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1.
Dev Psychopathol ; 35(3): 1382-1389, 2023 08.
Article in English | MEDLINE | ID: mdl-34924093

ABSTRACT

Altered autobiographical memory (ABM) processing characterizes some individuals with experiences of childhood maltreatment. This fMRI study of ABM processing evaluated potential developmental plasticity in neural functioning following maltreatment. Adolescents with (N = 19; MT group) and without (N = 18; Non-MT group) documented childhood maltreatment recalled specific ABMs in response to emotionally valenced cue words during fMRI at baseline (age 12.71 ± 1.48) and follow-up (14.88 ± 1.53 years). Psychological assessments were collected at both timepoints. Longitudinal analyses were carried out with BOLD signal changes during ABM recall and psychopathology to investigate change over time. In both groups there was relative stability of the ABM brain network, with some developmental maturational changes observed in cortical midline structures (ventromedial PFC (vmPFC), posterior cingulate cortex (pCC), and retrosplenial cortex (rSC). Significantly increased activation of the right rSC was observed only in the MT group, which was associated with improved psychological functioning. Baseline group differences in relation to hippocampal functioning, were not detected at follow-up. This study provides preliminary empirical evidence of functional developmental plasticity in children with documented maltreatment experience using fMRI. This suggests that altered patterns of brain function, associated with maltreatment experience, are not fixed and may reflect the potential to track a neural basis of resilience.


Subject(s)
Magnetic Resonance Imaging , Memory, Episodic , Adolescent , Child , Humans , Brain/diagnostic imaging , Brain/physiology , Mental Recall/physiology , Neuronal Plasticity
2.
Astron Astrophys ; 6372020 May.
Article in English | MEDLINE | ID: mdl-32565548

ABSTRACT

CONTEXT: Sulphur is one of the most abundant elements in the Universe. Surprisingly, sulphuretted molecules are not as abundant as expected in the interstellar medium and the identity of the main sulphur reservoir is still an open question. AIMS: Our goal is to investigate the H2S chemistry in dark clouds, as this stable molecule is a potential sulphur reservoir. METHODS: Using millimeter observations of CS, SO, H2S, and their isotopologues, we determine the physical conditions and H2S abundances along the cores TMC 1-C, TMC 1-CP, and Barnard 1b. The gas-grain model Nautilus is used to model the sulphur chemistry and explore the impact of photo-desorption and chemical desorption on the H2S abundance. RESULTS: Our modeling shows that chemical desorption is the main source of gas-phase H2S in dark cores. The measured H2S abundance can only be fitted if we assume that the chemical desorption rate decreases by more than a factor of 10 when n H > 2 × 104. This change in the desorption rate is consistent with the formation of thick H2O and CO ice mantles on grain surfaces. The observed SO and H2S abundances are in good agreement with our predictions adopting an undepleted value of the sulphur abundance. However, the CS abundance is overestimated by a factor of 5 - 10. Along the three cores, atomic S is predicted to be the main sulphur reservoir. CONCLUSIONS: The gaseous H2S abundance is well reproduced, assuming undepleted sulphur abundance and chemical desorption as the main source of H2S. The behavior of the observed H2S abundance suggests a changing desorption efficiency, which would probe the snowline in these cold cores. Our model, however, highly overestimates the observed gas-phase CS abundance. Given the uncertainty in the sulphur chemistry, we can only conclude that our data are consistent with a cosmic elemental S abundance with an uncertainty of a factor of 10.

