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Nat Prod Res ; 35(3): 455-464, 2021 Feb.
Article in English | MEDLINE | ID: mdl-31282749

ABSTRACT

The n-hexane extract of Knema pachycarpa fruits (Myristicaceae family), exhibiting strong anti-acetylcholinesterase activity, was investigated by gas chromatography/mass spectrometry and then purified by column chromatography. Guided by GC/MS profiling and bioassay, chromatographic separations led to the isolation of five new compounds: two anacardic acid derivatives 1-2, two cardanol derivatives 3-4 and a cardol derivative 5, along with mixtures of known phenolic lipids 6-9. The chemical structures were determined by various spectroscopic methods. New isolated compounds 1-5 were evaluated for their cytotoxicity and anti-acetylcholinesterase activity. Cardanol 3 and cardol 5 were the most active compounds in the acetylcholinesterase inhibitory assay with IC50 values of 2.60 ± 0.24 µM and 2.46 ± 0.23 µM, respectively. Cardanol 4 and cardol 5 showed moderate cytotoxicity against Hela and MCF-7 cancer cell lines with IC50 values ranging from 31.36 ± 0.41 µM to 41.30 ± 2.49 µM.


Subject(s)
Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/pharmacology , Cholinesterase Inhibitors/chemistry , Cholinesterase Inhibitors/pharmacology , Myristicaceae/chemistry , Anacardic Acids/chemistry , Drug Evaluation, Preclinical , Fruit/chemistry , Gas Chromatography-Mass Spectrometry , HeLa Cells , Humans , MCF-7 Cells , Molecular Structure , Phenols/chemistry , Phenols/pharmacology , Plant Extracts/chemistry , Resorcinols/chemistry , Resorcinols/pharmacology
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