ABSTRACT
The histopathologic characteristics of the decidual reaction in the uterus of aging mice and the "mesenchymal lesion/tumor" in the urinary bladder of aging mice are compared and found to be very similar. Both lesions consist of spindle and epithelioid cells, may contain round eosinophilic granules and possess nuclear progesterone receptors and cytoplasmic desmin. The decidual reaction derives from endometrial stromal cells, while the "mesenchymal lesion" apparently develops from mesenchymal cells near the trigone area, carrying or developing progesterone receptors. If the hypothesis is accepted that in aging mice the uterine decidual reaction and the "mesenchymal lesion" in the urinary bladder represent an equivalent type of tissue reaction, then it follows that the typical "mesenchymal lesion" is not a tumor and could be called more specifically "decidual-like reaction".
Subject(s)
Aging/pathology , Decidua/pathology , Mesenchymoma/pathology , Urinary Bladder Neoplasms/pathology , Animals , Cell Nucleus/metabolism , Cell Nucleus/pathology , Cytoplasmic Granules/metabolism , Cytoplasmic Granules/pathology , Decidua/metabolism , Desmin/metabolism , Female , Immunoenzyme Techniques , Male , Mice , Mice, Inbred C57BL , Precancerous Conditions/metabolism , Precancerous Conditions/pathology , Receptors, Progesterone/metabolismSubject(s)
Carnivora , Chromogranins/metabolism , Glucagon/metabolism , Insulin/metabolism , Pancreatic Neoplasms/veterinary , Animals , Animals, Zoo , Cats , Chromogranins/analysis , Female , Glucagon/analysis , Immunohistochemistry , Insulin/analysis , Microscopy, Electron/veterinary , Pancreas/chemistry , Pancreas/metabolism , Pancreas/pathology , Pancreatic Neoplasms/chemistry , Pancreatic Neoplasms/metabolism , Somatostatin/analysis , Somatostatin/metabolismSubject(s)
Islets of Langerhans/cytology , Pancreas/cytology , Swine , Animals , Female , Male , Orchiectomy , Species SpecificityABSTRACT
Borna disease virus (BDV) infection, naturally occurring in horses and sheep induces a mononuclear retinitis and meningoencephalitis in adult Lewis rats. In the pathogenesis a virus-specific cell mediated immune reaction presumably of delayed hypersensitivity type is operative. Corresponding to the encephalitic lesions a progressive retinitis with loss of the first and second retinal neuron develops. The inflammatory response is characterized by predominance of macrophages in the early phase of infection followed by distinct plasmacellular infiltration. Immunosuppressed and immuno-incompetent rats do not develop retinal lesions after intracerebral inoculation. Thus similar as in the brain probably virus specific immunopathological reactions play a crucial role in the pathogenesis of BDV-induced retinitis in Lewis rats.
Subject(s)
Borna Disease/immunology , Retinitis/immunology , Animals , Antigens, Viral/immunology , Axons/immunology , Borna Disease/pathology , Borna disease virus/immunology , Brain/microbiology , Injections, Intraventricular , Rats , Rats, Inbred Lew , Retinitis/pathology , Virus ReplicationABSTRACT
This report describes a highly fatal diphtheroid-necrotizing stomatitis in tortoises of hitherto unknown etiology. The tortoises suffered from dyspnea and anorexia, due to massive diphtheroid membranes in oral and pharyngeal cavities. Histologically, eosinophilic intranuclear inclusion bodies were found in epithelial layers of oral and tracheal mucous membranes. Furthermore, electron microscopy revealed herpesvirus like particles in affected cells. Possible environmental factors influencing the outbreak of the disease are discussed.
Subject(s)
Herpesviridae Infections/veterinary , Stomatitis/veterinary , Turtles , Animals , Anorexia/veterinary , Dyspnea/veterinary , Epithelium/pathology , Herpesviridae/ultrastructure , Herpesviridae Infections/pathology , Microscopy, Electron , Mouth Mucosa/pathology , Stomatitis/pathology , Trachea/pathologyABSTRACT
A thoroughbred horse, suffering from intermittent lameness was treated with streptokinase, urokinase and warfarin. The appearing fibrinolytic changes in coagulation were exhibited in a resonance thrombogram. In attendant coagulation studies fibrinogen- and fibrin-degradation products were demonstrated. The stallion does not show any lameness since the end of the treatment and is standing in a breeding station since March 1988.