3.
Astron Astrophys ; 6282019 Aug.
Article in English | MEDLINE | ID: mdl-31511745

ABSTRACT

CONTEXT: Sulphur is one of the most abundant elements in the Universe (S/H∼1.3×10 -5 ) and plays a crucial role in biological systems on Earth. The understanding of its chemistry is therefore of major importance. AIMS: Our goal is to complete the inventory of S-bearing molecules and their abundances in the prototypical photodissociation region (PDR) the Horsehead nebula to gain insight into sulphur chemistry in UV irradiated regions. Based on the WHISPER (Wide-band High-resolution Iram-30m Surveys at two positions with Emir Receivers) millimeter (mm) line survey, our goal is to provide an improved and more accurate description of sulphur species and their abundances towards the core and PDR positions in the Horsehead. METHODS: The Monte Carlo Markov Chain (MCMC) methodology and the molecular excitation and radiative transfer code RADEX were used to explore the parameter space and determine physical conditions and beam-averaged molecular abundances. RESULTS: A total of 13 S-bearing species (CS, SO, SO2, OCS, H2CS - both ortho and para - HDCS, C2S, HCS+, SO+, H2S, S2H, NS and NS+) have been detected in the two targeted positions. This is the first detection of SO+ in the Horsehead and the first detection of NS+ in any PDR. We find a differentiated chemical behaviour between C-S and O-S bearing species within the nebula. The C-S bearing species C2S and o-H2CS present fractional abundances a factor of > two higher in the core than in the PDR. In contrast, the O-S bearing molecules SO, SO2, and OCS present similar abundances towards both positions. A few molecules, SO+, NS, and NS+, are more abundant towards the PDR than towards the core, and could be considered as PDR tracers. CONCLUSIONS: This is the first complete study of S-bearing species towards a PDR. Our study shows that CS, SO, and H2S are the most abundant S-bearing molecules in the PDR with abundances of ∼ a few 10-9. We recall that SH, SH+, S, and S+ are not observable at the wavelengths covered by the WHISPER survey. At the spatial scale of our observations, the total abundance of S atoms locked in the detected species is < 10-8, only ∼0.1% of the cosmic sulphur abundance.

4.
Astron Astrophys ; 6242019 May 17.
Article in English | MEDLINE | ID: mdl-31156252

ABSTRACT

GEMS is an IRAM 30m Large Program whose aim is determining the elemental depletions and the ionization fraction in a set of prototypical star-forming regions. This paper presents the first results from the prototypical dark cloud TMC 1. Extensive millimeter observations have been carried out with the IRAM 30m telescope (3 mm and 2 mm) and the 40m Yebes telescope (1.3 cm and 7 mm) to determine the fractional abundances of CO, HCO+, HCN, CS, SO, HCS+, and N2H+ in three cuts which intersect the dense filament at the well-known positions TMC 1-CP, TMC 1-NH3, and TMC 1-C, covering a visual extinction range from A V ~ 3 to ~20 mag. Two phases with differentiated chemistry can be distinguished: i) the translucent envelope with molecular hydrogen densities of 1-5×103 cm-3; and ii) the dense phase, located at A V > 10 mag, with molecular hydrogen densities >104 cm-3. Observations and modeling show that the gas phase abundances of C and O progressively decrease along the C+/C/CO transition zone (A V ~ 3 mag) where C/H ~ 8×10-5 and C/O~0.8-1, until the beginning of the dense phase at A V ~ 10 mag. This is consistent with the grain temperatures being below the CO evaporation temperature in this region. In the case of sulfur, a strong depletion should occur before the translucent phase where we estimate a S/H ~ (0.4 - 2.2) ×10-6, an abundance ~7-40 times lower than the solar value. A second strong depletion must be present during the formation of the thick icy mantles to achieve the values of S/H measured in the dense cold cores (S/H ~8×10-8). Based on our chemical modeling, we constrain the value of ζ H2 to ~ (0.5 - 1.8) ×10-16 s-1 in the translucent cloud.

