19) from January 2002 to August 2012. The HLHS patients had a lower mean age (10.0 ± 13.2 days) at the time of operation than the non-HLHS patients (16.5 ± 18.5 days). The difference was not significant. The number of patients with a Sano modification was significantly higher in the HLHS group (HLHS 85 % vs non-HLHS 32 %; p < 0.001). The follow-up data did not differ between the groups (HLHS 3.6 ± 3.2 years vs non-HLHS 4.8 ± 3.3 years, nonsignificant difference). The overall operative survival was 85 %: 83 % for the patients with HLHS and 89 % for the patients with non-HLHS (nonsignificant difference). The Kaplan-Meier transplant-free survival estimate at 10 years was 73 % and did not differ between the HLHS patients (67 %) and the non-HLHS patients (84 %, nonsignificant difference). The timing of stages 2 and 3 palliation (bidirectional Glenn and external conduit Fontan) did not differ significantly (HLHS, 7.0 ± 2.8 months and 3.0 ± 0.5 years vs non-HLHS 6.1 ± 1.7 months and 2.8 ± 0.8 years). The two groups were similar with respect to the need for post-Norwood extracorporeal membrane oxygenation support, aortic arch reinterventions, atrioventricular valve repair, pulmonary artery reconstruction, pacemaker implantation, and progression to bidirectional Glenn and Fontan completion. The modified Norwood reconstruction provides good palliation for HLHS as well as other forms of functional single-ventricle anatomy. Survival, postoperative morbidity, and progression to Glenn and Fontan are not significantly different.


Subject(s)
Heart Ventricles , Hypoplastic Left Heart Syndrome/surgery , Norwood Procedures , Postoperative Complications , Vascular Surgical Procedures , Ventricular Outflow Obstruction , Comparative Effectiveness Research , Female , Heart Ventricles/abnormalities , Heart Ventricles/surgery , Humans , Infant , Infant, Newborn , Intraoperative Care/methods , Kaplan-Meier Estimate , Male , Norwood Procedures/adverse effects , Norwood Procedures/methods , Norwood Procedures/mortality , Outcome Assessment, Health Care , Palliative Care/methods , Postoperative Complications/classification , Postoperative Complications/diagnosis , Postoperative Complications/surgery , Proportional Hazards Models , Retrospective Studies , United States/epidemiology , Vascular Surgical Procedures/adverse effects , Vascular Surgical Procedures/methods , Ventricular Outflow Obstruction/congenital , Ventricular Outflow Obstruction/surgery
5.
J Card Surg ; 28(5): 569-75, 2013 Sep.
Article in English | MEDLINE | ID: mdl-23837452

ABSTRACT

OBJECTIVE: Patients with double inlet left ventricle (DILV)/transposition and similar morphologies have their systemic outflow traverse a bulboventricular foramen (BVF), which has a propensity to narrow over time. The aim of this study is to evaluate the outcomes of initial pulmonary artery banding (PAB) compared with the Norwood-type reconstruction in neonates. METHODS: A retrospective study of children with DILV and similar morphologies presenting between 1982 and 2012. The outcomes of initial PAB (n=17) are compared with a Norwood-type reconstruction (n=20). The two groups were similar with respect to age, gender, weight, noncardiac syndromes, and Fontan completion. Mean follow-up was longer in PAB patients (13.3 ± 9.8 years) versus Norwood (4.5 ± 3.0 years, p=0.001). RESULTS: Survival was 75% at eight years in the Norwood group versus 71% in the PAB group (p=0.76). Mortality in the Norwood group was higher before 2002 (p=0.06). The age of patients who underwent a bidirectional Glenn shunt was significantly higher for PAB group (PAB, 9.1 ± 1.4 months vs. Norwood, 6.1 ± 1.6 months; p<0.001). Freedom from any type of reintervention (systemic outflow obstruction or coarctation) was similar (Norwood, 83% vs. PAB, 71%; p=0.62). Freedom from heart block with a pacemaker insertion was significantly better for Norwood patients (Norwood, 89% vs. PAB, 41%; p=0.001). CONCLUSIONS: The Norwood-type reconstruction provides good palliation in this subgroup of patients and avoids the need for subsequent intracardiac operations, maintaining an unobstructed systemic outflow tract and avoiding the risk of heart block. Survival does not differ depending on the type of procedure. Patients with PAB show comparable satisfactory early and long-term results, with an increasing reoperation risk and heart block remaining a major concern.


