ABSTRACT
OBJECTIVES: To determine whether transtympanic steroid administration may be an effective treatment for sudden onset sensorineural hearing loss (SSNHL) in patients for whom systemic steroid treatment has failed or who were not candidates for systemic steroids. METHODS: The standard medical regimen for SSNHL usually involves systemic steroid therapy. Unfortunately, some patients do not respond successfully to or are poorly tolerant of systemic steroids. Transtympanic administration of steroids has been suggested as an alternative to systemic therapy. A prospective study was designed to evaluate the hearing outcomes in SSNHL patients treated with transtympanic steroids. Patients received transtympanic steroids if oral steroids had failed to work or if they were not able to tolerate oral steroids. Transtympanic steroids were administered through a ventilation tube placed with the patient under local anesthesia. Steroid administration was performed on 4 separate occasions over the course of 10 to 14 days. Hearing was assessed immediately before therapy and within 1 to 2 weeks after therapy. RESULTS: Hearing improvement was documented in 10 of 23 patients (44%) who underwent transtympanic steroid administration. This represents a 44% hearing salvage in patients for whom steroid treatment would otherwise have been considered a failure. CONCLUSION: Transtympanic steroid therapy may be an alternative treatment for patients with SSNHL for whom systemic steroid therapy had failed or who could not tolerate systemic steroid therapy.
Subject(s)
Dexamethasone/administration & dosage , Glucocorticoids/administration & dosage , Hearing Loss, Sensorineural/drug therapy , Methylprednisolone/administration & dosage , Adult , Aged , Aged, 80 and over , Audiometry, Pure-Tone , Female , Humans , Instillation, Drug , Male , Middle Aged , Prospective Studies , Tympanic MembraneABSTRACT
HYPOTHESIS: The authors believe that anatomic differences render the superior division of the vestibular nerve more susceptible to injury during vestibular neuritis. The purpose of the study was to investigate anatomic differences between the superior vestibular nerve and singular nerve canals. BACKGROUND: Previous studies of temporal bones have revealed vestibular nerve degeneration in patients with vestibular neuritis. Although the cause of this degeneration has not been established, it has been noted that the superior division of the vestibular nerve is preferentially affected, with sparing of the inferior division. The superior vestibular nerve and the singular nerve, a branch of the inferior vestibular nerve, both pass through canals interlaced with bony networks before reaching the peripheral receptors. METHODS: The authors performed histologic analysis of 40 normal temporal bones randomly selected from their temporal bone library. With a micrometer, measurements were taken of the individual canals. The ratio of the total bony spicule component to the total canal width was obtained for both the superior vestibular nerve and the singular nerve. The length of the canals was also measured. Arteriole:arteriolar canal ratios of the superior vestibular nerve and singular nerve were obtained. RESULTS: The bony channel of the singular nerve had an average length of 0.59 mm, and the average length of the superior vestibular nerve was 2.30 mm (p < 0.001). The ratio of total bony spicule width to total canal width was significantly smaller (p < 0.05) for the singular nerve (0.30 mm) compared with the superior vestibular nerve (0.34 mm). The arteriole: arteriolar canal ratio was significantly smaller (p < 0.05) for the singular nerve (0.45 mm) than for the superior vestibular nerve (0.54 mm). CONCLUSION: The bony canal of the superior vestibular nerve is longer than the singular nerve canal. Additionally, the superior vestibular nerve and arteriole travel through a relatively narrower passage than the singular nerve and its vascular supply. From an anatomic standpoint, this renders the superior division of the vestibular nerve more susceptible to entrapment and possible ischemic labyrinthine changes.
