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J Pediatr Endocrinol Metab ; 17(2): 235-8, 2004 Feb.
Article in English | MEDLINE | ID: mdl-15055361

ABSTRACT

We report a 5.5 year-old girl with a benign adrenocortical adenoma who presented with virilization and rapid growth. She did not have any clinical features of isosexual precocity or, except for hypertension, Cushing's syndrome. Measurement of hormones in adrenal vein blood obtained at surgery showed high concentrations of testosterone, cortisol, estradiol and intermediary substrates. Elevated levels of hormones detected in the peripheral blood were released directly from the tumor and were not the result of peripheral interconversion. Hyperandrogenism can obscure the clinical features of Cushing's syndrome and estrogen hypersecretion in patients with functional adrenal tumors.


Subject(s)
Adrenal Cortex Neoplasms/metabolism , Estradiol/metabolism , Hydrocortisone/metabolism , Acne Vulgaris/etiology , Adrenal Cortex Neoplasms/complications , Adrenal Cortex Neoplasms/surgery , Child, Preschool , Cushing Syndrome/blood , Cushing Syndrome/diagnosis , Cushing Syndrome/metabolism , Female , Growth Disorders/etiology , Hormones/blood , Humans , Hypertension/physiopathology , Puberty, Precocious/etiology
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