Subject(s)
Cardiac Surgical Procedures/methods , Heart Ventricles/abnormalities , Heart Ventricles/surgery , Plastic Surgery Procedures/methods , Pulmonary Artery/surgery , Transposition of Great Vessels/surgery , Vascular Surgical Procedures/methods , Ventricular Outflow Obstruction/surgery , Cardiac Surgical Procedures/mortality , Female , Follow-Up Studies , Humans , Infant, Newborn , Male , Plastic Surgery Procedures/mortality , Retrospective Studies , Survival Rate , Time Factors , Treatment Outcome , Vascular Surgical Procedures/mortality
6.
J Heart Valve Dis ; 22(2): 209-14, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23798210

ABSTRACT

BACKGROUND AND AIM OF THE STUDY: A variety of valve substitutes has been used for right ventricular outflow tract (RVOT) reconstruction in children and young adults following previous RVOT surgery that has led to significant pulmonary insufficiency and/or stenosis. Herein, the authors' experience with pulmonary valve replacement (PVR) using a stented bovine pericardial xenograft late after previous RVOT surgery was reviewed. METHODS: Between 2000 and 2011, a total of 49 patients (mean age 22.4 +/- 12.3 years; range: 5-50 years) underwent PVR using stented bovine pericardial xenografts. All patients had prior RVOT reconstruction; these patients averaged two prior operations (range: 1-4) for the following diagnoses: tetralogy of Fallot (n = 28), pulmonary atresia (n = 6), pulmonary stenosis (n = 6), transposition of the great arteries (n = 3), truncus arteriosus (n = 1), and others (n = 5). Of these patients, 24 (49%) underwent additional procedures at the time of pulmonary valve insertion. RESULTS: There was no early death, but six late deaths. The overall survival rate was 88% at 10 years. All surviving patients were well at a mean follow up of 4.0 +/- 2.3 years (range: 6 months to 10 years). Echocardiography showed trivial or no pulmonary insufficiency in 22 patients (56%). The calculated mean peak systolic RVOT gradient at the last follow up by echocardiography was 22.7 +/- 6.6 mmHg. Freedom from RVOT reintervention and xenograft explantation was 94% and 98% at 10 years, respectively. CONCLUSION: The stented bovine pericardial xenografts demonstrated excellent intermediate-term results for repeat RVOT reconstruction. The hemodynamic characteristics of this valve are comparable to those of allografts, and the xenograft represents is an attractive alternative given the limited availability of allografts. The stented bovine pericardial xenograft remains an ideal valve choice for teenagers and young adults with congenital abnormalities of the RVOT, especially for redo as a second or third choice.


Subject(s)
Bioprosthesis , Heart Valve Prosthesis Implantation , Pulmonary Valve Insufficiency/surgery , Pulmonary Valve Stenosis/surgery , Ventricular Outflow Obstruction/surgery , Adolescent , Adult , Child , Child, Preschool , Female , Heart Valve Prosthesis , Humans , Male , Middle Aged , Pulmonary Valve , Reoperation/statistics & numerical data , Retrospective Studies , Stents , Treatment Outcome , Young Adult
7.
Ann Thorac Surg ; 95(2): 670-5, 2013 Feb.
Article in English | MEDLINE | ID: mdl-23103011