Subject(s)
Vestibular Nerve/pathology , Vestibular Neuronitis/diagnosis , Humans , Nerve Degeneration/pathology , Temporal Bone/pathologyABSTRACT
OBJECTIVE: To characterize the appearance of the normal vestibular aqueduct on coronal computed tomography (CT). DESIGN: Retrospective evaluation of routine CT images of the temporal bones. SETTING: Private tertiary care center. PATIENTS: Twenty-four children and young adults (14 females and 10 males), aged 2 to 24 years (average age, 10 years). MAIN OUTCOMES MEASURES: Axial CT images were evaluated for the size of the vestibular aqueduct as previously described. On coronal CT images the vestibular aqueduct was evaluated for shape, dimensions, and angle. These measurements were made posteriorly, at the first point of vestibular aqueduct definition, and anteriorly, where the vestibular aqueduct abuts the posterior semicircular canal. RESULTS: We were able to measure the vestibular aqueduct on 100% of the anterior coronal views, 77% of the midisthmus axial CT images, and 53% of posterior coronal CT images, (P<.001). The shape of the vestibular aqueduct on coronal CT scans varied posteriorly to anteriorly from being a slit to being an oval or round. The dimensions (mean + SD) of the isthmus on the anterior coronal views were 3.1 + 1.8 mm long by 1.6 + 0.8 mm wide. The upper limits of normal, as defined by the mean + 2 SDs, are 6.8 x 3.3 mm. CONCLUSIONS: We have easily and consistently identified the vestibular aqueduct on coronal CT images; in fact, we found the vestibular aqueducts more consistently measurable on coronal CT scans than on axial CT scans. The addition of these views may improve the sensitivity of the CT scan in the evaluation of sensorineural hearing loss in children.
Subject(s)
Tomography, X-Ray Computed/methods , Vestibular Aqueduct/diagnostic imaging , Adolescent , Adult , Child , Child, Preschool , Female , Humans , MaleABSTRACT
Meniere's disease is an idiopathic disorder of the inner ear characterized by the syndrome of endolymphatic hydrops, episodic vertigo, fluctuating hearing loss, tinnitus, and aural fullness. People with this disorder may be severely disabled. Medical therapy exists in the form of diuretics and dietary restriction of salt to minimize the fluid pressure in the labyrinth and cochlea. Treatment of allergies with desensitization and steroids has also shown to be effective in selected patients. Surgical therapies exist in two categories, conservative and ablative. Endolymphatic sac decompression with or without shunt placement remains highly effective and we feel that it should be the first line surgical therapy for patients who fail medical therapy. Ablative therapies include labyrinthectomy (medical or surgical) and vestibular neurectomy. Both of these procedures control the episodic vertigo by destroying vestibular function in the affected ear and should be reserved for patients who have persistent vertigo in spite of more conservative treatments.
Subject(s)
Meniere Disease , Disease Progression , Ear, Inner/surgery , Humans , Meniere Disease/diagnosis , Meniere Disease/physiopathology , Meniere Disease/therapyABSTRACT
Meningiomas are slow-growing lesions that represent approximately 20% of all intracranial tumors and are the second most common tumor of the cerebellopontine angle. In contrast, primary extracranial meningiomas are found relatively infrequently, and most cases have inadequate radiologic studies to determine if they were actually an extension from a primary intracranial source. Meningiomas of the intratemporal segment of the facial nerve have also been reported, but they are exceedingly rare and their pathophysiology remains unclear. We report a case of a meningioma of the facial nerve in the fallopian canal of a 7-year-old girl and review pertinent literature.
Subject(s)
Cranial Nerve Neoplasms/diagnosis , Facial Nerve Diseases/diagnosis , Meningioma/diagnosis , Temporal Bone/innervation , Child , Cranial Nerve Neoplasms/surgery , Facial Nerve/surgery , Facial Nerve Diseases/surgery , Facial Paralysis/diagnosis , Female , Follow-Up Studies , Hearing Loss, Sensorineural/etiology , Humans , Meningioma/surgery , Postoperative Complications , Sural Nerve/transplantationABSTRACT
OBJECTIVES: The current gold standard for diagnosis of benign paroxysmal positional vertigo (BPPV) is the Dix-Hallpike maneuver. However, because of fatigability, the Dix-Hallpike is often falsely normal. The objective of this study was to evaluate the utility of vestibular autorotation testing in the diagnosis of BPPV. METHODS: The charts of 210 patients at a tertiary referral center for vertiginous disorders were reviewed. All patients underwent clinical evaluation, Dix-Hallpike testing, audiometry, electronystagmography, and vestibular autorotation testing. The vestibular autorotation results of patients with BPPV were compared with the findings in patients with non-BPPV vestibular disorders. The sensitivity and specificity of vestibular autorotation testing in diagnosing BPPV were calculated. RESULTS: Ninety-one patients (42.9%) had BPPV, 76 patients (36.2%) had vertigo of uncertain cause, 28 (13.3%) had unilateral vestibular hypofunction, 9 patients (4.3%) had Meniere's disease, and 2 patients (1.0%) had perilymphatic fistula. Patients with BPPV were 3.32 times more likely to have a normal horizontal gain (95% CI = 1.54-7.19). A normal horizontal gain is 85% sensitive but only 36% specific for BPPV. Patients with BPPV were 1.9 times more likely to have vertical phase lead (95% CI = 0.95-3.93). Patients with BPPV were 2.20 times more likely to have both normal horizontal gain and vertical phase lead (95% CI = 1.03-4.69) The sensitivity of the combination of normal horizontal gain and vertical phase lead on vestibular autorotation testing is 87% specific but only 25% sensitive in the diagnosis of BPPV. CONCLUSION: A normal horizontal gain or vertical phase lead on vestibular autorotation testing in a vertiginous patient is suggestive of but not exclusive to a diagnosis of BPPV. The combination of a normal horizontal gain and vertical phase lead on vestibular autorotation testing is highly suggestive of the diagnosis of BPPV. Adjuvant use of these parameters in vestibular autorotation testing may prove to be helpful in the diagnosis of BPPV.
