ABSTRACT
1-5% of cancer patients treated with cytotoxic chemotherapy die within a month after the administration of chemotherapy. Risk factors for these early deaths (ED) are not well known. The purpose of this study was to establish a risk model for ED after chemotherapy applicable to all tumour types. The model was delineated in a series of 1051 cancer patients receiving a first course of chemotherapy in the Department of Medicine of the Centre Léon Bérard (CLB) in 1996 (CLB-1996 cohort), and then validated in a series of patients treated in the same department in 1997 (CLB-1997), in a prospective cohort of patients with aggressive non-Hodgkin's lymphoma (NHL) (CLB-NHL), and in a prospective cohort of patients with metastatic breast cancer (MBC series) receiving first-line chemotherapy. In the CLB-1996 series, 43 patients (4.1%) experienced early. In univariate analysis, age > 60, PS > 1, lymphocyte (ly) count Subject(s)
Antineoplastic Agents/therapeutic use
, Lymphoma/mortality
, Neoplasms/mortality
, Adolescent
, Adult
, Age Factors
, Aged
, Aged, 80 and over
, Cohort Studies
, Female
, France/epidemiology
, Humans
, Incidence
, Lymphoma/drug therapy
, Male
, Middle Aged
, Neoplasms/drug therapy
, Prognosis
, Retrospective Studies
, Risk Factors
, Survival Rate