ABSTRACT

BACKGROUND: For children who require aortic valve replacement, the pulmonary autograft (Ross procedure) may be the ideal substitute. However, performing a modified Konno procedure at the time of autograft implantation (Ross-Konno) may be associated with significant morbidity and mortality. A retrospective study was undertaken to compare the outcomes of Ross-Konno (RK) and the Ross (R) procedures including the need for reinterventions and long-term survival. METHODS: Between 1993 and 2011, 78 children (mean age, 11.1 ± 5.6 years; range, 1 week to 18 years) underwent the Ross procedure. Modified Konno-type enlargement of the left ventricular outflow tract was performed in 18 of those patients. RESULTS: There was no statistically significant difference between the groups with respect to pathologic process, sex, concomitant procedures, and aortic gradient. Our data demonstrate that mean age (R, 12.9 years versus RK, 5.3 years; p < 0.001), mean size of allograft (R, 23.3 mm versus RK, 20.1 mm; p < 0.001), previous surgery (R, 51% versus RK, 83%; p = 0.05), and postoperative morbidity (R, 3% versus RK, 28%; p = 0.003) were significantly different between the groups. There were 3 hospital deaths (all RK with mitral valve anomalies). Actuarial survival at 10 years was significantly better for Ross patients than Ross-Konno (R, 96% versus RK, 72%; p = 0.001). Freedom from autograft, right ventricular outflow tract obstruction, and cumulative reoperations at 10 years were not significantly different between groups. CONCLUSIONS: The risk of death and postoperative complications after the Ross-Konno procedure is higher than for the Ross procedure. Preoperative complexity (including mitral valve anomalies) is associated with significantly higher morbidity and mortality. Autograft insufficiency and right ventricular outflow tract obstruction are common postoperative complications, requiring reoperation in one quarter of patients, but these were not significantly different between the groups.


Subject(s)
Aortic Valve Insufficiency/surgery , Aortic Valve Stenosis/surgery , Ventricular Outflow Obstruction/surgery , Adolescent , Aortic Valve Insufficiency/complications , Aortic Valve Stenosis/complications , Cardiac Surgical Procedures/methods , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Retrospective Studies , Risk Factors , Ventricular Outflow Obstruction/complications
8.
Ann Thorac Surg ; 94(5): 1604-11, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22795061

ABSTRACT

BACKGROUND: We analyzed the outcome of children and young adults (younger than 40 years) with aortic valve disease who underwent allograft or autograft aortic root replacement (ARR) in our institution and evaluated whether there is a preference for either valve substitute. METHODS: One-hundred fifty patients younger than 40 years underwent ARR between January 1990 and July 2011. Forty-four patients, aged 18.8 ± 12.4 years, had ARR with allograft conduit (allograft group), whereas 106 patients, aged 17.9 ± 11 years (p = 0.63), had a Ross ARR during the same period of time (autograft group). Echocardiographic data were reviewed to evaluate valve performance. The 2 groups were similar with respect to age, gender, etiology, and previous and concomitant procedures. RESULTS: Operative deaths were 3 in the autograft group. There were 6 late deaths in the autograft group and 5 in the allograft group. Survival was 92% and 84% at 5 and 15 years, respectively, in the allograft group versus 93% and 91% in the autograft group (p = 0.42). Freedom from any type of reintervention and from reoperation on aortic valve were similar (autograft, 64% and 72% versus allograft, 66% and 66%; p = not significant) at 15 years. Freedom from explantation were significantly better for Ross patients (autograft, 82% versus allograft, 66%; p = 0.05). CONCLUSIONS: Aortic valve replacement with either the autograft or allograft provides good clinical results in children and young adults during an intermediate duration of observation. Survival early after ARR does not differ depending on the type of prosthesis. In patients with aortic valve disease, autograft and allograft ARR show comparable satisfactory early and long-term results, with the increasing reoperation risk in the second decade after operation remaining a major concern.


