Angiotensin ii therapy in refractory septic shock: which patient can benefit most? A narrative review.

Patients with septic shock who experience refractory hypotension despite adequate fluid resuscitation and high-dose noradrenaline have high mortality rates. To improve outcomes, evidence-based guidelines recommend starting a second vasopressor, such as vasopressin, if noradrenaline doses exceed 0.5 µg/kg/min. Recently, promising results have been observed in treating refractory hypotension with angiotensin II, which has been shown to increase mean arterial pressure and has been associated with improved outcomes. This narrative review aims to provide an overview of the pathophysiology of the renin-angiotensin system and the role of endogenous angiotensin II in vasodilatory shock with a focus on how angiotensin II treatment impacts clinical outcomes and on identifying the population that may benefit most from its use.

Analysis of the Scenarios of Use of an Innovative Technology for the Fast and Nondestructive Characterization of Viscoelastic Materials in the Tires Field.

The properties of tires related to their viscoelastic behavior have a significant impact in the field of vehicle dynamics. They affect the performance and safety of a vehicle based on how they change when the tire performs in variable thermal conditions, interacts with various kinds of road surfaces, and accumulates mileage over time. To analyze and understand such properties of viscoelastic materials, destructive tests like dynamic mechanical analysis (DMA) are used, which make the tire unusable after the test; these are usually carried out on specimens cut from the zone of interest. The development of an innovative testing methodology connected to a hardware device called VESevo allows the characterization of the viscoelastic properties of tire compounds belonging to tread or other parts in a fast and nondestructive way. This new device provides valuable information about the evolution of the tire's viscoelastic properties, allowing it to monitor them throughout the whole lifecycle. In the paper, an overview of the possible sensitivities that can be investigated thanks to the VESevo is provided: The tread viscoelasticity was characterized and monitored for several tire tread compounds, over tire mileage, over tread thermal curing cycles, and as an index of the tread quality and uniformity in production. Preliminary results were collected and are presented. In the final paragraph, further recent applications developed from the tire field, which are not directly related, are reported.

Estimation of Vehicle Longitudinal Velocity with Artificial Neural Network.

Vehicle dynamics control systems have a fundamental role in smart and autonomous mobility, where one of the most crucial aspects is the vehicle body velocity estimation. In this paper, the problem of a correct evaluation of the vehicle longitudinal velocity for dynamic control applications is approached using a neural networks technique employing a set of measured samples referring to signals usually available on-board, such as longitudinal and lateral acceleration, steering angle, yaw rate and linear wheel speed. Experiments were run on four professional driving circuits with very different characteristics, and the vehicle longitudinal velocity was estimated with different neural network training policies and validated through comparison with the measurements of the one acquired at the vehicle's center of gravity, provided by an optical Correvit sensor, which serves as the reference (and, therefore, exact) velocity values. The results obtained with the proposed methodology are in good agreement with the reference values in almost all tested conditions, covering both the linear and the nonlinear behavior of the car, proving that artificial neural networks can be efficiently employed onboard, thereby enriching the standard set of control and safety-related electronics.

Fractional Calculus Approach to Reproduce Material Viscoelastic Behavior, including the Time-Temperature Superposition Phenomenon.

The design of modern products and processes cannot prescind from the usage of viscoelastic materials that provide extreme design freedoms at relatively low cost. Correct and reliable modeling of these materials allows effective use that involves the design, maintenance, and monitoring phase and the possibility of reuse and recycling. Fractional models are becoming more and more popular in the reproduction of viscoelastic phenomena because of their capability to describe the behavior of such materials using a limited number of parameters with an acceptable accuracy over a vast range of excitation frequencies. A particularly reliable model parametrization procedure, using the poles-zeros formulation, allows researchers to considerably reduce the computational cost of the calibration process and avoid convergence issues typically occurring for rheological models. The aim of the presented work is to demonstrate that the poles-zeros identification methodology can be employed not only to identify the viscoelastic master curves but also the material parameters characterizing the time-temperature superposition phenomenon. The proposed technique, starting from the data concerning the isothermal experimental curves, makes use of the fractional derivative generalized model to reconstruct the master curves in the frequency domain and correctly identify the coefficients of the WLF function. To validate the methodology, three different viscoelastic materials have been employed, highlighting the potential of the material parameters' global identification. Furthermore, the paper points out a further possibility to employ only a limited number of the experimental curves to feed the identification methodology and predict the complete viscoelastic material behavior.

Measuring the environmental sustainability performance of global supply chains: A multi-regional input-output analysis for carbon, sulphur oxide and water footprints.

Measuring the performance of environmentally sustainable supply chains instead of chain constitute has become a challenge despite the convergence of the underlining principles of sustainable supply chain management. This challenge is exacerbated by the fact that supply chains are inherently dynamic and complex and also because multiple measures can be used to characterize performances. By identifying some of the critical issues in the literature regarding performance measurements, this paper contributes to the existing body of literature by adopting an environmental performance measurement approach for economic sectors. It uses economic sectors and evaluates them on a sectoral level in specific countries as well as part of the Global Value Chain based on the established multi-regional input-output (MRIO) modeling framework. The MRIO model has been used to calculate direct and indirect (that is supply chain or upstream) environmental effects such as CO2, SO2, biodiversity, water consumption and pollution to name just a few of the applications. In this paper we use MRIO analysis to calculate emissions and resource consumption intensities and footprints, direct and indirect impacts, and net emission flows between countries. These are exemplified by using carbon emissions, sulphur oxide emissions and water use in two highly polluting industries; Electricity production and Chemical industry in 33 countries, including the EU-27, Brazil, India and China, the USA, Canada and Japan from 1995 to 2009. Some of the highlights include: On average, direct carbon emissions in the electricity sector across all 27 member states of the EU was estimated to be 1368 million tons and indirect carbon emissions to be 470.7 million tons per year representing 25.6% of the EU-27 total carbon emissions related to this sector. It was also observed that from 2004, sulphur oxide emissions intensities in electricity production in India and China have remained relatively constant at about 62.8 gSOx/, respectively, $ and 84.4 gSOx/$ although being higher than in other countries. In terms of water use, the high water use intensity in China (1040.27 L/$) and India (961.63 L/$), which are among the highest in the sector in the electricity sector is exacerbated by both countries being ranked as High Water Stress Risk countries. The paper also highlights many advantages of the MRIO approach including: a 15-year time series study (which provides a measurement of environmental performance of key industries and an opportunity to assess technical and technological change during the investigated time period), a supply chain approach that provides a consistent methodological framework and accounts for all upstream supply chain environmental impacts throughout entire global supply chains. The paper also discusses the implications of the study to environmental sustainability performance measurement in terms of the level of analysis from a value chain hierarchy perspective, methodological issues, performance indicators, environmental exchanges and policy relevance.