7.
Astron Astrophys ; 6152018 Jul.
Article in English | MEDLINE | ID: mdl-30185990

ABSTRACT

CONTEXT: In bright photodissociation regions (PDRs) associated to massive star formation, the presence of dense "clumps" that are immersed in a less dense interclump medium is often proposed to explain the difficulty of models to account for the observed gas emission in high-excitation lines. AIMS: We aim at presenting a comprehensive view of the modeling of the CO rotational ladder in PDRs, including the high-J lines that trace warm molecular gas at PDR interfaces. METHODS: We observed the 12CO and 13CO ladders in two prototypical PDRs, the Orion Bar and NGC 7023 NW using the instruments onboard Herschel. We also considered line emission from key species in the gas cooling of PDRs (C+, O, H2) and other tracers of PDR edges such as OH and CH+. All the intensities are collected from Herschel observations, the literature and the Spitzer archive and are analyzed using the Meudon PDR code. RESULTS: A grid of models was run to explore the parameter space of only two parameters: thermal gas pressure and a global scaling factor that corrects for approximations in the assumed geometry. We conclude that the emission in the high-J CO lines, which were observed up to J up =23 in the Orion Bar (J up =19 in NGC 7023), can only originate from small structures of typical thickness of a few 10-3 pc and at high thermal pressures (Pth ~ 108 K cm-3). CONCLUSIONS: Compiling data from the literature, we found that the gas thermal pressure increases with the intensity of the UV radiation field given by G0, following a trend in line with recent simulations of the photoevaporation of illuminated edges of molecular clouds. This relation can help rationalising the analysis of high-J CO emission in massive star formation and provides an observational constraint for models that study stellar feedback on molecular clouds.

8.
Astron Astrophys ; 6162018 Aug.
Article in English | MEDLINE | ID: mdl-31844332

ABSTRACT

The properties of molecular gas, the fuel that forms stars, inside the cavity of the circumnuclear disk (CND) are not well constrained. We present results of a velocity-resolved submillimeter scan (~480 to 1250 GHz) and [C ii] 158 µm line observations carried out with Herschel/HIFI toward Sgr A*; these results are complemented by a ~2'×2' 12CO (J=3-2) map taken with the IRAM 30 m telescope at ~7″ resolution. We report the presence of high positive-velocity emission (up to about +300 km s-1) detected in the wings of 12CO J=5-4 to 10-9 lines. This wing component is also seen in H2O (11,0-10,1), a tracer of hot molecular gas; in [C ii]158 µm, an unambiguous tracer of UV radiation; but not in [C i] 492, 806 GHz. This first measurement of the high-velocity 12CO rotational ladder toward Sgr A* adds more evidence that hot molecular gas exists inside the cavity of the CND, relatively close to the supermassive black hole (< 1 pc). Observed by ALMA, this velocity range appears as a collection of 12CO (J=3-2) cloudlets lying in a very harsh environment that is pervaded by intense UV radiation fields, shocks, and affected by strong gravitational shears. We constrain the physical conditions of the high positive-velocity CO gas component by comparing with non-LTE excitation and radiative transfer models. We infer T k≃400 K to 2000 K for n H≃(0.2-1.0)·105 cm-3. These results point toward the important role of stellar UV radiation, but we show that radiative heating alone cannot explain the excitation of this ~10-60 M ⊙ component of hot molecular gas inside the central cavity. Instead, strongly irradiated shocks are promising candidates.

9.
Astron Astrophys ; 6202018 Dec.
Article in English | MEDLINE | ID: mdl-31844333

ABSTRACT

The Barnard 1b core shows signatures of being at the earliest stages of low-mass star formation, with two extremely young and deeply embedded protostellar objects. Hence, this core is an ideal target to study the structure and chemistry of the first objects formed in the collapse of prestellar cores. We present ALMA Band 6 spectral line observations at ~0.6″ of angular resolution towards Barnard 1b. We have extracted the spectra towards both protostars, and used a Local Thermodynamic Equilibrium (LTE) model to reproduce the observed line profiles. B1b-S shows rich and complex spectra, with emission from high energy transitions of complex molecules, such as CH3OCOH and CH3CHO, including vibrational level transitions. We have tentatively detected for the first time in this source emission from NH2CN, NH2CHO, CH3CH2OH, CH2OHCHO, CH3CH2OCOH and both aGg' and gGg' conformers of (CH2OH)2. This is the first detection of ethyl formate (CH3CH2OCOH) towards a low-mass star forming region. On the other hand, the spectra of the FHSC candidate B1b-N are free of COMs emission. In order to fit the observed line profiles in B1b-S, we used a source model with two components: an inner hot and compact component (200 K, 0.35″) and an outer and colder one (60 K, 0.6″). The resulting COM abundances in B1b-S range from 10-13 for NH2CN and NH2CHO, up to 10-9 for CH3OCOH. Our ALMA Band 6 observations reveal the presence of a compact and hot component in B1b-S, with moderate abundances of complex organics. These results indicate that a hot corino is being formed in this very young Class 0 source.