Subject(s)
Vertigo/etiology , Vestibular Function Tests , Electrooculography , Female , Fistula/complications , Fistula/diagnosis , Humans , Labyrinth Diseases/complications , Labyrinth Diseases/diagnosis , Male , Meniere Disease/complications , Meniere Disease/diagnosis , Middle Aged , Rotation , Sensitivity and Specificity , Vertigo/diagnosis , Vestibular Diseases/complications , Vestibular Diseases/diagnosisABSTRACT
OBJECTIVE: To determine the feasibility of perioperative erythropoietin to avoid blood transfusion in head and neck cancer surgery. STUDY DESIGN: Retrospective chart review. METHODS: Ninety-nine patients undergoing surgical resection of head and neck tumors at our institution were assessed for demographic data, nutritional parameters, tumor/surgical information, hematological/transfusion data, and contraindications to erythropoietin. Each transfusion was classified as to its appropriateness, and the potential benefit of erythropoietin was assessed in each patient. A cost analysis was also performed. RESULTS: Most transfused patients (63%) received too many units. A subgroup at high risk of transfusion was identified who would benefit most from perioperative erythropoietin. Assuming that perioperative erythropoietin therapy is equivalent to the transfusion of 4 units, we estimate that the majority (741%) of transfused patients would not have required a transfusion if more stringent transfusion criteria were followed and those at high risk were given perioperative erythropoietin. Although the cost for transfusing 4 units is equivalent to that of a perioperative course of erythropoietin, the overall direct cost of erythropoietin treatment would actually have been more expensive. CONCLUSIONS: Perioperative erythropoietin therapy may be appropriate for a subgroup of head and neck cancer patients, but a prospective randomized controlled study in such a subgroup is needed to better define those most likely to benefit from it and to assess actual cost/benefit ratios.
Subject(s)
Blood Transfusion , Erythropoietin/therapeutic use , Head and Neck Neoplasms/surgery , Preoperative Care , Adult , Blood Transfusion/economics , Blood Transfusion/statistics & numerical data , Chi-Square Distribution , Contraindications , Costs and Cost Analysis/economics , Costs and Cost Analysis/statistics & numerical data , Erythropoietin/economics , Feasibility Studies , Female , Head and Neck Neoplasms/blood , Head and Neck Neoplasms/economics , Head and Neck Neoplasms/pathology , Humans , Logistic Models , Male , Neoplasm Staging , Preoperative Care/economics , Preoperative Care/statistics & numerical data , Retrospective Studies , Risk FactorsABSTRACT
OBJECTIVES: To determine the incidence of nonorganic sway patterns on computerized dynamic posturography (CDP) among patients with potential secondary gain compared with patients without any obvious secondary gain. METHODS: A retrospective chart review of 100 patients who underwent clinical evaluation, audiometry, electronystagmography, and CDP was undertaken. Group 1 consisted of 50 patients who were randomly selected from a group who had pending lawsuits, worker's compensation claims, or disability claims. Group 2 consisted of 50 randomly selected patients who had no pending legal status, worker's compensation claims, or disability claims. Previously published criteria for nonorganic sway patterns were then applied to each group. Statistical analysis was performed. RESULTS: The average age of group 1 patients was 43.8 years compared with 63.2 years for group 2 patients (P < 0.0001). Among group 1 patients 50% had normal audiovestibular evaluations compared with only 4% of group 2 patients (P < 0.0001). Nonorganic sway patterns were found in 76% of group 1 patients, but only in 8% of group 2 patients (P < 0.0001). CONCLUSION: Patients who have the potential for secondary gain are generally younger and have a much higher prevalence of normal audiovestibular evaluations and a much higher prevalence of nonorganic sway patterns on CDP. A high degree of clinical suspicion should be maintained when evaluating the dizzy patient who has a pending lawsuit, worker's compensation claim, or disability claim.
