ABSTRACT
A carencia de vitamina C interfere tanto na atividade da enzima lecitina colesterol acil-transferase como na transformacao do colesterol em seu principal catabolico: os acidos biliares. Tem-se observado ainda, a presenca de varicosidade da veia sublingual em individuos com hipovitaminose C. Selecionamos quinze pacientes com niveis sanguineos de colesterol normais e quinze pacientes hipercolesterolemicos para estudar a correlacao entre a hipercolesterolemia e a deficiencia de ingestao de vitamina C. Realizamos analise estatistica com teste "t" de Student e teste tipo Caso-Controle, obtendo os seguintes dados: (1) Quanto ao nivel de colesterol, os dois grupos apresentaram diferenca significativa, no grupo hipercolesterolemicos com niveis de 422 ñ 116,2018 mg/100 ml e no grupo normocolesterolemicos 160,73 ñ 29,5356 mg/100 ml. (2) A media diaria de vitamina C na dieta e significativamente maior no grupo normocolesterolemico (170,33 ñ 75,18 mg) do que no grupo hipercolesterolemico (39,01 ñ 25,89 mg). (3) O grupo hipercolesterolemico apresenta uma media de ingestao diaria maior do colesterol do que o grupo normocolesterolemico, porem nao ha significancia estatistica. (4) O grupo hipercolesterolemico demonstra a ocorrencia maior de varicosidade sublingual estatisticamente significante em treze casos enquanto que no...
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Ascorbic Acid Deficiency/complications , Hypercholesterolemia/metabolism , Ascorbic Acid/pharmacology , Ascorbic Acid/therapeutic use , Cholesterol/blood , Cholesterol/metabolism , Ascorbic Acid Deficiency/metabolism , Hypercholesterolemia/drug therapy , Hypercholesterolemia/etiologyABSTRACT
The deficiency of ascorbic acid in the diet affects the activity of lecithin cholesterol acyl-transferase enzyme and transformation of cholesterol to its main catabolic product the biliary acids. Fifteen patients with normal blood levels of cholesterol and fifteen patients with hypercholesterolemia were submitted to a comparative study as to the dietary ingestion of ascorbic acid. Besides this the presence of the varicosity of the sublingual vein--indicating hypovitaminosis C--was investigated in both groups of patients. The "t" Student test and Control-Case test of the results showed that regarding the cholesterol level there was a significant difference between the patients with hypercholesterolemia (422 +/- 116.2018 mg/100 ml) and those with normal cholesterolemia (160.73 +/- 29.5356 mg/100 ml). The ingestion of ascorbic acid in he diet of the normal cholesterolemia group was found to be significantly higher than that of patients with hypercholesterolemia. The ingestion of cholesterol was high in the group of patients with hypercholesterolemia but in comparison with other groups there was no significant difference. The varicosity of the sublingual vein was observed with significantly higher frequency (p < 0.0001) in the group of patients with hypercholesterolemia and lower ingestion of ascorbic acid.
