Correcting Presbyopia With Autofocusing Liquid-Lens Eyeglasses.

OBJECTIVE: Presbyopia, an age-related ocular disorder, is characterized by the loss in the accommodative abilities of the human eye. Conventional methods of correcting presbyopia divide the field of view, thereby resulting in significant vision impairment. We demonstrate the design, assembly and evaluation of autofocusing eyeglasses for restoration of accommodation without dividing the field of view. METHODS: The adaptive optics eyeglasses comprise of two variable-focus liquid lenses, a time-of-flight range sensor and low-power, dual microprocessor control electronics, housed within an ergonomic frame. Subject-specific accommodation deficiency models were utilized to demonstrate high-fidelity accommodative correction. The abilities of this system to reduce accommodation deficiency, its power consumption, response time, optical performance and MTF were evaluated. RESULTS: Average corrected accommodation deficiencies for 5 subjects ranged from -0.021 D to 0.016 D. Each accommodation correction calculation was performed in ∼67 ms which consumed 4.86 mJ of energy. The optical resolution of the system was 10.5 cycles/degree, and featured a restorative accommodative range of 4.3 D. This system was capable of running for up to 19 hours between charge cycles and weighed ∼132 g. CONCLUSION: The design, assembly and performance of an autofocusing eyeglasses system to restore accommodation in presbyopes has been demonstrated. SIGNIFICANCE: The new autofocusing eyeglasses system presented in this article has the potential to restore pre-presbyopic levels of accommodation in subjects diagnosed with presbyopia.

Creep deformation in elastomeric membranes of liquid-filled tunable-focus lenses.

Liquid-filled tunable-focus lenses have been demonstrated to be suitable for autofocus eyewear applications. Traditionally, these lenses are constructed using an elastomeric polymer chamber filled with a high-index liquid. In this work, we investigate the effect of elastomeric creep on the deformation and eventual degradation of these tunable lenses. We use numerical analysis of a deformable circular disk representative of the lens and provide rigorous experimental results testing the creep property of a number of elastomers. Finally, we provide a comparative study of different elastomeric materials and select the best one for this application.

A Low-Profile Digital Eye-Tracking Oculometer for Smart Eyeglasses.

Wearable eye tracking devices have broad uses in medicine, psychology, augmented & virtual reality and consumer market research. Most mobile eye trackers available today utilize infrared imaging of the pupil and corneal reflections with video cameras. This tracking method requires sophisticated real-time processing of video signals consuming substantial electrical power. This method is thus unsuitable for light weight wearables such as adaptive smart eyeglasses for correction of presbyopia. In this paper we present a low-profile, low-power (7.7 mJ/sample) digital eye tracker oculometer based on infrared sclera tracking. The system is implemented using eight, 24-bit infrared proximity sensors and synchronous infrared LEDs. The pupil location is determined from 32 reflected pulsed light measurements independent of ambient illumination. The digital oculometer is 3.1 mm thick and weighs ~3 g. The tracker mounts adjacent to the tunable lenses in the smart eyeglasses frame. The eye tracker showed a pointing error of 1.3 degrees rms over a vertical and horizontal range of 30 degrees when tested by an observer.

Fast measurement of binding kinetics with dual slope SPR microchips.

We demonstrate a new dual slope SPR technique that is ten-fold faster than the conventional step-response method. The new scheme utilizes rapid slope-based measurements followed by rapid reset, and it separates association and dissociation half reaction measurements at two separate sites inside a dual-chamber PDMS microfluidic chip. For a model CAII-ABS test system, the association and dissociation slopes were measured in 30 seconds compared to 5 minutes for step-response. The values of k(a) and k(d) calculated from the slope method are 3.66 ± 0.19 × 10(3) M(-1) s(-1) and 4.83 ± 0.17 × 10(-2) s(-1), respectively, matching well with step-response values while facilitating ~10 to 15 fold faster detection and quantification.

Label-free detection of protein binding with multisine SPR microchips.

Label-free techniques such as surface plasmon resonance (SPR) have used a step-response excitation method to characterize the binding of two biochemical entities. A major drawback of the step response technique is its high susceptibility to thermal drifts and noise which directly determine the minimum detectable binding mass. In this paper we present a new frequency-domain method based on the use of multisine chemical excitation that is much less sensitive to these disturbances. The multisine method was implemented in a PDMS microfluidic chip using a dual channel, dual multiplug chemical signal generator connected to functionalized and reference SPR binding spots. Kinetic constants for the reaction are extracted from the characteristics of the sense spot response versus frequency. The feasibility of the technique was tested using a model system of Carbonic Anhydrase-II analyte and amino-benzenesulfonamide ligand. The experimental signal to noise ratio (SNR) for the multisine measurement is about 32 dB; 7 dB higher than that observed with the single step-response method, while the overall measurement time is twice as long as the step method.

Low noise detection of biomolecular interactions with signal-locking surface plasmon resonance.

Surface plasmon resonance (SPR) is a popular technique for label-free detection of biomolecular interactions at a surface. SPR yields quantitative kinetic association and dissociation constants of surface interactions such as the binding of two molecular species, one present in the liquid phase and the other immobilized at the surface. Current state-of-the-art SPR systems extract kinetic constants from measurements of the step response of the interaction versus time. The step response measurement is subject to the influence of noise and drift disturbances that limit its minimum-detectable mass changes. This paper presents a new SPR technique that measures the biomolecular interaction not in time but over a very narrow frequency range under periodic excitation. The measured response is, thus, locked to a very specific narrow band signal. This narrow band spectral sensing scheme has a very high degree of rejection to uncorrelated spurious signals. The signal-locked SPR technique was implemented using a chemical modulator chip connected to a set of functionalized Au sensing sites downstream. Binding experiments for a model system of carbonic anhydrase-II (CA-II) analyte and immobilized 4-(2-aminoethyl)benzenesulfonamide (ABS) ligand display a 100-fold (20 dB) improvement in the measured signal-to-noise ratio (SNR) when using the new technique compared to the SNR achieved using the conventional step response method.