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2.
Med Interne ; 19(4): 347-57, 1981.
Article in English | MEDLINE | ID: mdl-7336095

ABSTRACT

The effect of Silymarin (Legalon) upon liver lesions was investigated using four experimental models: In acute galactosamine-hepatitis, Silymarin administration achieved protection of the liver structure (electron-microscopy included), liver cell glycogen, RNA and enzymatic activity, Galactosamine-depressed gluconeogenesis in the isolated perfused rat liver was significantly preserved by Silymarin treatment. In lead and cadmium poisoning the structural damage and histochemical and histoenzymatic changes were partly but significantly prevented. The complex noxious effects of Imuran overdoses were favourably influenced by Silymarin, without diminishing the cytostatic-immunosuppressive action of Imuran.


Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Flavonoids/therapeutic use , Galactosamine/adverse effects , Hepatitis, Animal/drug therapy , Silymarin/therapeutic use , Animals , Azathioprine/poisoning , Cadmium Poisoning/drug therapy , Chemical and Drug Induced Liver Injury/etiology , Hepatitis, Animal/chemically induced , Lead Poisoning/drug therapy , Rats , Rats, Inbred Strains
3.
J Appl Toxicol ; 1(5): 284-6, 1981 Oct.
Article in English | MEDLINE | ID: mdl-7185889

ABSTRACT

Thirty-six healthy albino rats were divided into three groups and the histologic structure of the testes was examined after treatment: group 'C'--10 healthy control rats were untreated; group 'Pb'--eight rats received intraperitoneal injections of 8.5 mg per kg body weight lead acetate for 154 days (15 doses in all); group 'PbA'--eight rats intoxicated with lead, like group 'Pb' but which, during the last 21 days before killing, were treated with 5 ml per kg body weight per day of a 2% injectable solution of sodium aspartate. As compared with the controls, group 'Pb' showed alteration of the histopathologic pattern and reduction in the size of seminiferous tubules, basal membrane separation and a decrease in the cell content of the germinal layer, lesions of the spermatocytes and spermatids, and slight oedematous dissociation in the interstice. In 75% of the group 'PbA' animals, normal aspects similar to those of group 'C' were found.


Subject(s)
Lead/toxicity , Testis/pathology , Animals , Aspartic Acid/pharmacology , Male , Rats , Testis/drug effects
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