Subject(s)
Aortic Valve Insufficiency/surgery , Aortic Valve Stenosis/surgery , Aortic Valve/transplantation , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Retrospective Studies , Young Adult
9.
J Thorac Cardiovasc Surg ; 143(3): 543-9, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22340029

ABSTRACT

BACKGROUND: Standard cryopreserved valved allografts (SCAs) are recognized as the benchmark for reconstruction of the right ventricular outflow tract (RVOT). However, SCAs frequently demonstrate early valve deterioration and elicit an immune response. Decellularized cryopreserved valve allografts (SynerGraft, SG) are less immunogenetic and may be more durable. This study analyzed our results of RVOT reconstruction using SGs and compared it with the SCAs used during the same period. METHODS: We reviewed the outcome of all allografts (SG and SCA) that were implanted for RVOT reconstruction at a single center from 2000 to 2005. Echocardiographic data were reviewed to evaluate valve performance. Conduit failure is defined as the need for conduit replacement or reintervention in either the catheterization laboratory or operating room. Conduit dysfunction is defined as RVOT obstruction with peak echocardiographic Doppler gradient greater than 40 mm Hg and/or grade III/IV or greater conduit valve regurgitation. Data were compared using the Wilcoxon rank sum and Fisher's exact test. RESULTS: From January 2000 to April 2005, 100 patients (mean age 18.6 ± 16.8 years) received SG (n = 39) or SCA (n = 61) conduits. The 2 retrospective nonrandomized cohorts were similar with respect to age, gender, weight, conduit indication, bypass and crossclamp time, and conduit size. Follow-up time was not significant between the 2 groups (SG, 5.7 ± 2.5 years vs SCA, 5.8 ± 2.8 years; P = .83). Early and late mortality were similar (SG, 13%; SCA, 10%; P = .75). No death was graft related. Freedom from dysfunction was superior with SG (SG, 74%, vs SCA, 52%; P = .05). Freedom from failure was also better in patients with SG (SG, 87%, vs SCA, 68%; P = .05). Freedom from explantation and more than moderate pulmonary insufficiency were significantly better for SG patients (SG, 92% and 90%, vs SCA, 78% and 68%; P = .02). CONCLUSIONS: This study suggests that the midterm performance of SGs may be superior to that of SCAs. Decellularization of the cryopreserved allografts may provide a more durable option for patients who need RVOT reconstruction. Further long-term follow-up is needed to see whether this decellularization process improves long-term allograft durability.


Subject(s)
Bioprosthesis , Cryopreservation , Heart Defects, Congenital/surgery , Heart Valve Prosthesis Implantation/instrumentation , Heart Valve Prosthesis , Adolescent , Adult , Aged , Chi-Square Distribution , Child , Child, Preschool , Echocardiography, Doppler , Female , Heart Defects, Congenital/diagnostic imaging , Heart Defects, Congenital/mortality , Heart Valve Prosthesis Implantation/adverse effects , Heart Valve Prosthesis Implantation/mortality , Hospital Mortality , Humans , Illinois , Kaplan-Meier Estimate , Male , Middle Aged , Postoperative Complications/etiology , Postoperative Complications/surgery , Prosthesis Design , Prosthesis Failure , Reoperation , Retrospective Studies , Risk Assessment , Risk Factors , Time Factors , Transplantation, Homologous , Treatment Outcome , Young Adult
10.
Pediatr Crit Care Med ; 9(4): 393-7, 2008 Jul.
Article in English | MEDLINE | ID: mdl-18496398

