Subject(s)
Antibodies, Bacterial/blood , Borrelia burgdorferi Group/immunology , Erythema Chronicum Migrans/diagnosis , Exanthema/diagnosis , Facial Dermatoses/diagnosis , Child , Erythema Chronicum Migrans/microbiology , Erythema Chronicum Migrans/pathology , Exanthema/microbiology , Exanthema/pathology , Facial Dermatoses/microbiology , Facial Dermatoses/pathology , Humans , MaleSubject(s)
Anti-Inflammatory Agents/therapeutic use , Clofazimine/therapeutic use , Necrobiosis Lipoidica/drug therapy , Adult , Betamethasone/analogs & derivatives , Betamethasone/therapeutic use , Female , Humans , Immunosuppressive Agents/therapeutic use , Stockings, Compression , Tacrolimus/therapeutic useABSTRACT
Does controlled vascular training influence plasmaviscosity and the pain free walking distance in patients with peripheral arterial occlusive disease (paod) Fontaine stage II?37 patients, 24 men and 13 women with a mean age of 64.5 years SD 8.5 took part in ambulant vascular training over a period of 12 months.Before, after 6 months and after 12 months, pain free (pfwd) and maximum walking distance (mwd) was measured using a standardized treadmill program. Also ankle-brachials systolic pressure index (a-bspi), transcutaneous oxygen tension (tcPO2) and plasmaviscosity (pv) were measured.Pfwd increased from 212 SD 143 m to 371 SD 249 m (p<0.02). TcPO2 increased during training, but without statistically significance. A-bspi increased between the first 6 months of training statistically significant. Before training pv was 1.31 mPa s SD 0.10, after training period of 6 months it was 1.27 mPa s SD 0.11 (p=0.06) and 12 months later it was 1.28 SD 0.11 mPa s (p=0.35). The improvement of pfwd and the decrease of pv correlates (r=-0.39, p=0.05).In most patients, arterial vascular training improves pfwd and mwd. Simultaneously to the increase of the walking distances plasmaviscosity decreases and crurobrachial indexes increases. We found a coupling between improvement of pfwd and pv. Pv seems to participate in improvement of leg hemodynamics in patients with paod.
Subject(s)
Blood Viscosity , Exercise Therapy , Pain/rehabilitation , Peripheral Vascular Diseases/blood , Peripheral Vascular Diseases/rehabilitation , Aged , Exercise Test , Female , Humans , Leg/blood supply , Male , Middle Aged , Prospective Studies , WalkingABSTRACT
Pagetoid reticulosis (Woringer-Kolopp disease) is a rare subtype of cutaneous CD8-positive T-cell lymphoma. A 41-year-old man presented with a 7-year history with a slowly progressive erythematous plaque on his right buttocks. With the working diagnosis of psoriasis, he was treated with topical corticosteroids which produced no improvement. Histological examination showed an epidermotropic T-cell lymphoma with predominance of CD8- vs.CD4-positive lymphocytes. Based on the clinical picture and the histological findings, we diagnosed pagetoid reticulosis. Excision of the plaque and cream PUVA photo-chemotherapy produced long-term remission.
Subject(s)
Mycosis Fungoides/pathology , Mycosis Fungoides/therapy , PUVA Therapy , Adult , Humans , MaleABSTRACT
Breast cancer cell lines migrated towards a BMP-2 source depending on BMP-2 concentration. After a short exposure to BMP-2, the cells were able to migrate through matrigel. MCF-7 cells transfected with the BMP-2 gene also showed enhanced migratory properties and high expression of the metastasis-related gene BCSG1. In a xenograft model without estrogen supplementation MCF-7/BMP-2 cells formed tumors. These tumors were characterised by an enhanced vasculature and the formation of chondroid and osseous structures. In conclusion elevated levels of BMP-2 enhance the tumorigenic properties of breast carcinoma cells and drive the cells towards a more aggressive phenotype with estrogen independent growth.
