[Effectiveness of immunodiagnosis of drug intolerance in adolescents having tuberculosis and concomitant diseases]. / Effektivnost' immunodiagnostiki lekarstvennoí neperenosimosti u podrostkov, bol'nykh tuberkulezom i imeiushchikh soputstvuiushchie zabolevaniia.

Fifty seven adolescents having tuberculosis and clinical signs of drug intolerance were examined by immunological tests (thermistometry and blast-transformation reaction in 20 and 37 patients, respectively). Of them 30 patients had concomitant diseases. Patients with concurrent abnormalities require laboratory evidence for drug intolerance. Of all negative tests, they were more common in patients with concomitant abnormalities (65.5%), but they amounted to 34.5% in those without concomitant abnormalities. There was a similarity of the clinical symptomatology of intolerance with negative immunological responses to the exacerbation or increased symptoms of concomitant diseases.

[Use of monoclonal antibodies for immunodiagnosis of lung cancer]. / Ispl'zovanie monoklonal'nykh antitel dlia immunodiagnostiki raka legkikh.

Fifty-three patients with lung cancer of different histological types and 72 with other lung diseases were examined by employing the panel containing 5 monoclonal antibodies (MAb) in the indirect immunofluorescence test (IFT). with tissue biopsy specimens, lung cancer could be revealed in 100% of patients with glandular carcinomas and adenocarcinoma of the lung, in 89% of those with small-cell carcinoma, and in 61% with squamous-cell carcinoma. With this, MAb reacted with cancer cellular membranes, by causing their fluorescence and failed to react and to cause the luminescence of inflammation cell membranes, the altered and intact bronchoalveolar epithelium in patients cancer and nontumoral diseases of the lung. IFT with MAb to lung cancerous surface antigens with the cells of tissue biopsy specimens may be a supplementation to cytological studies.

[Use of data bank on tuberculosis patients and of computer program for clinical and immunological analysis]. / Ispol'zovanie banka dannykh o bol'nykh tuberkulezom i komp'iuternoí programmy dlia kliniko-immunologicheskogo analiza.

Three hundred and twenty patients with pulmonary tuberculosis were clinically and immunologically compared. The findings support the significance and prospects for using a personal computer while making clinical and laboratory comparisons in different groups of patients for a prompt and objective analysis of available data. Comparative evaluation of the informative value of immunologic tests have indicated that in relation to the major clinical parameters of a tuberculous process, differences are great in those characterizing both T- and B-cell, and specific antimycobacterial immunity. The clinical and immunological findings regarding the specific features of a tuberculosis process may serve as the basis for multidimensional analysis and development of criteria for computer-aided clinical and immunological diagnosis of tuberculosis.

[Progress and prospects of tuberculosis immunology and immunogenetics]. / Dostizheniia i perspectivy issledovanii v oblasti immunologii i immunogenetiki tuberkuleza.

Reviews the recent progress in immunopathogenesis, immunogenetics, immunodiagnosis, immunotherapy, and immunoprophylaxis of tuberculosis. The findings of Russian scientists (primarily at the Central Research Institute of Tuberculosis, Russian Academy of Medical Sciences) are compatible to the results of medical centers abroad.