ABSTRACT
- Intra-articular injections have been in use for over 60 years. However, there is increasing awareness of potential side effects associated with the intra- and peri-articular use of both glucocorticoids and topical analgesics.- In this review we will discuss the effects and side effects of intra-articular glucocorticoid injections in the context of non-rheumatic knee and shoulder conditions. Other commonly used indications for glucocorticoid use are also described.- For almost all indications, intra-articular glucocorticoid injections provide a small and short-term pain-suppressing effect. Long-term therapeutic effects do not exist.- Side effects range from local skin problems to adrenocortical suppression which can persist for weeks.- Glucocorticoid injections may be indicated in daily practice but have no long-term effect. In view of the potential (harmful) side effects, it is advisable to use the lowest possible effective dose.