ABSTRACT
OBJECTIVE: We evaluated neuropsychological tests to compare cognitive impairment between two types of multiple system atrophy: predominant parkinsonism (MSA-P) and predominant cerebellar ataxia (MSA-C). PATIENTS AND METHODS: This cross-sectional study included 14 patients diagnosed with MSA: four with MSA-C and ten with MSA-P. Presence of motor symptoms was determined by using the Unified Rating MSA Scale (URMSAS). Non-motor symptoms were evaluated by the Short Form Health Survey (SF-36), Scales for Outcomes in Parkinson's disease Autonomic (SCOPA-AUT), Hospital Anxiety and Depression Scale (HADS), and Beck Depression Inventory (BDI). Neuropsychological tests were used to evaluate general cognition, verbal and visual memory, working memory, constructional ability, visuospatial, language, and executive function. RESULTS: The median age of the patients was 62 years, median disease duration was 3.5 years, and median education level was 10 years. The median Mini-Mental State Examination (MMSE) score was 26.5 points, and median Mattis Dementia Rating Scale (MDRS) score was 131.5. We compared the continuous data between the two MSA subtypes and observed that bodily pain reported in the quality of life questionnaire, SF-36, was worse in MSA-P (p<0.05), and attention function evaluated by MDRS was significantly lower in MSA-C than MSA-P (p<0.05). CONCLUSION: Our comparative study of cognitive impairment in MSA-P and MSA-C showed that both groups had impaired executive and visuospatial functions, while the attention deficit was predominant only in MSA-C. These findings support the concept that cognitive deficit originates from striatofrontal dysfunction and cerebellar degeneration. Our study also suggests that cognitive impairment is relevant in MSA, and clinical neurologists should not neglect evaluation of these aspects in their daily clinical practice.
Subject(s)
Cognitive Dysfunction/diagnosis , Cognitive Dysfunction/psychology , Multiple System Atrophy/diagnosis , Multiple System Atrophy/psychology , Neuropsychological Tests , Aged , Aged, 80 and over , Cognitive Dysfunction/complications , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Multiple System Atrophy/complicationsABSTRACT
Para caracterizar as alteraçöes articulatórias de crianças na faixa etária de seis a oito anos, 129 alunos de uma escola estadual de Säo Paulo foram submetidos à uma triagem fonoaudiológica que constava da emissäo de 25 palavras através da estimulaçäo com figuras. Após levantamento das alteraçöes encontradas, foram consideradas para discussäo apenas aquelas que obtiveram o índice de ocorrência acima de dez por cento do total de crianças e foram levantadas hipóteses explicativas de interferência de aspectos plásticos e dinâmicos da língua, associados às influências que o meio ambiente exerce sobre cada indivíduo, do que propriamente dito, a uma inabilidade própria do falante