Subject(s)
Dizziness/diagnosis , Malingering/diagnosis , Posture , Vestibular Function Tests , Adult , Audiometry , Diagnosis, Differential , Electronystagmography , Female , Humans , Liability, Legal , Male , Middle Aged , Postural Balance , Retrospective Studies , Signal Processing, Computer-Assisted , Workers' CompensationABSTRACT
Controversy regarding the use of anticoagulants, the evacuation of the sinus, or the use of medical treatment alone surrounds the treatment of lateral sinus thrombosis. Treatment of an epidural abscess associated with coalescent mastoiditis is much less controversial-drainage is usually recommended. The differing treatments of these complications mandate accurate diagnosis. The advent of more sophisticated radiological studies has facilitated diagnosis of these complications; however, tests are not infallible. We present three cases in which preoperative imaging demonstrates an epidural abscess mimicking lateral sinus thrombosis by compression of the vessel. A false-positive computed tomography (CT) or magnetic resonance imaging (MRI) study may lead to the wrong diagnosis and, consequently, improper treatment. In light of this possibility, we recommend surgical exploration in all such cases.
ABSTRACT
There are many known causes of vertigo, but many cases remain unexplained. Sound-induced, pressure-induced, or positional vertigo caused by bony dehiscence of the superior semicircular canal into the middle cranial fossa is a newly described etiology of vertigo. Three case studies of patients with CT evidence and surgical confirmation of bony dehiscence of the superior semicircular canal with variable presentations are described. The history, symptoms, CT findings, vestibular studies, and method of surgical repair are presented. Two patients had disabling vertigo and one had no vestibular symptoms. All underwent exploration via a middle cranial fossa approach with repair of the dehiscence. The bony dehiscence of the superior semicircular canal of the asymptomatic patient was identified and closed at the time of an encephalocele repair procedure. All patients did well postoperatively and both patients with vertigo improved. Bony dehiscence of the superior semicircular canal may cause vertigo or be asymptomatic and should be added to the differential diagnosis of vertigo.
Subject(s)
Semicircular Canals , Vertigo/etiology , Bone Cements , Bone Transplantation , Diagnosis, Differential , Electronystagmography , Female , Follow-Up Studies , Humans , Intracranial Pressure , Male , Meniere Disease/diagnosis , Middle Aged , Semicircular Canals/diagnostic imaging , Semicircular Canals/surgery , Temporal Bone/diagnostic imaging , Time Factors , Tomography, X-Ray Computed , Vertigo/diagnosisSubject(s)
Ethics, Medical , Hearing Aids , Patient Selection , Stapes Surgery , Humans , Judgment , Logic , Stapes Surgery/adverse effectsABSTRACT
The efficacy of hyaluronic acid (HA) foam in the prevention of middle ear adhesions and other structural abnormalities in guinea pigs undergoing experimental tympanoplasty was investigated. Postoperative changes in the middle ear were evaluated by light microscopy after 6 weeks. The presence of adhesions, diminution of airspace, new bone formation, tympanic membrane (TM) formation, and mucosal inflammation was characterized by an objective grading system. Results were compared to absorbable gelatin sponge (AGS) and a control group (no middle ear packing). The control group showed the best average scores for all parameters tested except for adhesion formation. However, these results were statistically significant only when compared with those of the AGS group for airspace preservation, new bone formation, and TM formation. Although the HA foam group showed better average results than did the AGS group for all parameters tested, none were statistically significant. Although HA foam appears to be a promising middle ear packing agent, further experimental trials are warranted before any firm conclusions may be made.