10.
Astron Astrophys ; 6062017 Oct.
Article in English | MEDLINE | ID: mdl-29142329

ABSTRACT

AIMS: The formation epoch of protostellar disks is debated because of the competing roles of rotation, turbulence, and magnetic fields in the early stages of low-mass star formation. Magnetohydrodynamics simulations of collapsing cores predict that rotationally supported disks may form in strongly magnetized cores through ambipolar diffusion or misalignment between the rotation axis and the magnetic field orientation. Detailed studies of individual sources are needed to cross check the theoretical predictions. METHODS: We present 0.06 - 0.1 ″ resolution images at 350 GHz toward B1b-N and B1b-S, which are young class 0 protostars, possibly first hydrostatic cores. The images have been obtained with ALMA, and we compare these data with magnetohydrodynamics simulations of a collapsing turbulent and magnetized core. RESULTS: The submillimeter continuum emission is spatially resolved by ALMA. Compact structures with optically thick 350 GHz emission are detected toward both B1b-N and B1b-S, with 0.2 and 0.35″ radii (46 and 80 au at the Perseus distance of 230 pc), within a more extended envelope. The flux ratio between the compact structure and the envelope is lower in B1b-N than in B1b-S, in agreement with its earlier evolutionary status. The size and orientation of the compact structure are consistent with 0.2″ resolution 32 GHz observations obtained with the Very Large Array as a part of the VANDAM survey, suggesting that grains have grown through coagulation. The morphology, temperature, and densities of the compact structures are consistent with those of disks formed in numerical simulations of collapsing cores. Moreover, the properties of B1b-N are consistent with those of a very young protostar, possibly a first hydrostatic core. These observations provide support for the early formation of disks around low-mass protostars.

11.
Astron Astrophys ; 6062017 Oct.
Article in English | MEDLINE | ID: mdl-29093600

ABSTRACT

The extremely young Class 0 object B1b-S and the first hydrostatic core (FSHC) candidate, B1b-N, provide a unique opportunity to study the chemical changes produced in the elusive transition from the prestellar core to the protostellar phase. We present 40"×70" images of Barnard 1b in the 13CO 1→0, C18O 1→0, NH2D 11,1a→10,1s, and SO 32→21 lines obtained with the NOEMA interferometer. The observed chemical segregation allows us to unveil the physical structure of this young protostellar system down to scales of ∼500 au. The two protostellar objects are embedded in an elongated condensation, with a velocity gradient of ∼0.2-0.4 m s-1 au-1 in the east-west direction, reminiscent of an axial collapse. The NH2D data reveal cold and dense pseudo-disks (R∼500-1000 au) around each protostar. Moreover, we observe evidence of pseudo-disk rotation around B1b-S. We do not see any signature of the bipolar outflows associated with B1b-N and B1b-S, which were previously detected in H2CO and CH3OH, in any of the imaged species. The non-detection of SO constrains the SO/CH3OH abundance ratio in the high-velocity gas.

