ABSTRACT
Hemostasis was studied in 373 oilmen aged 20-40 working according to expedition schedules. Control subjects were not engaged in expeditions. Expedition labor was found to cause hypercoagulemia with parallel decline in anticoagulant activity. Vascular wall ability to release anticoagulants and fibrinolysis activators in the blood stream appeared inhibited. Platelet count in the peripheral blood, platelet aggregation, platelet factor III activity were increased. The duration of expedition service and phases of working cycle seem to affect hemostatic parameters.
Subject(s)
Blood Coagulation Disorders/blood , Blood Platelets/physiology , Endothelium, Vascular/physiology , Fibrinolysis/physiology , Occupational Diseases/blood , Adult , Blood Coagulation Disorders/etiology , Humans , MaleSubject(s)
Hemorrhage/chemically induced , Insulin/pharmacology , Thrombosis/chemically induced , Animals , Blood Coagulation/drug effects , Blood Platelets/drug effects , Female , Fibrinolysis/drug effects , Hemorrhage/physiopathology , Male , Rabbits , Syndrome , Thrombosis/physiopathology , Time FactorsSubject(s)
Burns/blood , Heparin/blood , Adolescent , Adult , Aged , Blood Coagulation Disorders/blood , Female , Humans , Male , Middle Aged , Shock, Traumatic/bloodABSTRACT
In 36 rabbits the role of the heart in the genesis of changes in the tissue components of blood clotting and fibrinolysis in thyroxine toxicosis was studied. It was found that on the 5th and 10th days of toxicosis the thromboplastic (P = 0.002) an anticoagulant (P less than 0.001) myocardial activities decreased, and on the 15th day, increased. On the 20th day the myocardial thromboplastic activity remained increased, whereas the anticoagulant activity was further sinking (P = 0.05). Simultaneously the total fibrinolytic activity in the blood flowing through the heart and in myocardial extract increased (P less than 0.001), and the antiplasmin activity decreased.