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Bioorg Med Chem Lett ; 17(21): 5928-33, 2007 Nov 01.
Article in English | MEDLINE | ID: mdl-17869100

ABSTRACT

A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole 9q exhibits good oral bioavailability in rats and dogs as well as efficacy following an oral 10 mg/kg dose in dogs. Solution and solid phase protocols for the synthesis of tetrazole based GHS have been developed.


Subject(s)
Growth Hormone/metabolism , Tetrazoles/chemistry , Tetrazoles/pharmacology , Animals , Dogs , Structure-Activity Relationship , Tetrazoles/chemical synthesis
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