Biomarkers and Corresponding Biosensors for Childhood Cancer Diagnostics.

Although tremendous progress has been made in treating childhood cancer, it is still one of the leading causes of death in children worldwide. Because cancer symptoms overlap with those of other diseases, it is difficult to predict a tumor early enough, which causes cancers in children to be more aggressive and progress more rapidly than in adults. Therefore, early and accurate detection methods are urgently needed to effectively treat children with cancer therapy. Identification and detection of cancer biomarkers serve as non-invasive tools for early cancer screening, prevention, and treatment. Biosensors have emerged as a potential technology for rapid, sensitive, and cost-effective biomarker detection and monitoring. In this review, we provide an overview of important biomarkers for several common childhood cancers. Accordingly, we have enumerated the developed biosensors for early detection of pediatric cancer or related biomarkers. This review offers a restructured platform for ongoing research in pediatric cancer diagnostics that can contribute to the development of rapid biosensing techniques for early-stage diagnosis, monitoring, and treatment of children with cancer and reduce the mortality rate.

Hyper IgE syndromes: A clinical approach.

Hyper IgE syndromes (HIESs) are a group of rare inborn errors of immunity with a triad of eczema, increase susceptibility to sinopulmonary and skin infections with high level of IgE serum. Although most of HIESs are sporadic, hereditary types of these disorders have been studied well. There are several distinct immunodeficiency disorders which are phenotypically similar to HIES, and thus make the diagnosis of HIES challenging. In fact, the diagnosis of HIES is typically based on the clinical suspicion and immunological assessments. There is yet no specific curative treatment for most of HIESs at present, and the treatments are mostly standing on early diagnosis and preventive therapies. For instance, the genetic diagnosis is an important module, while, due to DOCK8 mutations, the hematopoietic stem cell transplantation is necessary for patients with autosomal recessive form of HIESs. Herein, we overview HIESs, highlight their peculiar clinical and laboratory features, and finally suggest a practical forthright diagnostic chart for clinical purposes.

Comparative analyses of umbilical cord lead concentration in term and IUGR complicated neonates.

BACKGROUND: Lead as a toxic heavy metal can readily transfer through the placenta; this condition may increase the risk of lead toxicity for a developing fetus. Therefore, we undertook this study to evaluate the association between umbilical cord blood lead levels and the risk of intrauterine growth restriction (IUGR) occurrence. METHODS: A cross-sectional study was done at an academic hospital (Tehran, Iran, 2017). The population study was term and IUGR complicated neonates. Immediately after birth, 3-ml umbilical cord blood was collected in some tubes and sent to a laboratory to assay plasma lead levels. Demographic data related neonates and their mothers were gathered from the medical record. All recorded data were analyzed to compare the cord blood lead levels among normal term and IUGR neonates as the primary outcome. RESULTS: Totally 152 neonates, 76 in each group with inclusion criteria entered the study. Of all neonates, 71 subjects (47%) were male. The mean (±SD) cord blood lead levels was 6.5 ± 4.2 µg/l. Of all neonates, 102 (67.1%) had high cord blood lead levels (≥5 µg/dl) and 50 subjects (32.8%) had low cord blood lead levels (<5 µg/dl). The mean gestational age, birth weight and head circumference of term neonates were significantly higher than IUGR complicated neonates (p-value = .0001). On the other hand, no significant difference was observed between two groups regarding the mean cord blood lead concentrations (6.2 ± 2.2 and 6.8 ± 5.6 µg/dl; p-value = .855). ANOVA analyses showed no relationships between cord blood lead levels and all assessed qualitative variables except from mother's educational status (in IUGR group; p-value = .048 and in term group; p-value = .010). CONCLUSION: Our results highlighted that IUGR occurrence was not associated with fetal blood lead levels alone. Moreover, highly educated mothers had neonates with low blood lead levels, showing that maternal education may be a potentially protective factor against this toxin exposure in newborns. The majority of neonates in the present study had high blood lead concentrations that show a necessity for more efforts and strategies regarding protection against potential deleterious effects of lead toxicity.