ABSTRACT
STATEMENT OF PROBLEM: The most common method for parotid duct anastomosis is suturing. A ductal defect of greater than 1cm may prevent a direct anastomosis. PURPOSE: The goal of this study was a sialographic evaluation to compare repairing a parotid duct with facial vein graft versus Gore-Tex tub in 19 dogs. MATERIAL AND METHODS: Nineteen dogs were studied in this experimental trial. Extra oral transverse incisions were made in buccal regions bilaterally to expose parotid ducts and a defect (2 cm) was performed in similar areas (right and left). The right resected duct was repaired with facial vein graft and the left anastomosis was performed by using the Gore-Tex tube microscopically. Sialography was used to evaluate the ductal leakage. Statistical analysis was performed, using SPSS software and McNemar's test. RESULTS: Based on the sialography evaluation; the ductal leakage was seen in five cases (26.31%) on the right side and in seven cases (36.84%) in the left side. Statistical analysis using McNemar's test suggested no statistically significant difference between ductal leakages in right and left parotid ducts (p> 0.05). CONCLUSION: The results of this study suggest that the efficacies of Gore-Tex tube and vein graft in parotid duct anastomosis are similar, but the use of Gore-Tex tube had a number of advantages, including reduced morbidity of the graft and short operation time.
ABSTRACT
UNLABELLED: We have performed a monocenter study on 29 consecutive patients with acquired haemophilia A who were referred for diagnosis and treatment to the Düsseldorf Haemophilia Comprehensive Care Center between March 2001 and February 2010. PATIENTS, METHODS: 18 men (age: 44-86 years) and 11 women (age: 20-83 years). For laboratory evaluation, a standardized staged protocol of aPTT, FVIII:C activity and concentration, mixing studies with patient and normal plasma, and quantification of inhibitor titers (Bethesda assay) was used. Diagnostic work-up included elaborate examinations for any underlying disease. RESULTS: In 18 (62%) of the 29 patients with acquired haemophilia A, an underlying disorder was identified, including 9 patients with respiratory diseases (31%), 7 patients with autoimmune disorders (24%), one with malignancy, and one with postpartum state, while in 11 patients (38%) acquired haemophilia A remained idiopathic. Haemotherapy of bleeding, suppression or elimination of the inhibitor, and induction of immunotolerance to endogenous FVIII:C were performed according to a treatment algorithm. Predefined clinical endpoints were control of bleeding, eradication of the inhibitor, complete or partial remission (CR, PR), relapse, or early death (< or =30 days). Of the 29 patients in total, 22 individuals achieved CR (76%), three had PR, one relapsed, and three died within 30 days (one of acute myocardial infarction while on antihaemorrhagic treatment, one of sepsis while on immunosuppression due to active acquired haemophilia A, one of lung bleeding in association with pre-existing pulmonary sarcoidosis). CONCLUSION: This monocenter study demonstrates that control of life-threatening bleeding, eradication of the inhibitor, and induction of tolerance to endogenous FVIII have significantly improved the clinical outcome of acquired haemophilia A. Our data also suggest a shift in underlying disorders associated with acquired haemophilia A, whereby, in comparison to published studies, a relative increase in the proportion of patients with respiratory diseases is present.
