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Identification of two novel variants in PRKAG2 gene in Tunisian type 2 diabetic patients with family history of cardiovascular disease.

Nouira, S; Arfa, I; Kammoun, I; Abid, A; Ouragini, H; Dorboz, I; Ghazouani, W; Fadhel, S Ben; Zorgati, M M; Ammar, S Ben; Blousa-Chabchoub, S; Kachboura, S; Abdelhak, S.

Diabetes Res Clin Pract ; 87(2): e7-10, 2010 Feb.

Article in English | MEDLINE | ID: mdl-20022652

ABSTRACT

We report the identification of two novel polymorphisms in the PRKAG2 gene and preliminary association study between 5'-UTR and exon 1 polymorphisms with susceptibility to type 2 diabetes. No association with type 2 diabetes was identified. However, one of these newly identified polymorphisms (p.Ser20Ile) is likely associated with cardiac disease.

Subject(s)

AMP-Activated Protein Kinases/genetics , Cardiovascular Diseases/genetics , Diabetes Mellitus, Type 2/genetics , Diabetic Angiopathies/genetics , Exons/genetics , Genetic Variation , Polymorphism, Single Nucleotide , 5' Untranslated Regions/genetics , Age of Onset , Aged , Base Sequence , Diabetes Mellitus, Type 2/complications , Humans , Medical History Taking , Middle Aged , Molecular Sequence Data , Reference Values , Sequence Alignment , Sequence Homology, Nucleic Acid , Tunisia

ABSTRACT

Subject(s)

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