12.
Astron Astrophys ; 5992017 Mar.
Article in English | MEDLINE | ID: mdl-28260804

ABSTRACT

CONTEXT: The methylidyne cation (CH+) and hydroxyl (OH) are key molecules in the warm interstellar chemistry, but their formation and excitation mechanisms are not well understood. Their abundance and excitation are predicted to be enhanced by the presence of vibrationally excited H2 or hot gas (~500-1000 K) in photodissociation regions with high incident FUV radiation field. The excitation may also originate in dense gas (> 105 cm-3) followed by nonreactive collisions with H2, H, and electrons. Previous observations of the Orion Bar suggest that the rotationally excited CH+ and OH correlate with the excited CO, a tracer of dense and warm gas, and formation pumping contributes to CH+ excitation. AIMS: Our goal is to examine the spatial distribution of the rotationally excited CH+ and OH emission lines in the Orion Bar in order to establish their physical origin and main formation and excitation mechanisms. METHODS: We present spatially sampled maps of the CH+ J=3-2 transition at 119.8 µm and the OH Λ-doublet at 84 µm in the Orion Bar over an area of 110″×110″ with Herschel (PACS). We compare the spatial distribution of these molecules with those of their chemical precursors, C+, O and H2, and tracers of warm and dense gas (high-J CO). We assess the spatial variation of CH+ J=2-1 velocity-resolved line profile at 1669 GHz with Herschel HIFI spectrometer observations. RESULTS: The OH and especially CH+ lines correlate well with the high-J CO emission and delineate the warm and dense molecular region at the edge of the Bar. While notably similar, the differences in the CH+ and OH morphologies indicate that CH+ formation and excitation are strongly related to the observed vibrationally excited H2. This, together with the observed broad CH+ line widths, indicates that formation pumping contributes to the excitation of this reactive molecular ion. Interestingly, the peak of the rotationally excited OH 84 µm emission coincides with a bright young object, proplyd 244-440, which shows that OH can be an excellent tracer of UV-irradiated dense gas. CONCLUSIONS: The spatial distribution of CH+ and OH revealed in our maps is consistent with previous modeling studies. Both formation pumping and nonreactive collisions in a UV-irradiated dense gas are important CH+ J=3-2 excitation processes. The excitation of the OH Λ-doublet at 84 µm is mainly sensitive to the temperature and density.

13.
Astron Astrophys ; 5932016 09.
Article in English | MEDLINE | ID: mdl-27708436

ABSTRACT

CONTEXT: Barnard B1b has revealed as one of the most interesting globules from the chemical and dynamical point of view. It presents a rich molecular chemistry characterized by large abundances of deuterated and complex molecules. Furthermore, it hosts an extremely young Class 0 object and one candidate to First Hydrostatic Core (FHSC) proving the youth of this star forming region. AIMS: Our aim is to determine the cosmic ray ionization rate, [Formula: see text], and the depletion factors in this extremely young star forming region. These parameteres determine the dynamical evolution of the core. METHODS: We carried out a spectral survey towards Barnard 1b as part of the IRAM Large program ASAI using the IRAM 30-m telescope at Pico Veleta (Spain). This provided a very complete inventory of neutral and ionic C-, N- and S- bearing species with, up to our knowledge, the first secure detections of the deuterated ions DCS+ and DOCO+. We use a state-of-the-art pseudo-time-dependent gas-phase chemical model that includes the ortho and para forms of [Formula: see text] and [Formula: see text] to determine the local value of the cosmic ray ionization rate and the depletion factors. RESULTS: Our model assumes n(H2)=105 cm-3 and T k =12 K, as derived from our previous works. The observational data are well fitted with ζH2 between 3×10-17 s-1 and 10-16 s-1, and the following elemental abundances: O/H=3 10-5, N/H=6.4-8 10-5, C/H=1.7 10-5 and S/H between 6.0 10-7 and 1.0 10-6. The large number of neutral/protonated species detected, allows us to derive the elemental abundances and cosmic ray ionization rate simultaneously. Elemental depletions are estimated to be ~10 for C and O, ~1 for N and ~25 for S. CONCLUSIONS: Barnard B1b presents similar depletions of C and O than those measured in pre-stellar cores. The depletion of sulfur is higher than that of C and O but not as extreme as in cold cores. In fact, it is similar to the values found in some bipolar outflows, hot cores and photon-dominated regions. Several scenarios are discussed to account for these peculiar abundances. We propose that it is the consequence of the initial conditions (important outflows and enhanced UV fields in the surroundings) and a rapid collapse (~0.1 Myr) that permits to maintain most S- and N-bearing species in gas phase to great optical depths. The interaction of the compact outflow associated with B1b-S with the surrounding material could enhance the abundances of S-bearing molecules, as well.