ABSTRACT

OBJECTIVE: Children's digits are often too small for proper attachment of oximeter sensors, necessitating sensor placement on the sole of the foot or palm of the hand. No study has determined what effect these sensor locations have on the accuracy and precision of this technology. The objective of this study was to assess the effect of sensor location on pulse oximeter accuracy (i.e., bias) and precision in critically ill children. DESIGN: Prospective, observational study with consecutive sampling. SETTING: Tertiary care, pediatric intensive care unit. PATIENTS: Fifty critically ill children, newborn to 2 yrs of age, with an indwelling arterial catheter. Forty-seven of 50 (94%) patients were postcardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Co-oximeter-measured arterial oxygen saturation (Sao2) was compared with simultaneously obtained pulse oximetry saturations (Spo2). A total of 98 measurements were obtained, 48 measurements in the upper extremities (finger and palm) and 50 measurements in the lower extremities (toe and sole). The median Sao2 was 92% (66% to 100%). There was a significant difference in bias (i.e., average Spo2 - Sao2) and precision (+/-1 sd) when the sole and toe were compared (sole, 2.9 +/- 3.9 vs. toe, 1.6 +/- 2.2, p = .02) but no significant difference in bias and precision between the palm and the finger (palm, 1.4 +/- 3.2 vs. finger, 1.2 +/- 2.3, p = .99). There was a significant difference in bias +/- precision when the Sao2 was <90% compared with when Sao2 was >or=90% in the sole (6.0 +/- 5.7 vs. 1.8 +/- 2.1, p = .002) and palm (4.5 +/- 4.5 vs. 0.7 +/- 2.4, p = .006) but no significant difference in the finger (1.8 +/- 3.8 vs. 1.1 +/- 1.8, p = .95) or toe (1.9 +/- 2.9 vs. 1.6 +/- 1.9, p = .65). CONCLUSIONS: The Philips M1020A pulse oximeter and Nellcor MAX-N sensors were less accurate and precise when used on the sole of the foot or palm of the hand of a child with an Sao2 <90%.


Subject(s)
Cyanosis/diagnosis , Oximetry/methods , Child, Preschool , Critical Illness , Foot , Hand , Humans , Infant , Infant, Newborn , Intensive Care Units, Pediatric , Prospective Studies
11.
J Extra Corpor Technol ; 39(3): 168-76, 2007 Sep.
Article in English | MEDLINE | ID: mdl-17972451

ABSTRACT

Techniques for pediatric cardiac surgery requiring cardiopulmonary bypass (CPB) have significantly improved over the years. The use of fresh whole blood (FWB) and pre-bypass ultrafiltration (PBUF) has been suggested as means for improving perioperative and postoperative outcomes. It is the intent of this study to show that fresh whole blood along with PBUF will result in balanced CPB prime that can offer a reduction in blood product exposures and blood loss along with improving several measured postoperative outcomes. After institutional review board approval, a retrospective review was conducted on 100 patients to analyze the benefits of FWB and PBUF on outcomes in neonatal and pediatric cardiac surgery. Data analysis included preoperative and CPB data, perioperative inotrope and blood product exposure, and postoperative blood loss and blood product exposure measured for up to a 12-hour period in the intensive care unit (ICU). The three groups compared were FWB prime vs. packed red blood cell (PRBC) prime, < 5 kg FWB prime vs. < 5 kg PRBC prime, and 5+ kg FWB prime and 5+ kg PRBC prime. Cumulative blood product exposures for the FWB prime group found 62% received one blood exposure for the operative and postoperative period (p < .0001). The majority of patients who received a PRBC prime (64%) received three or more cumulative exposures (p < .0003). The < 5 kg FWB group also received significantly less cumulative blood exposure, with 64% receiving just one exposure. Comparatively, 85% of the < 5 kg PRBC patients received three or more blood product exposures perioperatively and postoperatively (p < .0001). Perioperative inotrope and postoperative blood loss did not differ among the groups. Outcomes for intraoperative death, intraoperative extubation, delayed sternal closure, and mediastinal reexploration were also not statistically different. The results of this study found that FWB leads to significantly less blood exposure, specifically in the < 5-kg population. Finally, the use of PBUF is an effective method for achieving a balanced, physiologic prime. Future research would be helpful in determining which specific patient populations would receive the greatest benefit from FWB and PBUF.


