ABSTRACT
OBJECTIVE: To investigate the relationship of strictures of the common bile duct (CBD) with pain in patients with chronic pancreatitis (CP) and jaundice. METHODS: A total of 61 patients with CBD strictures caused by CP of alcoholic etiology were treated by endoscopic stent insertion for 1 year with scheduled stent exchanges. Pain was assessed using a visual analogue scale, and analgesic medication was recorded prior to and after endoscopic treatment. RESULTS: Endoscopic drainage was successful in all cases, with complete resolution of jaundice during the 1-year follow-up period. Prior to the endoscopic stent insertion, pain scores were 6.8 +/- 6.3. Following stent therapy pain scores were 7.7 +/- 7.7. Pain scores, the number of patients requiring analgesics, the required amount of analgesics, and the type of analgesic medication did not change following treatment of CBD stricture. CONCLUSION: Successful endoscopic drainage of biliary obstruction has no influence on pain pattern in patients with CP. CBD obstruction does not cause pain in patients with CP.
Subject(s)
Abdominal Pain/etiology , Common Bile Duct Diseases/complications , Pancreatitis/complications , Abdominal Pain/diagnosis , Adult , Aged , Chronic Disease , Common Bile Duct Diseases/surgery , Constriction, Pathologic/complications , Constriction, Pathologic/surgery , Female , Follow-Up Studies , Humans , Jaundice, Obstructive/etiology , Male , Middle Aged , Stents/adverse effects , Treatment OutcomeABSTRACT
A diffusion cell type which is suitable for investigation of water-insoluble compounds is shown. The chamber consists of two compartments, the so-called bottom-chamber, which contains the solid substance under investigation, and the main chamber, which is above it. In this chamber only the dissolved part of the substance is present. The solubility of dibenzylsulfide was determined and it was demonstrated that the dissolved part of this compound is accumulated by a receptor substance from the liquid phase.
Subject(s)
Benzyl Compounds/metabolism , Cell Membrane Permeability , Diffusion , Equipment and Supplies , Models, Biological , Solubility , WaterABSTRACT
Dibenzylsulfid (DBS) as a model of the organic sulfur compounds in crude oil was converted by a mixed culture (containing Pseudomonas aeruginosa) into several water soluble organic substances. Whereas these compounds are detectable with DC- and IR-spectroscopic techniques, benzylmercaptoacetic acid (BMA) was the only isolated product of DBS utilization. Efficiency of degradation, respectively, accumulation of BMA were dependent on aeration and pH-regulation.