14.
Astron Astrophys ; 5932016 09 15.
Article in English | MEDLINE | ID: mdl-27721515

ABSTRACT

The CO+ reactive ion is thought to be a tracer of the boundary between a HII region and the hot molecular gas. In this study, we present the spatial distribution of the CO+ rotational emission toward the Mon R2 star-forming region. The CO+ emission presents a clumpy ring-like morphology, arising from a narrow dense layer around the HII region. We compare the CO+ distribution with other species present in photon-dominated regions (PDR), such as [CII] 158 µm, H2 S(3) rotational line at 9.3 µm, polycyclic aromatic hydrocarbons (PAHs) and HCO+. We find that the CO+ emission is spatially coincident with the PAHs and [CII] emission. This confirms that the CO+ emission arises from a narrow dense layer of the HI/H2 interface. We have determined the CO+ fractional abundance, relative to C+ toward three positions. The abundances range from 0.1 to 1.9 ×10-10 and are in good agreement with previous chemical model, which predicts that the production of CO+ in PDRs only occurs in dense regions with high UV fields. The CO+ linewidth is larger than those found in molecular gas tracers, and their central velocity are blue-shifted with respect to the molecular gas velocity. We interpret this as a hint that the CO+ is probing photo-evaporating clump surfaces.

15.
Mycoses ; 59(11): 691-696, 2016 Nov.
Article in English | MEDLINE | ID: mdl-27456474

ABSTRACT

Exophiala spinifera is a dematiaceous fungus responsible for rare skin infections presenting as phaeohyphomycosis or chromoblastomycosis which has been primarily reported in tropical and subtropical areas (Asia, South and North America). We report the first case of E. spinifera phaeohyphomycosis in a European patient. The phaeohyphomycosis was limited to the skin, involving the finger of an immunocompromised patient presenting with a large B-cell lymphoma treated by R-mini-CHOP regimen. Remission was initially achieved by surgical excision; however, a local subcutaneous relapse required treatment with itraconazole. We performed a literature review of the 32 previously published cases of E. spinifera phaeohyphomycosis highlighting its clinical phenotype: disseminated infection with extracutaneous involvement and poor prognosis were reported in young patients, of whom some were recently associated with CARD9 mutations, whereas cases in older immunocompromised patients were limited to the skin and showed better prognosis. There is currently no standard treatment for E. spinifera phaeohyphomycosis; however, itraconazole, alone or in combination, allowed partial or complete response in 16 out of 20 cases.


Subject(s)
Exophiala/isolation & purification , Fingers , Immunocompromised Host , Lymphoma, B-Cell/complications , Phaeohyphomycosis/diagnosis , Phaeohyphomycosis/microbiology , Adult , Aged , Aged, 80 and over , Antifungal Agents/therapeutic use , Child , Child, Preschool , Exophiala/drug effects , Exophiala/ultrastructure , Fingers/surgery , Humans , Itraconazole/therapeutic use , Lymphoma, B-Cell/drug therapy , Lymphoma, B-Cell/microbiology , Male , Middle Aged , Neoplasm Recurrence, Local/microbiology , Phaeohyphomycosis/drug therapy , Skin/microbiology , Skin/pathology , Young Adult
16.
Arch Pediatr ; 23(9): 957-62, 2016 Sep.
Article in English | MEDLINE | ID: mdl-27150561

