1.
Bioorg Med Chem Lett
; 94: 129464, 2023 10 01.
Article
in English
| MEDLINE
| ID: mdl-37634760
ABSTRACT
Simplified analogues of the myxobacterial polyketide ajudazol were obtained by synthesis and evaluated for their biological activities. Potent simplified 5-lipoxygenase inhibitors were identified. Moreover, strong antiproliferative and apoptotic activities were observed in brain cancer cell lines at low nano- to micromolar concentrations.