Subject(s)
Adjuvants, Immunologic/pharmacology , Ear, Middle/drug effects , Hyaluronic Acid/pharmacology , Tympanoplasty , Animals , Ear, Middle/abnormalities , Ear, Middle/pathology , Guinea Pigs , Mucous Membrane/drug effectsABSTRACT
OBJECTIVE: Auditory testing is not routinely performed within 4-6 weeks after stapedotomy, because hearing acuity is thought to be transiently depressed. In rare circumstances, postsurgical auditory and vestibular complaints may lead one to test hearing soon after stapedotomy. The early postoperative effects of carbon dioxide (CO2) and potassium titanyl phosphate (KTP) lasers, which now are routinely used to perform stapedotomies, have not been reported. The purpose of this report is to present normative data for auditory thresholds measured within 2 weeks of laser stapedotomy. STUDY DESIGN: The study design was a prospective, unblinded study. SETTING: The study was conducted at three academic medical centers. PATIENTS: Thirty-six subjects undergoing 38 stapedotomies for otosclerosis by 5 surgeons participated. MAIN OUTCOME MEASURES: Behavioral audiometry was performed using standard techniques beginning before surgery and continuing through > 1 year after surgery. RESULTS: The CO2 laser was used in 26 stapedotomies and the KTP laser was used in 12. Nine cases were revision procedures. Bone conduction pure-tone averages and speech discrimination scores did not worsen during the early postoperative period. Bone conduction at 250 and 4,000 Hz dropped slightly within the first 2 weeks (-4.3 and -6.7 dB) but recovered thereafter. Bone conduction at 1,000 Hz actually improved within the first week after surgery (+6.2 dB, p = 0.021). Significant improvements in air conduction thresholds (and air-bone gap) were seen at the second week and late audiometry. The results for CO2 and KTP laser-treated groups were not significantly different. CONCLUSIONS: Cochlear function is not significantly depressed in the early postoperative period after laser (CO2 or KTP) stapedotomy.
Subject(s)
Auditory Threshold , Laser Therapy , Stapes Surgery , Audiometry, Pure-Tone , Bone Conduction , Hearing Loss, Sensorineural/diagnosis , Humans , Middle Aged , Otosclerosis/surgery , Prospective Studies , Speech Discrimination Tests , Time Factors , Treatment OutcomeABSTRACT
Surgical intervention has been offered to patients with Meniere's disease who have failed medical treatment and have disabling symptoms. Surgical options have included labyrinthectomy (mechanical and chemical), vestibular neurectomy, and endolymphatic sac surgery with or without shunting. We present a modification of endolymphatic sac decompression surgery that includes wide decompression of the sigmoid sinus, posterior cranial fossa dura, and endolymphatic sac (sac-vein decompression). Thirty-five patients underwent 37 primary procedures with 2 years of follow-up. Patients were evaluated according to the 1985 American Academy of Otolaryngology-Head and Neck Surgery criteria for assessing Meniere's disease. Vestibular symptom severity was resolved or mild in 92% and disability severity was none or mild in 95% of patients at 2 years after surgery. Vertigo control was complete or substantial in 85% and 100% of patients at 1 and 2 years after surgery. Audiologic data showed stable or improved hearing in 86% and 85% of patients at 1 and 2 years after surgery. In summary, wide decompression of the sigmoid sinus, posterior cranial fossa dura, and endolymphatic sac offers improved control of vertigo and hearing stabilization for intractable Meniere's disease compared with simple endolymphatic sac decompression or shunt surgery.
Subject(s)
Dura Mater/surgery , Endolymphatic Sac/surgery , Meniere Disease/surgery , Adult , Aged , Aged, 80 and over , Cranial Fossa, Posterior/surgery , Humans , Meniere Disease/classification , Middle Aged , Patient Satisfaction , Prospective Studies , Severity of Illness Index , Treatment OutcomeABSTRACT
Congenital aural atresia is viewed by many physicians as a poorly characterized, arcane, clinical entity associated with a variety of hearing deficits. In fact, congenital aural atresia represents a disease spectrum predicated on the reliable embryological development of the first and second branchial apparatus. All degrees of microtia, canal atresia, and middle ear structure malformation are identified by this disease process. Many classification schemata have been proffered since the turn of the century to assist the otologist with a better means of assessing the patient's suitability as a surgical candidate. Clinical, audiological, and radiographic evaluation of congenital aural atresia is essential in selecting the appropriate candidates for surgery or hearing amplification. The high resolution CT scan has advanced the understanding and preoperative assessment of this condition. Surgical repair of the external ear and middle ear malformations is effective in properly selected patients. Essential background information, relevant embryology, patient evaluation, treatment, and current controversies related to congenital aural atresia are discussed.
