1.
Transplant Proc
; 20(1 Suppl 1): 233-6, 1988 Feb.
Article
in English
| MEDLINE
| ID: mdl-3279614
ABSTRACT
DSPG had a definite but relatively feeble immunosuppressive effect in rats undergoing heterotopic heart transplantation and in dogs after renal transplantation. The drug was toxic in both species, although less so in rats. In dogs, synergistic interactions with cyclosporine and steroids were not evident.
Subject(s)
Heart Transplantation , Immunosuppressive Agents/therapeutic use , Kidney Transplantation , Animals , Cyclosporins/administration & dosage , Dogs , Drug Therapy, Combination , Graft Rejection/drug effects , Guanidines/administration & dosage , Guanidines/therapeutic use , Guanidines/toxicity , Immunosuppressive Agents/toxicity , Prednisone/administration & dosage , Rats , Rats, Inbred ACI/immunology , Rats, Inbred Lew/immunology
2.
Transplant Proc
; 19(5 Suppl 6): 57-61, 1987 Oct.
Article
in English
| MEDLINE
| ID: mdl-2445076
ABSTRACT
The immunosuppressive agent FK permitted increased kidney transplant survival in dogs over a wide dose range, but with weight loss and manifold evidence of toxicity. The best use of FK at low doses was in combination with CyA and Pred.
