Subject(s)
Scrub Typhus/microbiology , Cameroon , Humans , Male , Middle Aged , Orientia tsutsugamushiABSTRACT
AIM: To detect the prevalence of herpes virus-like DNA sequences in AIDS associated Kaposi sarcoma (KSHV) lesions and normal tissue. METHODS: KSHV detection was performed by polymerase chain reaction (PCR) using four different sets of primers. PCR products were cloned, sequenced, and analysed. RESULTS: All of four biopsies of Kaposi sarcoma lesions and all of three paraffin embedded Kaposi sarcoma tissues were positive for KSHV, while normal tissue from the same patients was negative. Sequence analysis of amplification products revealed polymorphisms that result in amino acid changes of the predicted sequence. CONCLUSIONS: KSHV is prevalent in tissues from Kaposi sarcoma, suggesting a role in the development of the tumour. On this basis, anti-herpes virus agents should be considered to control Kaposi sarcoma.
Subject(s)
Acquired Immunodeficiency Syndrome/virology , Herpesviridae/isolation & purification , Sarcoma, Kaposi/virology , Acquired Immunodeficiency Syndrome/complications , Amino Acids/analysis , Base Sequence , DNA, Viral/analysis , Humans , Molecular Sequence Data , Polymerase Chain Reaction , Sarcoma, Kaposi/etiologySubject(s)
Facial Dermatoses/etiology , Hamartoma/diagnosis , Paget Disease, Extramammary/diagnosis , Skin Neoplasms/diagnosis , Skin Ulcer/etiology , Toes/abnormalities , Trigeminal Nerve Injuries , Adult , Aged , Craniotomy/adverse effects , Facial Dermatoses/diagnosis , Facial Dermatoses/therapy , Female , Humans , Male , Skin Ulcer/diagnosis , Skin Ulcer/therapy , SyndromeABSTRACT
Scurvy is caused by a deficiency of ascorbic acid. We describe a 31-year-old Hispanic man who had perifollicular hemorrhages, follicular hyperkeratosis, corkscrew hairs, and gingival hemorrhage after consuming a peculiar and restricted diet for 1 year. A diagnosis of scurvy was made and the patient's disease resolved after treatment with vitamin C.
