Performance assessment of the integration of semitransparent solar cells with different geometry of greenhouses under different climate regions.

A lack of resources and suitable farming lands, climate change, and a rapidly growing population are some of the main concerns of the societies that pose security challenges to the governments. Creating controlled environments for cultivation, growing plants, and farming, such as greenhouses, may assist in overcoming these challenges. Greenhouses can significantly increase land use efficiency in agriculture by increasing crop yield and harvesting throughout the year, which has long been proven effective. The history of greenhouses for farming dates back to Roman times, and there are different barriers to their applications. An example is the provision of energy to control the cultivation conditions of plants in greenhouses, particularly for heating and cooling hot and cold climate areas. On the other hand, based on the global energy trend, decentralized energy production based on solar energy is highly regarded. In the same way, that households can harvest solar energy, greenhouses can also benefit from solar energy. However, because greenhouses need sunlight to cultivate plants, reducing sunlight using common photovoltaic panels is not logical. By incorporating semitransparent solar cells into these greenhouses, the issue of reduced sunlight could be addressed, and further efficiency gains could be achieved by reducing energy demand in these greenhouses. This research investigates the energy supply system's integration with greenhouses consumption. First, we assess different conventional types of greenhouses in terms of energy demand. Then, we investigate the energy demand with organic photovoltaic (OPV) integration for each type. Finally, the best design of the greenhouse for OPV integration is recommended. Results show that flat arch geometry is the best choice for dry and cold climates, while sawtooth geometry showed better improvements in tropical climates. In both temperate/mesothermal and continental/microthermal climates, A-frame geometry showed superiority in energy saving. Simulations revealed an annual electricity generation for a unit floor area of the greenhouses to be 173.7 kWh/m2 to 247.9 MWh/m2 for the optimum structural geometries that decrease the energy consumption of greenhouses. Additionally, the results show that the installation of the OPV can decrease energy consumption from 15 to 58% based on the greenhouse's location and structural geometry.

Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients.

Oxidative abnormalities precede clinical and pathological manifestations of Alzheimer's disease and are the earliest pathological changes reported in the disease. The olfactory pathways and mucosa also display the pathological features associated with Alzheimer's disease in the brain. Olfactory neurons are unique because they can undergo neurogenesis and are able to be readily maintained in cell culture. In this study, we examined neuronal cell cultures derived from olfactory mucosa of Alzheimer's disease and control patients for oxidative stress responses. Levels of lipid peroxidation (hydroxynonenal), N(epsilon)-(carboxymethyl)lysine (glycoxidative and lipid peroxidation), and oxidative stress response (heme oxygenase-1) were measured immunocytochemically. We found increased levels for all the oxidative stress markers examined in Alzheimer's disease neurons as compared to controls. Interestingly, in one case of Alzheimer's disease, we found hydroxynonenal adducts accumulated in cytoplasmic lysosome-like structures in about 20% of neurons cultured, but not in neurons from control patients. These lysosome-like structures are found in about 100% of the vulnerable neurons in brains of cases of Alzheimer's disease. This study suggests that manifestations of oxidative imbalance in Alzheimer's disease extend to cultured olfactory neurons. Primary culture of human olfactory neurons will be useful in understanding the mechanism of oxidative damage in Alzheimer's disease and can even be utilized in developing therapeutic strategies.

Oxidative damage in the olfactory system in Alzheimer's disease.

Increased oxidative damage is a prominent and early feature of vulnerable neurons in Alzheimer's disease (AD). However, while damage to proteins, sugars, lipids, nucleic acids and organelles such as lysosomes, mitochondria, and endoplasmic reticulum are evident, the source of increased reactive oxygen species has not been determined. Furthermore, a major limitation in further determining the source, as well as finding a means to arrest damage, is the paucity of cellular models directly homologous to AD since the vulnerable neurons of the brain in AD cannot be studied in vitro. Here, we examined the olfactory epithelium in situ to see if neurons there exhibit a similar pathological oxidative balance to vulnerable neurons in AD. In biopsy specimens, (eight AD and three controls) we found that neurons, and also the surrounding epithelial cells, show an increase in oxidative damage for a subset of the markers increased in the brain of cases of AD. Lipid peroxidation and heme oxygenase-1, a stress response protein, were increased, while nucleic acid or protein oxidation, demonstrated in vulnerable neurons in AD, were not increased. These findings highlight the systemic nature of oxidative abnormalities in AD, but that different cell types may express this abnormality by a different array of oxidative stress markers, supporting the potential for using olfactory neurons or other cells derived from AD patients in culture to understand the mechanistic basis for increased oxidative damage in AD and as a model to screen compounds for therapeutic intervention.