[Features of diagnosis and treatment of fatty pancreatic necrosis]. / Osobennosti diagnostiki i lecheniia zhirovogo pankreonekroza.

The article deals with clinical experience in early diagnosis of pancreatonecrosis in which enzymological methods of examination acquire importance. The most informative test in the diagnosis of fatty pancreatonecrosis is the increase of the pancreatic lipase content in blood serum, particularly in stimulation of pancreatic secretion by pancreozymin. A new Soviet-produced peptide agent--dalargin was included in the complex drug treatment of fatty pancreatonecrosis in 74 patients. With the use of dalargin as an inhibitor of the activity of pancreatic enzymes and kinins in the treatment of fatty pancreatonecrosis a marked positive effect was produced. The mortality in fatty pancreatonecrosis was 5.5%.

[Treatment of non-healing wounds and trophic ulcers by low- intensity laser irradiation in an outpatient clinic]. / Lechenie dlitel'no ne zazhivaiushchikh ran i troficheskikh iazv nizkointensivnym lazernym izlucheniem v usloviiakh polikliniki.

Experience in treating 351 patients with persistent wounds and trophic ulcers by low-intensity laser radiation in out-patient clinics is generalized. Complete epithelialization of the wound or ulcer surface occurred in 236 patients. There were 246 patients aged 60, all were treated without leave from work. Thus, the inclusion of laser therapy in the complex of measures for persistent wounds and trophic ulcers is a highly effective method which may be applied in preoperative management and which will reduce considerably the term of in-patient treatment.

[Treatment of peptic ulcer hemorrhage with leucine enkephalin analog dalargin]. / Lechenie iazvennykh gastroduodenal'nykh krovotechenii s primeneniem analoga leitsin--enkefalina-dalargina.

The article discusses treatment of 72 patients suffering from duodenal ulcer complicated by bleeding with the Soviet-made preparation Dalargin which is a synthetic analogue of leucine-enkephalin. The preparation was infused intravenously in a dose of 3 mg in physiological solution once daily. No other additional antiulcerative agents were give. The diagnosis was established on the basis of endoscopy. Dalargin led to cicatrization of the ulcers in 20.3 days in 60% of patient, obvious positive dynamics was noted in 32% of patients; in 8% of patients Dalargin proved ineffective. Basal hydrochloric acid secretion reduced by 56% during treatment.

[Plasmapheresis in the treatment of critical stages of ischemia in diabetic angiopathy of the lower extremities]. / Plazmaferez v lechenii kriticheskikh stepenei ishemii pri diabeticheskoi angiopatii nizhnikh konechnostei.

The authors have used gravitation plasmapheresis in the treatment of 26 patients with diabetic angiopathies of lower extremities. It was established that continuous gravitation plasmapheresis facilitated the immediate correction of most of the altered biochemical and coagulation parameters of blood, in patients with diabetes mellitus. The use of rheopolyglucinum is followed by stable central hemodynamics and stabilization of the general state of the patients during continuous plasmapheresis which allows to recommend rheopolyglucinum as the main plasma-substituting solution for fractionation of blood in patients with diabetic angiopathies. The gravitation plasmapheresis used in the treatment of critical degrees of ischemia in patients with diabetic angiopathies of lower extremities is thought by the authors to allow to preserve the extremity or to make the level of its amputation lower in most patients.

[Epidural-sacral anesthesia in radical surgical treatment of acute paraproctitis]. / Epidural'no-sakral'naia anesteziia pri radikal'nom khirurgicheskom lechenii ostrogo paraproktita.

The epidural-sacral anesthesia was used in 242 patients operated upon for different forms of acute paraproctitis. No complications resulting from the anesthesia were noted. The incidence of failures in performing epidural-sacral anesthesia was 3.6%. The epidural-sacral anesthesia has advantages over other kinds of anesthesia, is safe and not technically difficult and practically has no contraindications.

[Comparative evaluation of the effect of kontrikal, 5-fluorouracil and the new Soviet peptide preparation dalargin on the course of experimental pancreonecrosis]. / Sravnitel'naia otsenka vliianiia kontrikala, 5-ftoruratsila i novogo otechestvennogo peptidnogo preparata dalargina na techenie éksperimental'nogo pankreonekroza.

The experiments on 24 dogs with experimental hemorrhagic pancreonecrosis showed that contrykal and 5-fluorouracil insignificantly decrease the area of the damaged parenchyma, fail to cease progression of the pancreas destruction. The peptide drug dalargin in these conditions increased the antitryptic activity and normalized BAEE esterase activity. Dalargin abolished erythrostasis and microthromboses in the vessels of the microcirculation, restored the blood supply throughout the area of the exocrine parenchyma, limited necrotic foci and suspended the development of pancreonecrosis.

[Surgical treatment of acute paraproctitis]. / Khirurgicheskoe lechenie ostrogo paraproktita.

The authors made operations on 113 patients with various forms of acute periproctitis by their original method. One of its main elements was to open the intermuscular space of the rectum by dissection of the internal sphincter and part of the circular muscular layer. The proposed method of treatment of acute periproctitis is thought by the authors to be radical since the operation was not followed by recidivations which shortened staying of the patients at the hospital.

[Effect of an analog of endogenous opioids, dalargin, on the structure and function of the exocrine tissue of the pancreas in experimental acute pancreatitis]. / Vliianie analoga endogennykh opioidov dalargina na strukturu i funktsiiu ekzokrinnoi tkani podzheludochnoi zhelezy pri eksperimental'nom ostrom pankreatite.

The paper is concerned with the inhibitory effect of dalargia, a new analogue of leu-enkephalin synthesized at the Laboratory of Peptides, All-Union Cardiology Research Center, Academy of Medical Sciences of the USSR. Acute experiments on 22 dogs were performed to examine the effect of parenteral administration of dalargin in the total dose 3 mg on morphological and functional changes in the endocrine tissue of the pancreas. It was shown that intravenous injection of dalargin reduces the basal secretion and inhibits the synthesis of pancreatic enzymes in animals with the intact pancreas. In progressive hemorrhagic pancreonecrosis, intravenous drip of dalargin improves the microhemocirculation and recovers the blood supply of the pancreatic parenchyma, restricts the foci of necrosis, reduces the involvement into the pathological process of unaffected exocrine cells. Comparative analysis of changes in enzymological characteristics in the course of pancreonecrosis development before and after parenteral administration of dalargin has revealed a reduction in the proteolytic and kininogenase activity, normalization of the antitryptic activity of the pancreas.

[Removal of residual calculi of the bile ducts]. / Udalenie rezidual'nykh kamnei zhelchnykh protokov.

Residual gall-stones were removed from the common bile duct in 11 patients. The removal was carried out through fistulous passage or by pushing the gall-stones into the duodenum.