Propagation of cortical synfire activity: survival probability in single trials and stability in the mean.

The synfire hypothesis states that under appropriate conditions volleys of synchronized spikes (pulse packets) can propagate through the cortical network by traveling along chains of groups of cortical neurons. Here, we present results from network simulations, taking full account of the variability in pulse packet realizations. We repeatedly stimulated a synfire chain of model neurons and estimated activity (a) and temporal jitter (sigma) of the spike response for each neuron group in the chain in many trials. The survival probability of the activity was assessed for each point in (a, sigma)-space. The results confirm and extend our earlier predictions based on single neuron properties and a deterministic state-space analysis [Diesmann, M., Gewaltig, M.-O., & Aertsen, A. (1999). Stable propagation of synchronous spiking in cortical neural networks. Nature, 402, 529-533].

Neural dynamics in cortical networks--precision of joint-spiking events.

Electrophysiological studies of cortical function on the basis of multiple single-neuron recordings reveal neuronal interactions which depend on stimulus context and behavioural events. These interactions exhibit dynamics on different time scales, with time constants down to the millisecond range. Mechanisms underlying such dynamic organization of the cortical network were investigated by experimental and theoretical approaches. We review some recent results from these studies, concentrating on the occurrence of precise joint-spiking events in cortical activity, both in physiological and in model neural networks. These findings suggest that a combinatorial neural code, based on rapid associations of groups of neurons co-ordinating their activity at the single spike level, is biologically feasible.

Stable propagation of synchronous spiking in cortical neural networks.

The classical view of neural coding has emphasized the importance of information carried by the rate at which neurons discharge action potentials. More recent proposals that information may be carried by precise spike timing have been challenged by the assumption that these neurons operate in a noisy fashion--presumably reflecting fluctuations in synaptic input and, thus, incapable of transmitting signals with millisecond fidelity. Here we show that precisely synchronized action potentials can propagate within a model of cortical network activity that recapitulates many of the features of biological systems. An attractor, yielding a stable spiking precision in the (sub)millisecond range, governs the dynamics of synchronization. Our results indicate that a combinatorial neural code, based on rapid associations of groups of neurons co-ordinating their activity at the single spike level, is possible within a cortical-like network.

A model of computation in neocortical architecture.

We propose that the specific architecture of the neocortex reflects the organization principles of neocortical computation. In this paper, we place the anatomically defined concept of columns into a functional context. It is provided by a large-scale computational hypothesis on visual recognition, which includes both, rapid parallel forward recognition, independent of any feedback prediction, and a feedback controlled refinement system. Short epochs of periodic clocking define a global reference time and introduce a discrete time for cortical processing which enables the combination of parallel categorization and sequential refinement. The presented model differs significantly from conventional neural network architectures and suggests a novel interpretation of the role of gamma oscillations and cognitive binding.

Propagation of synchronous spiking activity in feedforward neural networks.

'Synfire' activity has been proposed as a model for the experimentally observed accurate spike patterns in cortical activity. We investigated the structural and dynamical aspects of this theory. To quantify the degree of synchrony in neural activity, we introduced the concept of 'pulse packets'. This enabled us to derive a novel neural transmission function which was used to assess the role of the single neuron dynamics and to characterize the stability conditions for propagating synfire activity. Thus, we could demonstrate that the cortical network is able to sustain synchronous spiking activity using local feedforward (synfire) connections. This new approach opens the way for a quantitative description of neural network dynamics, and enables us to test the synfire hypothesis on physiological data.