ABSTRACT
Interferon status at different stages of atopic dermatitis was evaluated in 28 patients. Its dynamics and disturbances during standard therapy combined with cycloferon were clarified. Positive laboratory and clinical results of the combined treatment give reason to recommend it for the management of patients with atopic dermatitis.
Subject(s)
Acridines/therapeutic use , Dermatitis, Atopic/drug therapy , Dermatitis, Atopic/immunology , Interferon Inducers/therapeutic use , Interferons/immunology , Adolescent , Adult , Drug Therapy, Combination , Female , Humans , Interferons/blood , Male , Young AdultABSTRACT
Unilateral pyramidotomy at the bulbar level performed after preliminary elaboration of instrumental conditional reflex (ICR) and without its elaboration caused hemiparesis of extremities in rats. Next day after this operation a half of the operated animals both with elaborated ICE and without its elaboration was injected intramuscularly with bacterial melanin solution (170 mg/kg). Comparison of terms of recovery of ICR and of a balancing movement of the paralyzed hindleg in the operated rats without administration of melanin and with its injection showed that in the "melanin" animals the time of posttraumatic rehabilitation was much shorter and recovery of movement occurred faster and more completely. It has been found that the difference in terms of recovery of rat motor functions in this case is due to the protector action of bacterial melanin.
Subject(s)
Conditioning, Operant/drug effects , Locomotion/drug effects , Melanins/pharmacology , Pyramidal Tracts/surgery , Recovery of Function/drug effects , Animals , Bacteria/chemistry , Male , Melanins/chemistry , RatsABSTRACT
It has been shown the reinforcement of the corticofugal plasticity in adult rats after unilateral ablation of sensorimotor cortex accompanied by intramuscular injections of low concentrations of BT-melanin. In result the process of compensatory recovery in rats central nervous system is accelerated, confirmable by the rapid recovery of previously elaborated instrumental conditioned reflex in comparison with the control animals. It is assumed that the compensation of the motor deficit arised after the sensorimotor cortex ablation is ensured by the ability of two main motor systems of the brain (corticospinal and corticorubrospinal) to duplicate each other. This phenomenon of functional switching of descending influences has also been revealed in control group rats, not injected with BT-melanin. However the difference in time periods of operantly conditioned reflex recovery, for experimental and control groups, argues the apparent acceleration of this process, induced by the effects of BT-melanin. The obtained data considers the possibility of applied use of low concentrations of BT-melanin.
Subject(s)
Bacterial Proteins/pharmacology , Conditioning, Operant/drug effects , Melanins/pharmacology , Motor Activity/drug effects , Motor Cortex/drug effects , Somatosensory Cortex/drug effects , Animals , Bacillus thuringiensis , Male , Neural Pathways/drug effects , Neuronal Plasticity , RatsABSTRACT
The effects of unilateral transection of bulbar pyramids on instrumental conditioned reflexes in rats were shown to be in direct relationship with the time of its execution. In rats with stable conditioned reflexes, pyramidotomy impaired conditioned performance, on the average, for 3.9 days. However, preliminary transection of the pyramid delayed operant conditioning and its stabilization, on the average, by 16.5 day. The findings are discussed in terms of the mechanisms of switching over descending influences of the cortico-spinal and cortico-rubrospinal systems.
Subject(s)
Conditioning, Operant/physiology , Postural Balance/physiology , Pyramidal Tracts/physiology , Animals , RatsABSTRACT
Unilateral transection of bulbar pyramid performed prior to ablation of the ipsilateral sensomotor cortex was shown to facilitate recovery of operant conditioning and compensatory processes in rats. There was no such corticofugal plasticity in ablation of the sensomotor cortex alone. The phenomenon may be explained by switching of descending influences on the cortico-rubrospinal system through participation of the loop: corticorubral projection--red nucleus--inferior olive--cerebellum--thalamus--cerebral cortex.
Subject(s)
Conditioning, Operant/physiology , Motor Cortex/physiology , Pyramidal Tracts/physiology , Reflex/physiology , Somatosensory Cortex/physiology , Spinal Cord/physiology , Animals , Female , Functional Laterality , Male , RatsABSTRACT
Facilitated influence of preliminary transection of the rat rubrospinal tract on motor activity and instrumental reflexes recovering after lesion of the red nucleus was more obvious after a chemical lesion rather than the electrolytic lesion. This seems to be due to remaining cerebello-thalamic fibres after a chemical lesion of the red nucleus. A preliminary destruction of the ventrolateral thalamic nucleus was shown to complicate switching of the motor activity in the rats with transected rubrospinal tract and lesioned red nucleus.
Subject(s)
Lateral Thalamic Nuclei/physiology , Motor Activity/physiology , Ventral Thalamic Nuclei/physiology , Animals , Conditioning, Operant/physiology , Electrolysis , Female , Humans , Quinolinic Acid , Rats , Red Nucleus/physiology , Spinal Cord/physiologyABSTRACT
Training and recovery of instrumental equilibrium reflexes are impossible after total neurotoxical destruction of the inferior olive in rats. Motor deficits and compensatory rehabilitation processes in rats following 3-acethylpyridine treatment and high transection of the dorso-lateral funiculus of the spinal cord are closely correlated with the degree of the inferior olive destruction. The data obtained revealed an improvement in the motor disturbance and a stabilising of the instrumental reflexes in the rats with subtotal lesion of the inferior olive.
Subject(s)
Adaptation, Physiological/physiology , Conditioning, Operant/physiology , Olivary Nucleus/physiology , Pyridines/toxicity , Reflex/physiology , Animals , Female , Male , Olivary Nucleus/drug effects , Postural Balance/physiology , Rats , Spinal Cord/physiologyABSTRACT
In white non-strain rats with elaborated instrumental responses preliminary section of the rubro-spinal tract was shown to promote the compensatory restorative processes after the destruction of the red nucleus and the ventrolateral thalamic nucleus. Facilitation observed is considered to be a result of transfer of the motor activity to the cortico-spinal system due to activation of the inferior olive and the cerebellum.
Subject(s)
Adaptation, Physiological , Behavior, Animal/physiology , Red Nucleus/physiology , Thalamic Nuclei/physiology , Animals , Conditioning, Operant/physiology , Female , Male , Movement Disorders/etiology , Movement Disorders/physiopathology , Rats , Red Nucleus/surgery , Thalamic Nuclei/surgeryABSTRACT
High frequency stimulation of the mesencephalic reticular formation produces significant inhibition of neuronal activity in the sensorimotor cortex, the effect being equally observed in both hemispheres. In case of low frequency stimulation, marked difference was observed between the reaction of ipsi- and contralateral neurons. Under these conditions, contralateral neurons produce mainly facilitation responses. In both hemispheres evident predominance of tonic effects was observed which revealed itself in the continuation of the reaction in the poststimulation period. Single shocks applied to the midbrain reticular formation elicited in the cortex the evoked potentials of two types: one with a constant and the other with varying latent periods. The former exhibited a latency of 4-18 msec. Responses with varying latencies were predominant. In general, latent periods were longer in contralateral hemisphere.
