ABSTRACT
56 patients at the age of 18-60 years with severe trauma were examined. Influence of the polyelectrolytic (Reamberin)solution on an acid-base state, osmolarity and electrolytic composition of plasma in the acute posttraumatic period was evaluated. It was found that patients, who was treated by isotonic sodium chloride solution and Ringer's solution, had metabolic acidosis and hyperchloremia. In contrast, in the reamberin group 82% of patients had lower concentrations of chloride and had nothing acid-base disturbances on the second day after trauma. Reamberin didn't influence on plasma osmolarity and the rate of metabolic alkalosis during the acute period of a trauma.
Subject(s)
Acidosis/drug therapy , Fluid Therapy/methods , Meglumine/analogs & derivatives , Multiple Trauma/drug therapy , Succinates/therapeutic use , Acid-Base Equilibrium/drug effects , Acidosis/etiology , Adolescent , Adult , Chlorine/blood , Erythrocyte Transfusion , Female , Humans , Isotonic Solutions , Male , Meglumine/administration & dosage , Meglumine/therapeutic use , Middle Aged , Multiple Trauma/blood , Multiple Trauma/complications , Multiple Trauma/metabolism , Ringer's Solution , Succinates/administration & dosage , Trauma Severity Indices , Treatment Outcome , Young AdultABSTRACT
Diminution of reperfusion and re-oxygenation lesions is an important task in the treatment of patients with severe injury and blood loss. From this standpoint the influence of perforan on the condition of the oxidant-antioxidant system was studied in patients with severe combined trauma. The application of perftoran in the early post-trauma period was found to intensify the processes of lipid peroxidation and, simultaneously, to normalize the parameters of the antioxidant-protection system.
Subject(s)
Fluorocarbons/therapeutic use , Hemorrhage/metabolism , Lipid Peroxidation/drug effects , Multiple Trauma/metabolism , APACHE , Adult , Ceruloplasmin/metabolism , Colloids/administration & dosage , Crystalloid Solutions , Erythrocyte Transfusion , Female , Fluorocarbons/administration & dosage , Hemorrhage/complications , Hemorrhage/therapy , Humans , Infusions, Parenteral , Isotonic Solutions , Lactoferrin/blood , Male , Malondialdehyde/blood , Multiple Trauma/complications , Multiple Trauma/therapy , Plasma Exchange , Plasma Substitutes/administration & dosage , Trauma Severity Indices , Treatment OutcomeABSTRACT
Relationship between alteration of body position and parameters of central hemodynamics and oxygen status were studied in patients with severe blunt chest injury. Use of position tests in this patient population helped detect disorders in the central hemodynamics, oxygen transport and consumption. Argument increase of volumetric loading promoted an increase in oxygen delivery.
