ABSTRACT
We report a case of keratitis due to Rhodotorula species in an agricultural worker following trauma with sugarcane leaf. There are very few cases of Rhodotorula infection in corneal grafts following lamellar keratoplasty. This is a unique case reporting Rhodotorula infection after traumatic corneal ulcer.
Subject(s)
Corneal Transplantation/adverse effects , Eye Injuries/complications , Keratitis/diagnosis , Keratitis/microbiology , Mycoses/diagnosis , Mycoses/microbiology , Rhodotorula/isolation & purification , Adult , Agriculture , Bacteriological Techniques , Eye Injuries/surgery , Humans , Male , Plant Leaves , SaccharumABSTRACT
A novel series of 14 new isonicotinyl hydrazide derivatives 2a-g, 3a-g containing a 4-thiazolidinone / 2-azetidinone nucleus were synthesized by reacting N'-substituted arylidene / heteroarylidene isonicotinyl hydrazide 1a-g with thioglycollic acid in the presence of dry benzene and with chloroacetyl chloride in the presence of triethylamine, respectively. Structures of all newly synthesized compounds were characterized on the basis of elemental analyses and spectral data (IR and (1)H-NMR). All the title compounds were tested for their in-vitro antimycobacterial activity against Mycobacterium tuberculosis H(37)Rv using Alamar-Blue susceptibility test, and the activity is expressed as the minimum inhibitory concentration (MIC) in microg/mL. Among the series, compounds 2b, 2g, 3b, and 3g displayed an encouraging antimycobacterial activity profile as compared to that of the reference drugs isoniazid / rifampicin.
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/pharmacology , Isoniazid/analogs & derivatives , Isoniazid/pharmacology , Mycobacterium tuberculosis/drug effects , Isoniazid/chemical synthesis , Microbial Sensitivity Tests , Molecular Structure , Structure-Activity RelationshipABSTRACT
Beta lactamase production is an important mechanism of developing resistance to beta lactam group of antibiotics. Cephlosporins with extended spectrum of activity and stability were introduced to overcome this resistance, but soon production of extended spectrum beta lactamases (ESBLs), which are inducible in nature was reported. In this study Klebsiella aerogenes--166, Escherichia coli--120, Citrobacter spps--116, Pseudomonas spps--50, Proteus spps--32 and S. typhi--16, strains were subjected to sensitivity testing against various generations of cephalosporins by disc diffusion method and for the production of ESBLs using disc approximation method. Klebsiella aerogenes, Escherichia coli, Citrobacter spps and Pseudomonas spps showed statistically significant difference in the resistance pattern to all three generations of cephalosporins and ESBLs production.
