ABSTRACT
Total anomalous pulmonary venous connection is a rare congenital heart disease in which the pulmonary veins drain anomalously into the right atrium or its tributaries. The condition manifests from infancy and has a high mortality rate in infancy and childhood.
Subject(s)
Pulmonary Veins/abnormalities , Child , Humans , Male , Pulmonary Veins/surgeryABSTRACT
A two-way cross-over trial comparing the effects of acebutolol and propranolol on the lipid profile was conducted. 50 patients were evaluated. The primary objective was to determine whether treatment by certain classes of beta-blockers induced deleterious effects on the serum lipids which could partially or wholly negate the beneficial effect of controlling hypertension. Each patient served as his/her own control, and received 6 weeks of therapy with acebutolol and 6 weeks of therapy with propranolol. The analysis of the results revealed that acebutolol did not have any adverse effect on the lipid profile in contrast to reports which implicate other beta-blockers in inducing pro-atherogenic changes in the serum lipid profile; but acebutolol and propranolol were equi-effective in controlling hypertension.
Subject(s)
Acebutolol/therapeutic use , Hypertension/drug therapy , Lipids/blood , Propranolol/therapeutic use , Acebutolol/adverse effects , Adult , Female , Humans , Hypertension/blood , Male , Middle Aged , Propranolol/adverse effectsABSTRACT
Two cases of middle aortic syndrome in children are described along with two other cases reported earlier. In childhood, this disease may present as incipient or overt cardiac failure. Surgical treatment should be undertaken based on an objective assessment of the severity of the stricture and after taking into account the future growth of the child.
