ABSTRACT
BACKGROUND: Corona virus disease (COVID-19) is a global pandemic public health problem which affected more than 5 million worldwide and caused more than 500,000 deaths. Disease presentations varied from a symptomatic or mild to severe illness which leads to death. AIM: The study describes the demographic and clinical characteristics patients with coronavirus disease 2019 (COVID-19) admitted to Security Forces Hospital in Riyadh, Saudi Arabia between 15th March till 30th of June 2020. METHODS: Study group studied a case series of 566 consecutive patients with COVID-19 evaluated at Security Forces Hospital in Riyadh, Saudi Arabia from 15th March and 30th June 2020. MAIN OUTCOMES: Demographic data, underlying co-morbidities, clinical presentation, and treatment were collected. RESULTS: Demographically, COVID-19 was more prevalent in male, Saudi, nonsmokers with blood group O + ve patients. It's more common in patients with co-morbidities like diabetes and hypertension. Fever, cough, and shortness of breath are the most common presenting symptoms. ESR, CRP, LDH, and Ferretin are the commonest laboratory abnormalities found. CONCLUSION: Totally, 556 case series patients showed more prevalence in aged male with diabetes as co-morbidity. Fever and cough are the most presenting symptoms with high inflammatory markers.
ABSTRACT
AIM: To find out if there is any correlation between COVID-19 antibody serological testing and symptom severity. METHODS: This study is a case series of 44 consecutive patients confirmed with COVID-19 who are divided into a group of 23 patients with mild disease and a group of 21 patients with severe disease. All 44 samples were confirmed positive SARS-CoV-2. Subsequent recombinant SARS-CoV-2 S1/S2 IgG test was performed for all patients and all patients developed neutralizing antibodies with altered range. MAIN OUTCOMES: IgG level and its correlation with disease severity, demographic data, underlying comorbidities, clinical presentation, and treatment comparison between mild and severe disease groups. RESULTS: Quantitative SARS COV-2 IgG was significantly higher in moderate and severe disease groups compared with those in the mild disease group. COVID-19 infection was more prevalent in male, Saudi nationals and smokers with comorbidities and higher inflammatory markers are more in the severe group than in the mild group which necessitates more management options to be taken for severe group patients. CONCLUSION: IgG antibody level was higher in the severe disease group. Also, the study showed significant differences between the mild and severe disease groups in terms of demographic, clinical, and management variables.