Subject(s)
Blood Transfusion/methods , Cardiopulmonary Bypass/statistics & numerical data , Cardiovascular Surgical Procedures/statistics & numerical data , Plasma , Postoperative Complications/epidemiology , Child , Child, Preschool , Comorbidity , Female , Humans , Infant , Infant, Newborn , Male , Nebraska/epidemiology , Outcome Assessment, Health Care , Treatment Outcome
12.
J Intensive Care Med ; 19(4): 229-34, 2004.
Article in English | MEDLINE | ID: mdl-15296623

ABSTRACT

The objective of this prospective, observational study with consecutive sampling was to assess the reliability, bias, and precision of Nellcor N-395 (N) and Masimo SET Radical (M) pulse oximeters in children with cyanotic congenital heart disease and children with congenital heart disease recovering from cardiopulmonary bypass-assisted surgery admitted to a cardiovascular operating suite and pediatric intensive care unit at a tertiary care community hospital. Forty-six children with congenital heart disease were studied in 1 of 2 groups: (1) those recovering from cardiopulmonary bypass with a serum lactic acid > 2 mmol/L, and (2) those with co-oximetry measured saturations (SaO(2)) < 90% and no evidence of shock. Measurements of SaO(2) of whole blood were compared to simultaneous pulse oximetry saturations (SpO(2)). Data were analyzed to detect significant differences in SpO(2) readout failures between oximeters and average SpO(2) - SaO(2) +/- 1 SD for each oximeter. A total of 122 SaO(2) measurements were recorded; the median SaO(2) was 83% (57 - 100%). SpO(2) failures after cardiopulmonary bypass were 41% (25/61) for N versus 10% (6/61) for M (P < .001). There was a significant difference in bias (ie, average SpO(2) - SaO(2)) and precision (+/- 1 SD) between oximeters (N, 1.1 +/- 3.3 vs M, -0.2 +/- 4.1; P < .001) in the postcardiopulmonary bypass group but no significant difference in bias and precision between oximeters in the cyanotic congenital heart disease group (N, 2.9 +/- 4.6 vs M, 2.8 +/- 6.2; P = .848). The Nellcor N-395 pulse oximeter failed more often immediately after cardiopulmonary bypass than did the Masimo SET Radical pulse oximeter. SpO2 measured with both oximeters overestimated SaO2 in the presence of persistent hypoxemia.


Subject(s)
Cardiopulmonary Bypass , Cyanosis/blood , Heart Defects, Congenital/blood , Heart Defects, Congenital/surgery , Oximetry/instrumentation , Cyanosis/etiology , Heart Defects, Congenital/complications , Humans , Infant , Infant, Newborn , Oxygen/blood , Postoperative Period , Predictive Value of Tests , Prospective Studies , Reproducibility of Results
13.
J Extra Corpor Technol ; 35(3): 196-9, 2003 Sep.
Article in English | MEDLINE | ID: mdl-14653419

ABSTRACT

Pediatric patients who have preoperative hemodynamic instability or postoperative cardiac decompensation may frequently require the use of extracorporeal membrane oxygenation (ECMO) for stabilization of cardiac and respiratory function. While ECMO can be a therapeutic treatment for the congenital pediatric patient, it does not allow the additional functions of a complete cardiopulmonary bypass (CPB) circuit should subsequent surgical revision in the operating room be required. This paper will discuss our approach to converting the ECMO circuit to total cardiopulmonary bypass allowing the use of cardioplegia, cardiotomy suction, and modified ultrafiltration. This technique allows the conversion to CPB without ceasing support to the critically ill patient or exposing them to additional blood products or surface area in the priming of a new extracorporeal circuit. In addition, this circuit design allows for the resumption of ECMO support utilizing the same circuit if the patient necessitates it.


Subject(s)
Coronary Artery Bypass/methods , Extracorporeal Membrane Oxygenation/methods , Heart Defects, Congenital/surgery , Child , Coronary Artery Bypass/instrumentation , Extracorporeal Membrane Oxygenation/instrumentation , Humans , Illinois , Pediatrics/instrumentation
14.
J Pediatr Surg ; 37(10): 1399-403, 2002 Oct.
Article in English | MEDLINE | ID: mdl-12378442

