Comparing pre-hospital clinical diagnosis of pediatric out-of-hospital cardiac arrest with etiology by coroner's diagnosis.

OBJECTIVES: Making an accurate clinical diagnosis in the field can be a great challenge with pediatric out-of-hospital cardiac arrest (OHCA). We aimed to compare the etiology of pediatric OHCA by pre-hospital clinical diagnosis with etiology by coroner's diagnosis and autopsy. DESIGN: As part of the Ontario Pre-hospital Advanced Life Support (OPALS) study, we conducted a prospective cohort study including children below age 19 with OHCA during an 11-year period. Prehospital clinical diagnosis was determined by blinded review and deaths were then matched with provincial coroner's office records. The agreement between prehospital clinical diagnosis and autopsy diagnosis was derived by consensus review. Inter-observer agreement was evaluated using kappa values. RESULTS: For the period 1992-2002, there were 414 cardiac arrests in children <19 years of age that matched coroner's records. Mean age was 5.9 years (S.D. 6.4 years) with 39.4% of cases under 1 year of age. Etiology by clinical diagnosis was medical 49.5%, trauma 36.0% and undetermined 14.5%. The overall kappa for clinical diagnosis compared to coroner's diagnosis was 0.62. The kappa for medical cases was 0.53, trauma was 0.93 and 'undetermined' was -0.01. Medical clinical diagnosis had a lower agreement with the coroner's diagnosis (62.4%) compared with trauma (96.0%), RR 0.65, 95% CI [0.58, 0.73]. The poorest kappas by diagnosis were for neurological (0.39), respiratory (0.42), 'other' medical (0.56), SIDS (0.58) and cardiac (0.63). The commonest coroner's diagnoses in the 'undetermined' clinical diagnosis category were: pneumonia (17.6%), seizure or post-seizure (11.8%), arrhythmia (9.8%) and aspiration (5.9%). CONCLUSION: Even in an ideal situation, a clinician in the field might be unable to determine the etiology of pediatric cardiac arrest in 14.5% of cases. There is poorer agreement for 'medical' compared to 'trauma' cases. This is the largest study to date comparing clinical diagnosis of the causes of OHCA in children to the 'gold-standard' of coroner's diagnosis.

Etiology of pediatric out-of-hospital cardiac arrest by coroner's diagnosis.

OBJECTIVES: To determine etiology of pediatric OHCA in a population-based sample from autopsy and coroner's diagnosis. DESIGN: As part of the Ontario Pre-hospital Advanced Life Support (OPALS) study, we conducted a prospective cohort study including children below age 19 years with OHCA in an 11-year period. Deaths were matched with provincial coroner's office records and autopsies and investigation notes were reviewed. RESULTS: From 1992 to 2002, there were 474 cardiac arrests in children below 19 years of age giving an annual incidence of 59.7 per million children. Mean age was 5.8 (S.D. 6.3), 43.0% were <1 year of age, males were 59.1%. 25.1% were bystander witnessed and 20.3% received bystander CPR. 1.9% survived to discharge. Four hundred and thirty nine matched to coroner's office records. Annual incidence rates per million by age groups were: 175.0 (age 1-4 years), 33.0 (age 5-14 years) and 61.6 (age 15-18). Annual incidence rates per million according to coroner's cause of death were: natural (26.2), accidental (17.4), suicide (3.7) and homicide (1.9). Post-mortem rate was 84.3% and Mean Injury Severity Score was 31.4 (S.D. 16.5). The commonest causes of natural death were SIDS (30.3%), cardiovascular (19.2) and respiratory (18.3%). The commonest causes of accidental death were drowning (27.5%), residential accidents (18.8%), fire (13.0%) and motor vehicle collisions (12.3%). CONCLUSION: The highest mortality rates were among children age <4 years. 52.6% of deaths were from 'unnatural' causes (accidental, suicide, homicide, undetermined). Our findings will be useful for planning prevention, treatment and future research of pediatric OHCA.