ABSTRACT
The effect of topical dapiprazole, an alpha-adrenergic receptor blocker, in reversing mydriasis was studied in 50 subjects who received tropicamide 1% and phenylephrine 2.5%. There was a significant difference in the decrease in pupil size between the eye that received dapiprazole and the control eye. This study suggests that dapiprazole 0.5% eye drops are effective and safe in reversing mydriasis after instillation of tropicamide 1% and phenylephrine 2.5%.
Subject(s)
Adrenergic alpha-Antagonists/pharmacology , Phenylephrine/antagonists & inhibitors , Pupil/drug effects , Pyridines/antagonists & inhibitors , Triazoles/pharmacology , Tropicamide/antagonists & inhibitors , Adolescent , Adult , Aged , Blood Pressure/drug effects , Female , Heart Rate/drug effects , Humans , Intraocular Pressure/drug effects , Male , Middle Aged , Piperazines , Visual Acuity/drug effectsABSTRACT
A prospective randomized clinical trial was carried out to determine the efficacy of 6-hydroxybenzo[b]thiophene-2-sulfonamide, a potent new carbonic anhydrase inhibitor, in lowering intraocular pressure (IOP) in normotensive volunteers. The drug was administered as a 2% suspension twice daily for 1 week to one eye in 10 subjects. Ten other subjects, serving as controls, received a placebo drop to one eye on the same schedule. Subjects and examiners were unaware of whether the drug or placebo was being used. IOP was measured before the study began and twice daily on days 1, 2, 4 and 8 of the study. The drug had no significant effect on IOP. The most likely explanation is failure of an adequate concentration of the drug to reach the ciliary body.