ABSTRACT

BACKGROUND/PURPOSE: Hospital mortality rate among children with hypoplastic left heart syndrome (HLHS) after cardiac repair is well documented, but comparable data after noncardiac, surgical procedures are unknown. The authors hypothesized an increasing number of noncardiac procedures were being performed on children with HLHS, less than 2 years of age, from 1988 to 1997, and that these procedures were associated with a substantial mortality rate. METHODS: A retrospective review of hospital discharge data for 2,457 children less than 2 years of age with HLHS for 1988 through 1997 was performed. The authors examined the outcomes of HLHS children undergoing only noncardiac surgical procedures during their hospital stay. Differences in hospital mortality rates between 1988 through 1992 versus 1993 through 1997 were assessed using the Chi2 square statistic. RESULTS: Nineteen percent of the 147 children with HLHS undergoing noncardiac, surgical procedures died (95% CI, 13% to 25%). Comparing the 2 study periods, there was no significant change in outcome among HLHS children undergoing noncardiac, surgical procedures (78% v. 83%; P >.1). There was no significant difference in the percentage of hospital discharges with noncardiac, surgical procedures performed per year. CONCLUSIONS: Although children with HLHS were not undergoing an increase in the number of noncardiac surgical procedures performed annually, even minor surgical procedures were associated with considerable mortality. Outcomes after noncardiac surgery in high-risk children with congenital heart disease warrant further investigation.


Subject(s)
Hypoplastic Left Heart Syndrome/complications , Surgical Procedures, Operative/mortality , Cardiac Surgical Procedures/mortality , Hospital Mortality , Hospitalization/statistics & numerical data , Humans , Hypoplastic Left Heart Syndrome/epidemiology , Infant , Infant Mortality , Logistic Models , Odds Ratio , Patient Discharge/statistics & numerical data , Retrospective Studies , Risk Factors , Treatment Outcome , United States/epidemiology
15.
Ann Thorac Surg ; 73(2): 655-7, 2002 Feb.
Article in English | MEDLINE | ID: mdl-11845897

ABSTRACT

A 13-year-old Haitian girl presented with complex congenital heart disease consisting of transposition of the great arteries with total anomalous venous return. The patient exhibited clinical findings of long-standing congestive heart failure and cyanosis. She underwent complete repair with resolution of her symptoms.


Subject(s)
Pulmonary Veins/abnormalities , Transposition of Great Vessels/surgery , Adolescent , Blood Vessel Prosthesis Implantation , Brachiocephalic Veins/abnormalities , Brachiocephalic Veins/surgery , Chronic Disease , Female , Heart Failure/diagnosis , Heart Failure/surgery , Humans , Hypoplastic Left Heart Syndrome/diagnosis , Hypoplastic Left Heart Syndrome/surgery , Pulmonary Veins/surgery , Reoperation , Transposition of Great Vessels/diagnosis , Tricuspid Valve Insufficiency/congenital , Tricuspid Valve Insufficiency/diagnosis , Tricuspid Valve Insufficiency/surgery
16.
Article in English | MEDLINE | ID: mdl-11486229

ABSTRACT

Allograft valves have been used in cardiac valve replacement for over 40 years. Early failures of allograft mitral valve replacement (AMVR) were attributed to inadequate allograft preservation or unsuccessful implantation techniques. Due to an improved understanding of mitral valve function gained from experience in mitral valve reconstruction, improved imaging techniques for preoperative assessment, and improved methods of allograft preservation, there has been a resurgence of interest in AMVR. The use of bioprosthetic valves in children and young adults is characterized by reduced durability and early valve failure. With the use of mechanical valves, there is a significant long-term risk of morbidity and mortality resulting from thrombosis or hemorrhagic complications from anticoagulation. Additionally, anticoagulation is often difficult to manage in children. The advantages of using allograft mitral valves include the avoidance of anticoagulation and the preservation of the subvalvar apparatus and its role in ventricular function. At our institution, successful early results with AMVR have been obtained in eight children and young adults with previous atrioventricular septal defects, previous placement of mitral valve prostheses, rheumatic valvular disease, and bacterial endocarditis. Our early results and those of others are encouraging for the continued use of AMVR in children and young adults. Long-term follow-up will be necessary to assess the durability and function of these allograft mitral valves. Copyright 1999 by W.B. Saunders Company

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