1.
J Clin Endocrinol Metab
; 40(5): 892-5, 1975 May.
Article
in English
| MEDLINE
| ID: mdl-1092712
ABSTRACT
The effect of intravenous synthetic luteinizing hormone releasing hormone (LH-RH) on plasma radioimmunoassayable levels of gonadotropins was investigated in 6 women suffering from Cushing's disease with bilateral adrenal hyperplasia. In five of six cases no significant variation of plasma LH levels was found following stimulation; in one case the response to LH-RH was present although slightly reduced below the normal range. By contrast in all cases the plasma FSH response was similar to that recorded in normal subjects. The explanation of impaired LH response is not clear but the possibility that endogenous hypercortisolism affects the pituitary responsiveness to LH-RH has to be considered.
Subject(s)
Cushing Syndrome/blood , Gonadotropin-Releasing Hormone/pharmacology , Luteinizing Hormone/blood , 17-Hydroxycorticosteroids/urine , 17-Ketosteroids/urine , Adult , Aged , Amenorrhea/blood , Amenorrhea/complications , Cushing Syndrome/complications , Cushing Syndrome/drug therapy , Estradiol/blood , Female , Follicle Stimulating Hormone/blood , Gonadotropin-Releasing Hormone/therapeutic use , Humans , Hydrocortisone/blood , Middle Aged , Pituitary Gland/drug effects , Pituitary Gland/physiopathology , Progesterone/blood , Testosterone/blood , Time Factors
2.
Boll Soc Ital Biol Sper
; 44(18): 1490-4, 1968 Sep 30.
Article
in Italian
| MEDLINE
| ID: mdl-5732920