ABSTRACT
Four patients with hepatocellular carcinoma (HCC) out of a group of 132 with non-Hodgkin's lymphoma (NHL) are described. HCC was the most common second neoplasm in this series; in contrast, only 2 cases of HCC associated with NHL have been reported in the English literature. The diagnosis of HCC was suggested by ultrasound (US) and confirmed by ultrasonically guided fine-needle biopsy (UG-FNB). The 4 cases of HCC arose from cirrhosis. In this series, 10 out of 132 patients (7.6%) presented cirrhosis. Some considerations concerning the possible role of NHL (and/or the related therapy) in promoting the development of HCC in cirrhotic patients are discussed. The usefulness of US and of UG-FNB in the management of the patient with NHL is emphasized.
Subject(s)
Carcinoma, Hepatocellular/etiology , Liver Neoplasms/etiology , Lymphoma, Non-Hodgkin/complications , Neoplasms, Multiple Primary , Adolescent , Aged , Aged, 80 and over , Biopsy, Needle , Female , Hepatitis B/complications , Humans , Liver Cirrhosis/complications , Lymphoma, Non-Hodgkin/diagnosis , Male , Middle Aged , UltrasonographySubject(s)
Multiple Myeloma/diagnosis , Aged , Biopsy, Needle , Female , Humans , Lung/pathology , Male , Thorax/pathology , UltrasonographyABSTRACT
A case of intracerebral nodular leukemic involvement arising during acute nonlymphocytic leukemia (ANLL)-M3 in complete remission is reported. Cerebrospinal fluid examination was normal. Computed tomography (CT) of the brain was consistent with nodular leukemic deposits. Cranial irradiation and intrathecal chemotherapy induced a complete resolution of the lesions. Twenty cases of nodular intracerebral leukemic involvement in ANLL are reviewed. About half of the patients with central nervous system (CNS) leukemia, when submitted systematically to neuroradiological investigations, presented intracerebral solid deposits. The value of CT scan is emphasized.
