ABSTRACT
The difficulties of a positive diagnosis in the spongiform encephalopathies based only on epidemiological and clinical data are briefly reviewed. However, in B.S.E. as in scrapie, the epidemiology and the clinical data may frequently suggest these diseases. The main diseases which must be taken into account in the differential diagnosis of both spongiform encephalopathies are discussed and the criteria of the differential diagnosis are tabulated.
Subject(s)
Encephalopathy, Bovine Spongiform/diagnosis , Animals , Cattle , Diagnosis, Differential , Encephalopathy, Bovine Spongiform/epidemiology , Europe/epidemiology , Scrapie/diagnosis , Scrapie/epidemiology , SheepABSTRACT
Four organotin derivatives (tributyltin acid, dibutyltin chloride, triphenyltinchloride, and triphenyltin-bis (diethyl) dithiophosphate) were tested through subchronic treatment on 19 days old chickens. Growth dynamics as well as carbohydrate and protein metabolism were investigated, in order to evaluate their effects on metabolic activity. Biochemical liver and blood constituents revealed growth retardation and general depression of metabolic activity in experimental groups. Some correlations were found to exist chemical structure, dose use for compound, and effects. Butyltins were more toxic than phenylderivatives and their effects were proportionale to the dose.
