ABSTRACT
To describe maternal complications and neonatal outcomes caused by gestational diabetes mellitus a descriptive observational study was conducted in the department of obstetrics and gynaecology at Ramakrishna Mission Seva Pratisthan and Vivekananda Institute of Medical Sciences, Kolkata, over a period of one year from July 2009 to June 2010. Women diagnosed by oral glucose tolerance test as gestational diabetes mellitus were enrolled as study subjects and were followed regularly at outpatient department. Blood glucose levels controlled by diet or with insulin. Foetal well-being was assessed by ultrasonography, foetal kick count and cardiotocography. Time and mode of delivery were decided on admission depending upon the complications encountered. Intrapartum blood glucose level was monitored and foetal monitoring was done. After delivery all the babies were assessed by the paediatrician. After discharge patients were advised oral glucose tolerance test at 6 weeks postpartum. Out of 644 women delivered, 58 (9%) were diagnosed gestational diabetes mellitus and were studied. Mean age was 30 years and 55.2% were multigravida; 50% were obese (BMI > or = 30 kg/m2); 60.3% required insulin therapy to achieve glycaemic control. Most common maternal and neonatal complications observed were premature prelabour rupture of membrane (10.3%) and jaundice (29.3%) respectively. Caesarean section was done in 60.3% gestational diabetas mellitus mothers. A total of 57 babies (98.2%) were delivered alive.
Subject(s)
Delivery, Obstetric , Diabetes Complications/epidemiology , Diabetes, Gestational/etiology , Infant, Newborn, Diseases/epidemiology , Adult , Cohort Studies , Diabetes Complications/diagnosis , Diabetes, Gestational/diagnosis , Diabetes, Gestational/therapy , Female , Humans , India , Infant , Infant, Newborn , Infant, Newborn, Diseases/diagnosis , Pregnancy , Pregnancy OutcomeABSTRACT
OBJECTIVE: To control the birth of thalassemic children in India. METHODS: Mutations present in the population of eastern India and in carrier parents seeking prenatal diagnosis were detected by the PCR-based technique of ARMS (amplification refractory mutation system) or gap-PCR. To screen for maternal tissue contamination in CVS, haplotypes associated with the beta-globin gene clusters were constructed using six polymorphic restriction sites. Prenatal diagnosis was accomplished by checking presence of parental mutation in the DNA from chorionic villus sampling (CVS) collected at 8 to 10 weeks' gestation by appropriate technique. RESULTS: Six hundred and fifty (650) unrelated beta-thalassemia chromosomes were screened for 11 common mutations to characterize the mutation distribution in this population. Starting from early 2000, 63 families from different parts of West Bengal and from surrounding areas have been offered prenatal counseling for beta-thalassemia. CONCLUSION: The population of this region is conscious and willing to accept prenatal diagnosis as a means of control of thalassemia.
