[Effects of glucocorticoids on the gastrointestinal tract of normal rats and rats deficient in endogenous prostaglandins]. / Effetti dei glicocorticoidi sull'apparato gastro-enterico di ratti normali e di ratti carenti in prostaglandine endogene.

Here are studied the effects of administration of prednisolone on intestinal tract of normal rats and of rats into which a lack of prostaglandins has been caused and shown. The appearance of ulcerative lesions of the same type and of the same size in both groups of the studied animals might lead us to believe that the ulcerative action of glucocorticoids, at least in some cases, may be independent from the production of prostaglandins and may thus be attributed to other mechanisms.

[Effects of indomethacin on rats kept on a normal diet and on a diet without prostaglandin precursors]. / Effetti dell'indometacina in ratti a dieta normale e a dieta carente in precursori delle prostaglandine.

The effects of diet lack of precursors of prostaglandins on the rat's gastrointestinal tract are described. Afterwards the different seriousness of the ulcerative lesions caused by indomethacin on normal rats and on rats kept on a diet lack of precursors of prostaglandins is weighed. The achieved experiment permits to confirm the cytoprotective effect of prostaglandins on the gastrointestinal tract and to suppose this effect should take place above all in reply to ulcerogenic exogenous stimulants.