1.
J Pharm Sci
; 64(11): 1855-8, 1975 Nov.
Article
in English
| MEDLINE
| ID: mdl-811786
ABSTRACT
Glutamic acid analogs containing 3- and 4-methyl and 2-, 3-, and 4-phenyl substituents were prepared. The 3- and 4-methyl- and 3- and 4-phenylglutamic acids did not inhibit Plasmodium berghei and were nontoxic to the host (mice) at 640 mg/kg. The five analogs in addition to 2-methlglutamic acid were inactive against Lactobacillus casei at 1000 mug/ml in a defined medium: against Escherichia coli, only 2-methylglutamic acid caused 27% inhibition at 10,000 mug/ml. All six analogs failed to inhibit Aspergillus niger, Aspergillus oryzae, Trichoderma viride, and Myrothecium verrucaria in a defined medium below 10,000 mug/ml.
Subject(s)
Glutamates/chemical synthesis , Animals , Antimalarials/chemical synthesis , Antimalarials/therapeutic use , Escherichia coli/drug effects , Glutamates/pharmacology , Glutamates/therapeutic use , Lacticaseibacillus casei/metabolism , Malaria/drug therapy , Mice , Microbial Sensitivity Tests , Mitosporic Fungi/drug effects , Plasmodium berghei , Spectrophotometry, Infrared
2.
Biochemistry
; 11(10): 1953-8, 1972 May 09.
Article
in English
| MEDLINE
| ID: mdl-4112621