Epithelial ovarian cancer in female pseudohermaphroditism. A diagnosis by computed tomography and review of the literature.

We describe the case of a patient proven to be a female pseudohermaphrodite with a complete virilization syndrome who developed an epithelial tumor of the ovary of borderline malignancy. The tumor appeared as an abdominal mass with cystic features on ultrasonography. The diagnosis of the intersexual condition and adnexal cancer was made by computed tomography (CT).

Correlation between pretreatment prognostic factors and lymph node metastases in endometrial adenocarcinoma. Clinical application.

PURPOSE: To evaluate the prognosis of stage I endometrial adenocarcinoma, which differs by various prognostic factors. Some of them (tumor grading, histotype, myometrial infiltration, the latter evaluated with Magnetic Resonance Imaging) can be assessed before surgery. These prognostic factors correlate with patient survival and the presence of lymph node metastases. MATERIAL AND METHODS: We used tumor grading, histotype, myometrial infiltration for the preoperative and prospective classification into a low- and a high-risk group of 80 patients with endometrial adenocarcinomas stage I. Low-risk patient [group A: G1-G2, pure adenocarcinoma involving the inner portion of the myometrium (M0-M1)] underwent surgery without lymph node resection, while high-risk patients [group B: G3, pure adenocarcinoma with deep infiltration of the myometrium (M2) and/or clear cell, serous papillary, adenosquamous carcinomas] had pelvic and lumboaortic lymphadenectomy. The minimum 36 months' follow-up (median: 61 months) was requested for all patients. RESULTS: Histotype evaluated by dilatation and curettage and hysteroscopic and/or office biopsy, had 100% agreement with tumor histotype. Tumor grading was in agreement in 72/80 patients (81%). The grade of myometrial infiltration was confirmed in 72/80 cases (81%). Eight misdiagnoses were divided in over--(4 cases) and under--(4 cases) estimated infiltration. All 16 mistakes resulted in 10 inclusion in the wrong risk group (8 in the low-risk and two in the high-risk group). Surgical-pathological staging did not change the prognosis but only staging in 6 preoperatively high-risk group. CONCLUSIONS: This initial study confirms the importance of prognostic factors in the treatment of endometrial adenocarcinoma, as well as that of the different surgical choices which can be made after correct pretreatment prognosis.

Preliminary studies on the fetal cord blood as a means for the early detection of metabolic defects: I. plasma proteins

The possibility of using fetal cord blood in the early detection of genetic/metabolic defects in Filipino was studied by an initial establishment of baseline values. Total proteins were determined from 57 sample sets (a set is made of maternal blood sample and corresponding fetal cord blood). All blood samples were also subjected to cellulose acetate electrophoresis. Mcans of total proteins and individual protein fractions. (L1, L2, B2 globulins) of mothers were significantly higher (p=0.05) than the means of their corresponding newborns. Level of maternal total proteins L1, L2, B2 globulin fractions were lineary related to those of their corresponding new borns. However fetal cord albumins was not significantly diferent from maternal levels nor where they lineary related. Factors such as age of mothers, gravidity and age of gestation did not affect the concentration of fetal total proteins, and the different protein fractions. With the exception of the L2 globulins, the levels of total proteins and other protein fractions in the male neonates. Birth weights affected the levels of total proteins, L2 B2 globulin fractions in the neonates. (Auth)