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Int J Mol Sci ; 18(4)2017 Apr 20.
Article in English | MEDLINE | ID: mdl-28425970

ABSTRACT

Altered microRNA expression is implicated in cardiovascular diseases. Our objective was to determine microRNA signatures in thoracic aortic aneurysms (TAAs) and abdominal aortic aneurysms (AAAs) compared with control non-aneurysmal aortic specimens. We evaluated the expression of fifteen selected microRNA in human TAA and AAA operative specimens compared to controls. We observed significant upregulation of miR-221 and downregulation of miR-1 and -133 in TAA specimens. In contrast, upregulation of miR-146a and downregulation of miR-145 and -331-3p were found only for AAA specimens. Upregulation of miR-126 and -486-5p and downregulation of miR-30c-2*, -155, and -204 were observed in specimens of TAAs and AAAs. The data reveal microRNA expression signatures unique to aneurysm location and common to both thoracic and abdominal pathologies. Thus, changes in miR-1, -29a, -133a, and -221 are involved in TAAs and miR-145, -146, and -331-3p impact AAAs. This work validates prior studies on microRNA expression in aneurysmal diseases.


Subject(s)
Aortic Aneurysm, Abdominal/genetics , Aortic Aneurysm, Thoracic/genetics , Genetic Predisposition to Disease , MicroRNAs/genetics , Aged , Aortic Aneurysm, Abdominal/diagnosis , Aortic Aneurysm, Thoracic/diagnosis , Case-Control Studies , Cluster Analysis , Computational Biology/methods , Female , Gene Expression Profiling , Genetic Association Studies , Humans , Male , Middle Aged , Risk Factors , Transcriptome
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