ABSTRACT

BACKGROUND: Bisphosphonates (BP) are sometimes used in children and young women, but their use requires expertise and caution due to the relative lack of long-term efficacy and safety data. CLINICAL CASES: We report on two dizygotic male twins with a past of mild prematurity who presented at the age of 2 months with moderate clinical craniotabes, hypophosphatemia, normal circulating calcium, severe hypercalciuria, and low parathyroid hormone levels. Following supplementation with oral phosphorus and native vitamin D, the clinical and biological abnormalities disappeared within 2 months. Since the twins were dizygotic and were identical in terms of clinical presentation and progression, the only likely explanation for these transient mineral abnormalities was prenatal or neonatal exposure to a toxic agent. Taking into account their medical past, two drugs were possibly involved: either oral alendronate that their mother had received before pregnancy for misdiagnosed osteoporosis or antireflux medications, or both. DISCUSSION: We believe that these two cases could correspond to the first description of a potential mother-to-fetus transmission of alendronate, inducing early and transient hypophosphatemic rickets, the clinical picture being worsened by the antireflux drugs impairing intestinal phosphate absorption. For pediatric rheumatologists, this raises the question of more clearly defining the indications for BP in female children and teenagers; for rheumatologists, this also demonstrates the importance of correctly diagnosing osteoporosis and not using BP off-label, especially in women of child-bearing age.


Subject(s)
Hypercalciuria/chemically induced , Rickets, Hypophosphatemic/chemically induced , Alendronate/adverse effects , Anti-Ulcer Agents/adverse effects , Bone Density Conservation Agents/adverse effects , Esomeprazole/adverse effects , Female , Humans , Infant , Male , Parathyroid Hormone/blood , Pregnancy , Prenatal Exposure Delayed Effects , Twins, Dizygotic
17.
Rev Med Interne ; 37(6): 429-32, 2016 Jun.
Article in French | MEDLINE | ID: mdl-26427559

ABSTRACT

INTRODUCTION: Among the species of Campylobacter, C. fetus subspecies fetus is characterized by extra-intestinal manifestations, including bloodstream and cardiovascular infections, occurring preferentially in the context of immunosuppression. The cutaneous lesions are rarely described but may be underestimated. CASE REPORTS: We report on 3 cases of cellulitis with bloodstream infection due to Campylobacter fetus subspecies fetus, without cardiovascular infection in a 72- and 85-year-old women, respectively, and a 79-year-old man. Outcome was successful in all 3 cases after prolonged amoxicillin-clavulanic acid treatment, without relapse. CONCLUSION: C. fetus subspecies fetus is rarely associated with skin and soft tissue infections. Cardiovascular complications may be searched in such context.


Subject(s)
Bacteremia/microbiology , Campylobacter Infections/complications , Campylobacter fetus , Skin Diseases, Bacterial/microbiology , Aged , Aged, 80 and over , Campylobacter Infections/blood , Campylobacter fetus/isolation & purification , Cardiovascular Diseases/blood , Cardiovascular Diseases/microbiology , Female , Humans , Male , Skin Diseases, Bacterial/blood
18.
Astrophys J ; 812(1)2015 Oct 10.
Article in English | MEDLINE | ID: mdl-26568638