Subject(s)
Ear/abnormalities , Child, Preschool , Ear/embryology , Ear/surgery , Ear, External/abnormalities , Ear, Inner/abnormalities , Hearing Loss, Conductive/etiology , Humans , Infant , Treatment OutcomeABSTRACT
HYPOTHESIS: We have theorized that surgical occlusion of all three semicircular canals (TCO) may be an effective means to treat vestibular pathology limited to semicircular canal dysfunction while preserving hearing and otolithic function. BACKGROUND: A procedure that would eliminate vertigo while preserving hearing and minimizing postoperative dysequilibrium would be desirable. METHODS: Staged bilateral TCO was performed on four cats and compared to staged bilateral labyrinthectomy in four cats. Balance and gait analysis were performed for 3 weeks after each surgical procedure--a total of 6 weeks of testing. RESULTS: Balance testing, gait analysis, and righting reflex were found to be better among the cats undergoing TCO compared to labyrinthectomy. CONCLUSIONS: Compared to labyrinthectomy in the cat, TCO appears to have advantages for vestibular compensation after unilateral and contralateral surgery.
Subject(s)
Ear, Inner/surgery , Semicircular Canals/surgery , Animals , Cats , Ear, Inner/physiopathology , Male , Postoperative Complications , Semicircular Canals/physiopathology , Vertigo/physiopathology , Vertigo/surgeryABSTRACT
The eustachian tube has several functions that are important in maintaining the normal state of the middle ear. The ability of the eustachian tube to carry out these functions changes with age. Certain pathophysiologic mechanisms may affect the normal state of the eustachian tube and predispose people, especially children, to otitis media.
Subject(s)
Eustachian Tube/physiopathology , Aging/physiology , Child , Disease Susceptibility , Eustachian Tube/anatomy & histology , Eustachian Tube/physiology , Humans , Otitis MediaABSTRACT
Bell's palsy or idiopathic palsy is the most common disorder affecting the facial nerve. Diagnosis is primarily one of exclusion. There is typically an acute unilateral facial paresis that evolves in 24 to 48 hours. Etiology and pathophysiology are heavily disputed, and as of yet unknown. The natural history of Bell's palsy is favorable. Eight-four percent show satisfactory recovery without any treatment, however 16% suffer moderate to severe sequelae. Prognosis is influenced by degree of paresis, age of patient, and time until first signs of recovery. Prognostic testing currently involves various electrophysiological tests. More than 90% degeneration of the facial nerve carries a poor prognosis for recovery; these are the patients who may benefit from facial nerve decompression surgery. If surgery is performed it should be done early (< 21 days from onset of palsy) and should include a middle cranial fossa decompression. Steroids are generally agreed to be beneficial. Acyclovir would seem to be a promising drug; however studies have not adequately assessed its use.
Subject(s)
Facial Paralysis/therapy , Acyclovir/therapeutic use , Decompression, Surgical , Diagnosis, Differential , Facial Nerve/physiopathology , Facial Paralysis/etiology , Facial Paralysis/physiopathology , Humans , Neurologic Examination , Prognosis , Steroids/therapeutic useABSTRACT
Delayed facial palsy after acoustic neuroma resection may occur in up to 15% of cases. Prognosis is generally good if the palsy does not progress to total paralysis. However, a delayed palsy with subsequent total paralysis has a more variable final outcome, which ranges from normal function to permanent total paralysis. This delayed paralysis has been attributed to edema from surgical manipulation of the facial nerve. Steroids and intraoperative decompression of the meatal foramen have been used with some success, but some cases remain refractory to these measures. Herpes simplex virus and varicella-zoster virus are ubiquitous in the population and remain in a latent state in neural ganglia. These viruses are reactivated during times of stress. Trigeminal nerve surgery (partial sensory rhizotomy and microvascular decompression) stimulates reactivation of herpes simplex with manifestations in the sensory distribution of the trigeminal nerve in 38-94% of procedures. Prevention of this reactivation has been demonstrated in placebo-controlled trials by using prophylactic acyclovir. We present a patient who underwent translabyrinthine resection of an intracanalicular acoustic neuroma and in whom developed otalgia, vesicles on the ear canal and the ipsilateral buccal mucosa, and progressive facial palsy the week after surgery. Serologic evaluation confirmed the diagnosis of herpes zoster oticus. Reactivation of latent virus apparently occurred as a result of surgical manipulation of the facial nerve. This parallels viral reactivation seen in trigeminal nerve surgery. We propose a new theory for an additional cause of delayed facial palsy after acoustic neuroma resection-reactivation of latent herpesvirus resulting from surgical trauma. Acyclovir should be evaluated in clinical trials for a prophylactic role in patients undergoing acoustic neuroma resection or a therapeutic role in patients in whom a delayed postoperative facial palsy develops.