Evaluation of lung pathology in Dirofilaria immitis-experimentally infected dogs treated with doxycycline or a combination of doxycycline and ivermectin before administration of melarsomine dihydrochloride.

Adulticide therapy in heartworm (Dirofilaria immitis)-infected dogs can lead to thromboembolism, which can seriously compromise post-treatment health status. Lung pathology following adulticide therapy was evaluated in three groups of experimentally infected dogs. Group 1 was treated with doxycycline at 20 mg/kg per os once daily for 30 days post infection followed by an intramuscular injection of melarsomine dihydrochloride (2.5 mg/kg) at Week 12, followed 1 month later by two injections 24 h apart. Group 2 was treated as described for Group 1, with the addition of ivermectin at 6 mcg/kg given monthly per os for 24 weeks post-infection. Group 3 received melarsomine alone, as described above. All dogs were necropsied at Week 24 and lung pathology was evaluated. Lesion criteria included perivascular inflammation and endothelial proliferation. Lesions were scored by two independent pathologists who were blinded as to treatment. Results indicate that doxycycline treatment alone or combined with ivermectin had lower lesion scores than lungs from dogs who had received melarsomine alone. Dogs that received the combined doxycycline/ivermectin protocol and treated with adulticide showed less severe arterial lesions and the virtual absence of thrombi.

[Electric stimulation of the heart : treatment indications and criteria for choosing of pacemakers. Contribution of the Ospedale Santa Croce in Cuneo]. / L'elettrostimolazione cardiaca: indicazioni al trattamento e criteri di scelta dei pace-makers. Contributo dell'Ospedale Santa Croce di Cuneo

The various types of emergency electrical heart stimulation for the short and medium terms or permanent, are reviewed along with choice criteria. The personal series represting 5 years experience at the Cuneo S. Croce Hospital is reported.

[Ventilation and continued positive-pressure respiration in resuscitation]. / La ventilazione a pressione positiva continua in rianimazione

Expiratory positive pressured used as a routine procedure in patients with healthy lungs and those with serious pulmonary alterations since 1973 is described. It has been found that CPPV offers effective opposition to the gradual desaturation of arterial blood in O2 encountered with IPPV.