ABSTRACT
Neutrophilic diseases may have various clinical presentations but share common histopathological manifestations with an aseptic infiltrate of polymorphonuclears neutrophils. The association with various diseases is frequent and must be systematically discussed. We report a patient who presented three different synchronous clinical manifestations of neutrophilic disease: pyoderma gangrenosum, subcorneal pustular dermatosis and aseptic spleen abscesses.
Subject(s)
Abscess/etiology , Neutrophils , Pyoderma Gangrenosum/etiology , Skin Diseases, Vesiculobullous/etiology , Splenic Diseases/etiology , Aged, 80 and over , Humans , Male , Pyoderma Gangrenosum/complications , Skin Diseases, Vesiculobullous/complications , Splenic Diseases/complicationsABSTRACT
Chronic cavitary pulmonary aspergillosis requires a first-line prolonged treatment with itraconazole or voriconazole. We report a 71-year-old immunocompetent man with polyarteritis and history of multiple lung surgery procedures, who developed a peripheral axonal neuropathy 1 month after voriconazole therapy was started for a chronic cavitary pulmonary aspergillosis. After discontinuation of the treatment and a switch to posaconazole, the neuropathy partly improved. Three other cases of peripheral neuropathy with voriconazole have been already published, all reversible after voriconazole discontinuation.
Subject(s)
Antifungal Agents/adverse effects , Aspergillosis, Allergic Bronchopulmonary/drug therapy , Peripheral Nervous System Diseases/chemically induced , Pyrimidines/adverse effects , Triazoles/adverse effects , Triazoles/therapeutic use , Aged , Antifungal Agents/therapeutic use , Chronic Disease , Humans , Male , Pain/chemically induced , Pain/physiopathology , Peripheral Nervous System Diseases/physiopathology , Pyrimidines/therapeutic use , Treatment Outcome , VoriconazoleABSTRACT
Panton-Valentine leukocidin-producing (PVL) Staphylococcus aureus is responsible for a highly lethal necrotizing pneumonia, which occurs predominantly in young immunocompetent patients. Hemoptysis and leucopenia often occur but are not always present. Detection of PVL gene on S. aureus strains responsible for pneumonia should help us to a better understanding of this disease, to improve its treatment with antibiotics capable of lower the toxin production and to prevent its diffusion to others persons by detection and elimination of a nasal S. aureus carriage.