ABSTRACT

We present the first ~7.5'×11.5' velocity-resolved (~0.2 km s-1) map of the [C ii] 158 µm line toward the Orion molecular cloud 1 (OMC 1) taken with the Herschel/HIFI instrument. In combination with far-infrared (FIR) photometric images and velocity-resolved maps of the H41α hydrogen recombination and CO J=2-1 lines, this data set provides an unprecedented view of the intricate small-scale kinematics of the ionized/PDR/molecular gas interfaces and of the radiative feedback from massive stars. The main contribution to the [C ii] luminosity (~85 %) is from the extended, FUV-illuminated face of the cloud (G0>500, nH>5×103 cm-3) and from dense PDRs (G≳104, nH≳105 cm-3) at the interface between OMC 1 and the H ii region surrounding the Trapezium cluster. Around ~15 % of the [C ii] emission arises from a different gas component without CO counterpart. The [C ii] excitation, PDR gas turbulence, line opacity (from [13C ii]) and role of the geometry of the illuminating stars with respect to the cloud are investigated. We construct maps of the L[C ii]/LFIR and LFIR/MGas ratios and show that L[C ii]/LFIR decreases from the extended cloud component (~10-2-10-3) to the more opaque star-forming cores (~10-3-10-4). The lowest values are reminiscent of the "[C ii] deficit" seen in local ultra-luminous IR galaxies hosting vigorous star formation. Spatial correlation analysis shows that the decreasing L[C ii]/LFIR ratio correlates better with the column density of dust through the molecular cloud than with LFIR/MGas. We conclude that the [C ii] emitting column relative to the total dust column along each line of sight is responsible for the observed L[C ii]/LFIR variations through the cloud.

19.
Astron Astrophys ; 5792015 Jul 01.
Article in English | MEDLINE | ID: mdl-26543239

ABSTRACT

Cyanogen (NCCN) is the simplest member of the series of dicyanopolyynes. It has been hypothesized that this family of molecules can be important constituents of interstellar and circumstellar media, although the lack of a permanent electric dipole moment prevents its detection through radioastronomical techniques. Here we present the first solid evidence of the presence of cyanogen in interstellar clouds through the detection of its protonated form toward the cold dark clouds TMC-1 and L483. Protonated cyanogen (NCCNH+) has been identified through the J = 5 - 4 and J = 10 - 9 rotational transitions using the 40m radiotelescope of Yebes and the IRAM 30m telescope. We derive beam averaged column densities for NCCNH+ of (8.6 ± 4.4) × 1010 cm-2 in TMC-1 and (3.9 ± 1.8) × 1010 cm-2 in L483, which translate to fairly low fractional abundances relative to H2, in the range (1-10) × 10-12. The chemistry of protonated molecules in dark clouds is discussed, and it is found that, in general terms, the abundance ratio between the protonated and non protonated forms of a molecule increases with increasing proton affinity. Our chemical model predicts an abundance ratio NCCNH+/NCCN of ~ 10-4, which implies that the abundance of cyanogen in dark clouds could be as high as (1-10) × 10-8 relative to H2, i.e., comparable to that of other abundant nitriles such as HCN, HNC, and HC3N.

20.
Astron Astrophys ; 5572015 May.
Article in English | MEDLINE | ID: mdl-33154595

ABSTRACT

In the theory of star formation, the first hydrostatic core (FHSC) phase is a critical step in which a condensed object emerges from a prestellar core. This step lasts about one thousand years, a very short time compared with the lifetime of prestellar cores, and therefore is hard to detect unambiguously. We present IRAM Plateau de Bure observations of the Barnard 1b dense molecular core, combining detections of H2CO and CH3OH spectral lines and dust continuum at 2.3" resolution (~ 500 AU). The two compact cores B1b-N and B1b-S are detected in the dust continuum at 2mm, with fluxes that agree with their spectral energy distribution. Molecular outflows associated with both cores are detected. They are inclined relative to the direction of the magnetic field, in agreement with predictions of collapse in turbulent and magnetized gas with a ratio of mass to magnetic flux somewhat higher than the critical value, µ ~ 2 - 7. The outflow associated with B1b-S presents sharp spatial structures, with ejection velocities of up to ~ 7 kms-1 from the mean velocity. Its dynamical age is estimated to be ~ 2000 yr. The B1b-N outflow is smaller and slower, with a short dynamical age of ~ 1000 yr. The B1b-N outflow mass, mass-loss rate, and mechanical luminosity agree well with theoretical predictions of FHSC. These observations confirm the early evolutionary stage of B1b-N and the slightly more evolved stage of B1b-S.

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