Subject(s)
Arthritis, Reactive/microbiology , Clostridioides difficile , HLA-B27 Antigen/immunology , Adult , Anti-Bacterial Agents/adverse effects , Anti-Bacterial Agents/therapeutic use , Anti-Inflammatory Agents, Non-Steroidal/therapeutic use , Arthritis, Reactive/drug therapy , Diarrhea/drug therapy , Enterocolitis, Pseudomembranous/chemically induced , Humans , Italy , MaleABSTRACT
The authors take as their starting point the cases of 8 pregnancies in HIV serologically positive women, admitted for their observation from July 1986 to March 1988. They emphasize the importance of clinical, anamnestic and serological screening in order to identify those subjects at risk, and thereby prevent the vertical transmission of the virus. To this end, they propose a protocol to be used for all women at risk, both pregnant and not, both seropositive and seronegative. They also advise repeated clinical and immunological checks of the children of asymptomatic carrier mothers.
Subject(s)
Acquired Immunodeficiency Syndrome/diagnosis , HIV Seropositivity/diagnosis , HIV/immunology , Pregnancy Complications, Infectious/diagnosis , AIDS Serodiagnosis/methods , Adolescent , Adult , Enzyme-Linked Immunosorbent Assay , Female , Follow-Up Studies , HIV Antibodies/analysis , Humans , Infant, Newborn , Pregnancy , Risk FactorsABSTRACT
An indirect immunofluorescence staining technique was employed to evaluate the TQ1 and 5/9 monoclonal antibody lymphocyte reactivity in 10 cord blood mononuclear cell (MC) preparations enriched of E-rosette-forming cells (E+). Ten adult E+ MC populations were used as controls. Unfractionated T4+ cord and adult MC positively selected by panning procedure were also assayed. The results of these experiments, taken together, suggest that there is an overexpanded neonatal T cell subset which displays a previously unrecognized immunophenotype (T4+, TQ1+, 5/9+). Whether these lymphocytes are involved in the wellknown fetal-maternal immunosuppressive mechanisms of whether they are a further example of neonatal phenotypic immaturity remains to be elucidated.
